Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome. [PDF]
, 2020 BackgroundThe purpose of this study was to conduct a 20-week controlled trial of lovastatin (10 to 40 mg/day) in youth with fragile X syndrome (FXS) ages 10 to 17 years, combined with an open-label treatment of a parent-implemented language intervention (
Abbeduto, Leonard +10 more
core
Receptive–Expressive Language Phenotypes in Infants and Toddlers With Autism Features
Autism Research, EarlyView.ABSTRACT Children diagnosed with autism often present with an atypical discrepancy between their receptive and expressive language levels, or an atypical receptive–expressive language phenotype. Children with an atypical receptive–expressive phenotype present with a relative receptive language advantage (expressive level < receptive level) or a ...
Torrey Cohenour +2 more
wiley +1 more source
Is it Possible to Assess the Two-Domain Definition of the Broad Autism Phenotype Using the Available Measurement Tools? [PDF]
J Autism Dev Disord, 2022 Godoy-Giménez M +4 more
europepmc +1 more source
Adverse Childhood Experiences in Autistic and Neurotypical Girls
Autism Research, EarlyView.ABSTRACT Adverse childhood experiences (ACEs) are potentially traumatic, life‐altering events that occur in childhood with long‐term negative physical and/or mental health outcomes. Previous research, while limited and largely focused on males, suggests children with autism spectrum disorder (ASD) are at higher risk of experiencing ACEs than typically ...
Jon Ebert +4 more
wiley +1 more source
Brief Report: The Broad Autism Phenotype in Swedish Parents of Children With and Without Autism Spectrum Conditions. [PDF]
J Autism Dev Disord, 2022 Bang P +3 more
europepmc +1 more source
Autism Research, EarlyView.ABSTRACT Emotion Dysregulation (ED) refers to difficulties in using adaptive strategies to modulate and express emotional arousal in socially appropriate ways. While ED contributes to developmental trajectories including peer engagement, academic achievement, and mental health in neurotypical children, its impact on autistic children is unclear.
Yeseul Shin +5 more
wiley +1 more source
Developmental Regression in Autism Spectrum Disorders and the Broad Autism Phenotype
, 2017 This study examined the relationship between the Broad Autism Phenotype (BAP) and developmental regression in children with Autism Spectrum Disorders. A sample of 2757 children and adolescents with autism spectrum disorders was drawn from the Simons Simplex Collection, an archival database administered by the Simons Foundation Autism Research ...
openaire +1 more source
Interval Timing Is Altered in Male Nrxn1+/− Mice: A Model of Autism Spectrum Disorder
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication, and increased repetitive and stereotypical behavior. Neuroimaging shows functional abnormalities in brain areas involved in temporal processing in autistic individuals, and they also show deficits in interval timing.
Kyle M. Roddick +3 more
wiley +1 more source
Maternal Pragmatic Language Difficulties in the FMR1 Premutation and the Broad Autism Phenotype: Associations with Individual and Family Outcomes. [PDF]
J Autism Dev Disord, 2022 Klusek J, Thurman AJ, Abbeduto L.
europepmc +1 more source
The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley +1 more source