Results 71 to 80 of about 39,746 (275)

The early development of infant siblings of children with autism spectrum disorder : characteristics of sibling interactions [PDF]

, 2018
Although sibling interactions play an important role in children's early development, they are rarely studied in very young children with an older brother or sister with autism spectrum disorder (ASD). This study used a naturalistic, observational method
Bontinck, Chloè, Demurie, Ellen, Roeyers, Herbert, Van der Paelt, Sara, Warreyn, Petra   +4 more
core   +2 more sources

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness. [PDF]

, 2020
Gastrointestinal infections can be life threatening, but not much is known about the host's genetic contribution to susceptibility to gastrointestinal infections or the latter's association with psychiatric disorders.
Appadurai, Vivek, Benros, Michael E, Buil, Alfonso, Bybjerg-Grauholm, Jonas, Børglum, Anders D, Daly, Mark J, Hougaard, David M, Mors, Ole, Mortensen, Preben Bo, Nordentoft, Merete, Nudel, Ron, Schork, Andrew J, Thompson, Wesley K, Werge, Thomas   +13 more
core   +2 more sources

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

The role of single nucleotide polymorphisms within genes for oxytocin and vasopressin receptors in the presentation and severity of autistic traits

European Psychiatry, 2023
Introduction Autism spectrum disorder is a heterogeneous group of disorders that affects virtually every population, regardless of their ethnic or socioeconomic origin.
K. M. Wilczyński, A. Auguściak-Duma, A. Stasik, L. Cichoń, A. Sieroń, M. Janas-Kozik   +5 more
doaj   +1 more source

Remote Language Assessment in School‐Age Children With Phelan–McDermid Syndrome and Genotype–Phenotype Correlation

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT People with Phelan–McDermid syndrome (PMS) have reduced speech and language abilities, yet little research has profiled the communication abilities in this population. The purpose of this study was threefold: identifying the language and communication profiles of school‐aged children with PMS, identifying genetic contributions to language and ...
Sarah Quadri‐Valverde, Jessica Klusek, Linda D. Ward, Diana Ivankovic, Nancy Powers, Vijay Shankar, Rachel A. Lyman, Trudy F. C. Mackay, William Bridges, Katy Phelan, Curtis Rogers, Luigi Boccuto, Sara M. Sarasua   +12 more
wiley   +1 more source

A Subset of Autism-associated Genes Regulate the Structural Stability of Neurons

Frontiers in Cellular Neuroscience, 2016
Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect individuals’ ability to communicate and interact with others. People with ASD often exhibit marked qualitative difficulties in social interaction, communication, and ...
Yu-Chih Lin, Jeannine A Frei, Michaela B.C. Kilander, Wenjuan Shen, Gene J Blatt   +4 more
doaj   +1 more source

Family coordination in families who have a child with autism spectrum disorder [PDF]

, 2018
Little is known about the interactions of families where there is a child with autism spectrum disorder (ASD). The present study applies the Lausanne Trilogue Play (LTP) to explore both its applicability to this population as well as to assess resources ...
A Lonigro, AA Hollingshead, AB Kelly, AH Rutgers, AS Carter, C Carneiro, C Kasari, C Lord, C Lord, C Trevarthen, CD Hoffman, CG Pottie, Christian Veronesi, D Oppenheim, D Oppenheim, D Steijn van, Diane Philipp, DN Stern, E Fivaz Depeursinge, E Fivaz Depeursinge, E Fivaz Depeursinge, E Sucksmith, EM Dykens, F Laghi, Fiorenzo Laghi, G Montes, G Vivanti, GM Griffith, I Marcu, II Fishman, J Cohen, J Duvekot, J McHale, J McHale, JL Taylor, JS Karst, L Adamson, L Oberman, Laura Vismara, LC Wynne, LE Libero, LE Marsh, M Ainsworth, M Losh, M Malagoli Togliatti, MH IJzendoorn Van, N Favez, N Favez, NO Davis, NV Ekas, P Fonagy, P Fonagy, PA Rao, PJ Curran, R Giallo, R Hoefman, R Phelps, RP Hastings, S Baron-Cohen, S Minuchin, S Rogers, Silvia Mazzoni, SSF Gau, T Cadman, U Frith   +64 more
core   +1 more source

35 Individuals With HUWE1‐Related Neurodevelopmental Disorder and Suggested Clinical Evaluations

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X‐linked intellectual disability, including in the patients identified by Juberg, Marsidi, and ...
Mindy H. Li, Deziree L. Coleman, Kelsey Hogan, Danielle Luz, Lindsay Bhandari, Newell Belnap, Tiffany Busa, Charles Coutton, Klaus Dieterich, Svetlana Gorokhova, Clara Hildebrandt, Rachel Logan, Milena Mariani, Manuela Morleo, Vincenzo Nigro, John Pappas, Rachel Rabin, Kelly Schoch, Angelo Selicorni, Vandana Shashi, Rebecca Spillmann, Jennifer Sullivan, Charlotte Tardy, Samantha A. Schrier Vergano, Brock Grill, Kristin Baranano   +25 more
wiley   +1 more source

The expression and assessment of emotions and internal states in individuals with severe or profound intellectual disabilities [PDF]

, 2011
The expression of emotions and internal states by individuals with severe or profound intellectual disabilities is a comparatively under-researched area. Comprehensive or standardised methods of assessing or understanding the emotions and internal states
Adams, Dawn, Christopher, Oliver
core   +1 more source