Results 61 to 70 of about 19,233 (265)
A genome-wide scan for common alleles affecting risk for autism
, 2010 Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs).J. Miller, M. Hill, Joseph T Glessner, Pericak-Vance, M.A., Hilary Coon, Anath C Lionel, Richard Anney, Parrini, Barbara, Nadia Bolshakova, Tansey, Katherine, Melhem, Nadine, M., J. Conroy, J. Rickaby, McGrath, J., Chu, Su H., Hallmayer, Joachim, H. Hakonarson, Lamb, Janine, A., Noor, A., Katherine Sansom, Ann P Thompson, Leboyer, Marion, Magalhaes, Tiago, R., Kustanovich, Vlad, Munson, Jeff, K. Renshaw, Vincent, J.B., G. Baird, Pinto, D., Su H Chu, Gillian Hughes, C. M. Lajonchere, Hakonarson, Hakon, Folstein, Susan, E., Monaco, Anthony, P., Lynne Cochrane, Melhem, Nadine M, Schellenberg, Gerard,, Sansom, K., Regina Regan, Joseph D Buxbaum, Folstein, Susan E., Vicente, Astrid M., Abrahams, B.S., Bierut, L.J., Buxbaum, Joseph,, Paterson, Andrew D, S. Thomson, Agatino Battaglia, Ghazala K Mirza, Yaspan, Brian, L., Andrew D Paterson, Rice, John,, Jiannis Ragoussis, Soorya, L., M. L. Rutter, John I Nurnberger Jr, Wassink, Thomas, H., Klauck, Sabine M., J. Tsiantis, Marshall, Christian R., Brett S Abrahams, Klauck, Sabine M, W. Roberts, Ellen M Wijsman, B. L. Leventhal, S. E. Folstein, Guter, Stephen,, Magalhaes, Tiago,, Bailey, Anthony J, Emily L Crawford, M. A. Pericak-Vance, T. R. Magalhaes, James S Sutcliffe, Marion Leboyer, Howe, J.L., Magalhaes, Tiago R, Noakes, C., Cantor, R.M., Peter Szatmari, Helen Mcconachie, Bailey, Anthony, J., Lajonchere, Clara,, Mcmahon, William, M., Tansey, K., Cook, E.H., Migita, O., B. Thiruvahindrapduram, N. J. Minshew, R. Igliozzi, Estes, A., R. Delorme, et al., N. Sykes, Le Couteur, Ann, Holt, Richard, Salt, Jeff, Folstein, S.E., Laskawiec, Magdalena, Wijsman, E.M., G. Casallo, Munson, J., I. Drmic, Hughes, G., Cook, Edwin,, Thompson, Ann P., Poustka, Annemarie, Mantoulan, Carine, Vincent, John B., Haines, Jonathan,, Posey, David, J., B. L. Yaspan, J. P. Rice, Wijsman, Ellen, M., Drmic, I., Casey, J., Shawn Wood, Penny Farrar, Henri Mondor, Melhem, Nadine M., Wing, K., C. R. Marshall, Alison Merikangas, Wing, Kirsty, Thompson, Ann, P., Scherer, Stephen W., Andrew Crossett, Nygren, Gudrun, R. Segurado, Rutter, M.L., Gallagher, L., Rice, John P., Clara M Lajonchere, Sutcliffe, J.S., Pickles, A., M. Leboyer, S. H. Chu, V. Kustanovich, K. Wang, J. McGrath, Korvatska, Olena, Rice, John, P., Marshall, C.R., Jeff Salt, S. W. Scherer, Carson, Andrew R, Rita M Cantor, Bolton, P.F., Danielle Zurawiecki, Zurawiecki, D., N. Shah, Cook, Edwin H., Szatmari, Peter, J. T. Glessner, L. Klei, A. M. Vicente, Lund, Sabata,, C. Lord, Rutter, Michael,, L. Gallagher, G. K. Mirza, F. Duque, Guter, S.J., A. Kolevzon, Renshaw, K., Casallo, G., S. J. Guter, Rutter, Michael, L., David J Posey, M. de Jonge, Noakes, Carolyn, Alexander Kolevzon, Lund, Sabata, C., Wassink, Thomas H, Ragoussis, Jiannis, Yaspan, Brian L., Lajonchere, Clara, M., F. Volkmar, Cuccaro, Michael L, Goldberg, J., Mirza, Ghazala K., W. M. McMahon, Senman, Lili, Vieland, Veronica J, Nygren, Gudrun,, Carson, Andrew,, Liu, Xiao Qing, O. Migita, C. Kim, Lamb, J.A., Zhouzhi Wang, Lajonchere, C.M., Nancy J Minshew, Kirsty Wing, Prasad, A., Tancredi, Raffaella, T. H. Wassink, Catarina Correia, Posey, D.J., N. Bolshakova, Judith Miller, Roeder, Kathryn, C. Correia, Daniel H Geschwind, Glessner, Joseph,, Mcmahon, William,, Battaglia, A., Fernandez, Bridget A., Cantor, Rita M., Delorme, Richard, Stephen W Scherer, Pinto, Dalila, Jennifer