Results 101 to 110 of about 1,879,820 (319)

Cultural Haunting and the Trace of the Colonial Other in Arthur Conan Doyle's Short Fiction [PDF]

open access: yes, 2017
In Home Truths: Fictions of the South Asian Diaspora in Britain (2002), Susheila Nasta argues that “the arrival in Britain of several generations of black and Asian 'immigrants' in the period following decolonization and Independence was not simply the ...
Martín-González, Juan-José
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

'To every landless man, woman and child in England’: Octavia Hill and the preservation movement’ [PDF]

open access: yes, 2015
Octavia Hill is increasingly commemorated as a key figure of the heritage movement in Britain. While her contribution to preservation is usually discussed within the institutional history of the National Trust, the chapter seeks to situate Octavia Hill’s
Swenson, A
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Blowing smoke: British American Tobacco's air filtration scheme [PDF]

open access: bronze, 2006
Nadine Rae Leavell   +3 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

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