Results 101 to 110 of about 4,515 (264)

Incidence of postoperative retinal detachment and bacterial endophthalmitis in the Swedish national paediatric cataract register and associated risk factors

Acta Ophthalmologica, Volume 103, Issue 5, Page 561-570, August 2025.
Abstract Purpose To investigate the incidence and risk factors of retinal detachment (RD) and bacterial endophthalmitis in a cohort of children who underwent cataract surgery before the age of eight. Methods Data was retrieved from the Swedish national paediatric cataract register.
Arzu Seyhan Karatepe Hashas, Anna Linnarsson Wiklund, Jenny Gyllén, Birgitte Haargaard, Gunilla Magnusson, Alf Nyström, Kristina Tornqvist, Eric Trocmé, Ulrika Kjellström   +8 more
wiley   +1 more source

Preference for a fixed combination of brinzolamide/timolol versus dorzolamide/ timolol among patients with open-angle glaucoma or ocular hypertension

Clinical Ophthalmology, 2013
Ana Sanseau,1 Juan Sampaolesi,2 Emilio Rintaro Suzuki Jr,3 Joao Franca Lopes,4 Hector Borel51Instituto de la Visión, Ciudad de Buenos Aires, Argentina; 2Consultorio Oftalmologico Sampaolesi, Ciudad de Buenos Aires, Argentina; 3Oftalmoclinica ...
Sanseau A, Sampaolesi J, Suzuki Jr ER, Lopes JF, Borel H   +4 more
doaj  

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
core   +1 more source

Evaluation of Antioxidant and Enzyme Inhibition Properties of Siran Propolis: Correlations With Phenolic Content Determined by LC–MS/MS

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
The ethanolic extract of Şiran propolis exhibited strong antioxidant activity and inhibited α‐glycosidase, AChE, and human carbonic anhydrase isozymes I and II. High levels of phenolic acids, especially p‐coumaric and ferulic acids, correlated with its bioactivity.
Neslihan Balci, Kubra Aslan, Adem Erturk, Ilhami Gulcin   +3 more
wiley   +1 more source

Brinzolamide ophthalmic suspension: a review of its pharmacology and use in the treatment of open angle glaucoma and ocular hypertension

Clinical Ophthalmology, 2008
Michele IesterClinica Oculistica, University of Genoa, ItalyAbstract: Brinzolamide is a white powder commercially formulated as a 1% ophthalmic suspension to reduce intraocular pressure (IOP).
Michele Iester
doaj  

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, Volume 21, Issue 29, July 24, 2025.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Gas-phase acidity of sulfonamides: implications for reactivity and prodrug design [PDF]

, 2005
A computational study at the density functional theory level was performed on bioactive and model sulfonamides with the aim of determining the factors affecting the acidity of the sulfonamido group.
Gomes, JRB, Gomes, P
core   +1 more source

Regioselective Access to Sultam Motifs through Cobalt-Catalyzed Annulation of Aryl Sulfonamides and Alkynes using an 8-Aminoquinoline Directing Group [PDF]

, 2015
The use of cobalt as catalyst in direct C[BOND]H activation protocols as a replacement for more expensive second row transition metals is currently attracting significant attention.
Ackermann, Ackermann, Ackermann, Andou, Beletskaya, Bernini, Casitas, Chen, Collins, Corbet, Daugulis, De Santis, Ding, Dong, Gensch, Godula, Grigorjeva, Grigorjeva, Grigorjeva, Guimond, He, Huestis, Hummel, Hyster, Ikemoto, Jia, Jiménez-Hopkins, Kajita, Kaneko, Larock, Lee, Li, Li, Li, Liu, Liu, Lombardino, Lyons, Ma, Majumdar, Merten, Morimoto, Mousseau, Pawar, Pham, Punji, Rakshit, Rassadin, Shah, Shi, Shilov, Shuklov, Song, Song, Stuart, Stuart, Sun, Sun, Suzuki, Tasker, Ueura, Ueura, Umeda, Wells, Wencel-Delord, Wendlandt, Wu, Wu, Wu, Wu, Wu, Yamaguchi, Yeung, Yoshino, Yu, Zhang, Zhang, Zhang, Zhao   +78 more
core   +1 more source

Synthesis of Novel Isoindolinones: Carbonic Anhydrase Inhibition Profiles, Antioxidant Potential, Antimicrobial Effect, Cytotoxicity and Anticancer Activity

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 4, April 2025.
Highly effective one‐pot synthesis of novel isoindolinones Inhibitory, antioxidant, antimicrobial cytotoxicity, and anticancer potentials of synthesized novel isoindolinone derivatives were investigated. ABSTRACT An efficient one‐pot method has been developed for synthesizing novel isoindolinone derivatives from 2‐benzoylbenzoic acid using ...
Yusuf Serdar Yazıcıoğlu, Şeydanur Elmas, Zeynep Kılıç, Murat Çelik, Buket Bakan, Ufuk Atmaca, Songül Bayrak   +6 more
wiley   +1 more source

Anticholinesterase and carbonic anhydrase inhibitory activities of natural carnosic acid derivatives: A comprehensive in vitro and in silico study

Archiv der Pharmazie, Volume 358, Issue 3, March 2025.
Carnosic acid derivatives were evaluated for their inhibitory activities against acetyl‐ and butyrylcholinesterases (AChE, BChE) and carbonic anhydrases (CAs). Rosmanol exhibited exceptional potency, surpassing tacrine and acetazolamide. Molecular docking, MM‐GBSA, and MD simulations confirmed strong binding and stability.
Zeynep Köksal, Halil Şenol
wiley   +1 more source