L Howe, Goldberg, Jeremy, Gill, Michael, Jeremy R Parr, Joseph Piven, Elena Maestrini, Mcdougle, Christopher,, L. Lotspeich, Freitag, Christine M, A. Crossett, V. Hus, Wendy Roberts, Maretha De Jonge, V. J. Vieland, E. Maestrini, Margaret A Pericak-Vance, Nelson, Stanley, F., Rickaby, J., Wang, Z., V. Stoppioni, Hus, V., Mcdougle, Christopher, J., Van Engeland, H., Klei, Lambertus, Rutter, Michael L, Lund, Sabata C., Melhem, N.M., J. L. Haines, Crawford, E.L., Tsiantis, J., Abrahams, Brett,, Noor, Abdul, C. Strawbridge, Leboyer, M., R. Regan, R. Holt, Tom Berney, Thompson, Ann P, Baird, G., Glessner, Joseph T., Judith Conroy, Guter, Stephen, J., Nurnberger, John I., Geschwind, Daniel H, Pickles, Andrew, Bacchelli, E., Bolshakova, N., Christopher Gillberg, Guiomar Oliveira, Szatmari, P., Thompson, A.P., Cochrane, Lynne, S. Wood, Lajonchere, Clara M., Nurnberger, John, I., Regan, Regina, Sutcliffe, James,, Bourgeron, T., G. Nygren, Fred Volkmar, Posey, David J., Kolevzon, A., Nadine M Melhem, Soorya, Latha, Hallmayer, J., Scherer, Stephen,, Pericak-Vance, Margaret A., Jonathan L Haines, N. M. Melhem, Thomas Bourgeron, Haines, Jonathan L, A. Tryfon, D. Sato, R. Anney, L. Cochrane, Katherine Tansey, Vieland, Veronica, J., J. Hallmayer, Fernandez, Bridget, A., Sheffield, V.C., Liu, X.Q., Duketis, E., Cook, Edwin, H., Lotspeich, Linda, K. Tansey, Abrahams, Brett, S., Correia, C., L. Senman, Gillian Baird, Jessica Brian, de Jonge, Maretha, R. M. Cantor, Daisuke Sato, Chu, Su,, Lionel, Anath,, Annette Estes, J. Brian, Schellenberg, Gerard D, J. Salt, Wittemeyer, K., Kerstin Wittemeyer, C. Gillberg, Salt, J., Brennan, S., Cantor, Rita M, Zwaigenbaum, L., Albert Chenevier, Susan E Folstein, Christopher J Mcdougle, Kim, Cecilia, Elizabeth A Heron, Duque, Frederico, Brennan, Sean, Sousa, Inês, Nurnberger, John,, Estes, Annette, Buxbaum, Joseph, D., Katerina Papanikolaou, K. Wing, J. Almeida, O. Korvatska, Tsiantis, John, D. H. Geschwind, Carson, Andrew, R., Corsello, Christina, H. Coon, Leventhal, Bennett L, Baird, Gillian, Oliveira, G., Wassink, Thomas H., Dalila Pinto, Inês Sousa, T. Berney, Mirza, Ghazala,, McDougle, Christopher J, E. Bacchelli, Wang, Zhouzhi, Gudrun Nygren, Klauck, Sabine, M., Paterson, Andrew, D., Carson, Andrew R., van Engeland, Herman, Klauck, Sabine,, Klei, L., Bierut, Laura J., Tiago R Magalhaes, S. F. Nelson, Posey, David J, Tryfon, A., W. Mahoney, C. Corsello, Paterson, Andrew,, Leventhal, Bennett,, Jonathan Green, Vicente, A.M., J. I. Nurnberger, Howe, Jennifer L, McDougle, C.J., A. J. Bailey, Pericak-Vance, Margaret Ann, Rickaby, Jessica, Gerard D Schellenberg, Lamb, Janine A, Cuccaro, Michael, L., Sheffield, Val, C., Migita, Ohsuke, J. Gilbert, Wijsman, Ellen,, Mahoney, William, J. A. Lamb, K. Wittemeyer, Roberts, Wendy, Eftichia Duketis, Minshew, Nancy J, Wallace, S., Sato, Daisuke, Geschwind, Daniel,, Miller, Judith, Roberts, W., Maestrini, E., F. Poustka, Michael Gill, osey, David J., Hill, M., V. C. Sheffield, Jane Mcgrath, Conroy, Judith, J. Green, Boelte, Sven, H. Van Engeland, Vlad Kustanovich, C. J. McDougle, H. McConachie, Lund, S.C., Jeremy Goldberg, Merikangas, Alison, Scherer, S.W., Bierut, Laura,, J. D. Buxbaum, Hughes, Gillian, Volkmar, Fred, Betancur, C., Thomson, S., Carine Mantoulan, Strawbridge, C., Fernandez, Bridget,, Cuccaro, Michael,, Naisha Shah, Wittemeyer, Kerstin, Miller, J., Chu, S.H., Guter, Stephen J., Cuccaro, Michael L., Buxbaum, Joseph D, Vincent, John,, Simon Wallace, Heron, Elizabeth A., Coon, H., Heron, E.A., Louise Gallagher, Zwaigenbaum, Lonnie, Ann Le Couteur, Bölte, S., G. D. Schellenberg, Piven, J., Vieland, Veronica,, Sutcliffe, James S, Sousa, I., A. C. Lionel, Buxbaum, Joseph D., Vicente, Astrid,, Sykes, N., Freitag, C.M., Almeida, J., Roge, B., Howe, Jennifer, L., de Jonge, M., Pagnamenta, A.T., M. L. Cuccaro, Mantoulan, C., Poustka, F., McMahon, W.M., Anney, R., A. D. Paterson, Folstein, Susan E, Vincent, John, B., Green, J., Pagnamenta, Alistair,, Wang, K., Lionel, Anath C., Jeff Munson, Rutter, Michael L., Wassink, Thomas,, Yaspan, B.L., Michael L Rutter, Bierut, Laura Jean, Matthew Hill, Brian, J., John B Vincent, Laura J Bierut, Janine A Lamb, Annemarie Poustka, Joachim Hallmayer, Wassink, T.H., Stoppioni, V., Zurawiecki, Danielle, M., Magalhães, Tiago R., Ragoussis, J., Segurado, R., E. H. Cook, Fernandez, B.A., Catalina Betancur, Parr, Jeremy,, Bolshakova, Nadia, Mahoney, W., Vincent, John B, Leventhal, B.L., Scherer, Stephen W, P. F. Bolton, Sato, D., A. Battaglia, E. Fombonne, J. Goldberg, B. Roge, Posey, David,, Anthony P Monaco, Gilbert, John, Farrar, P., Christina Corsello, Haines, Jonathan L., Vanessa Hus, Wijsman, Ellen M, Berney, Tom, Pericak-Vance, Margaret, A., Hakonarson, H., Gillberg, Christopher, E. A. Heron, D. J. Posey, William M Mcmahon, Jessica Rickaby, Lamb, Janine,, Lambertus Klei, Lili Senman, Lotspeich, L., Rice, J.P., Nurnberger Jr, J.I., Korvatska, O., Heron, Elizabeth,, McConachie, H., M. Gill, Vicente, Astrid M, A. R. Carson, Paterson, Andrew D., John P Rice, Lord, Catherine, Volkmar, F., B. A. Fernandez, Gilbert, J., Vieland, V.J., Bourgeron, Thomas, Schellenberg, Gerard D., Rutter, Michael L.; id_orcid, Bacchelli, Elena, J. S. Sutcliffe, A. Merikangas, Wijsman, Ellen M., Freitag, Christine,, Thiruvahindrapduram, Bhooma, Rice, John P, Carson, A.R., Le Couteur, A., Pericak-Vance, Margaret,, Lamb, Janine A.; id_orcid, Sheffield, Val C., Ohsuke Migita, Mirza, Ghazala, K., Papanikolaou, Katerina, Schellenberg, Gerard, D., Schellenberg, G.D., McMahon, William M., Senman, L., Val C Sheffield, K. Sansom, Strawbridge, Christina, Monaco, Anthony P., E. Duketis, Gillberg, C., Haines, J.L., Lund, Sabata C, Segurado, Ricardo, Green, Jonathan; id_orcid, G. Oliveira, A. P. Thompson, Stoppioni, Vera, Zurawiecki, Danielle,, Parrini, B., I. Sousa, Kathryn Roeder, J. L. Howe, Papanikolaou, K., Ennis, Sean, Tryfon, Ana, B. Parrini, A. Noor, Igliozzi, Roberta, Merikangas, A., Christina Strawbridge, Chu, Su, H., Maestrini, Elena, Vicente, Astrid, M., Yaspan, Brian,, Guillermo Casallo, Parr, Jeremy, R., Geschwind, D.H., Patrick F Bolton, Lionel, A.C., Magdalena Laskawiec, A. T. Pagnamenta, Bierut, Laura, J., C. Noakes, Bhooma Thiruvahindrapduram, Cantor, Rita, M., Dawson, Geraldine, Ricardo Segurado, Tansey, Katherine E., Thomson, Susanne, Bennett L Leventhal, McDougle, Christopher J., Glessner, J.T., Chu, Su H, Edwin H Cook, Sean Brennan, Poustka, A., Folstein, Susan,, Bernie Devlin, Lionel, Anath C, Crawford, Emily, L., E. L. Crawford, Coon, Hilary, E. M. Wijsman, Bailey, A.J., Bölte, Sven, Paton, Tara, B. S. Abrahams, Freitag, Christine M., Buxbaum, J.D., Lionel, Anath, C., Mirza, Ghazala K, Sabata C Lund, Freitag, Christine, M., Catherine Lord, Gillberg, Christopher,, Wallace, Simon, Nelson, Stanley F, Cecilia Kim, Abdul Noor, Minshew, Nancy J., D. Zurawiecki, Correia, Catarina, R. Tancredi, Bridget A Fernandez, S. C. Lund, Sven Bö Lte, Fombonne, E., Bernadette Roge, Anney, Richard, Holt, R., T. Bourgeron, Berney, T., Glessner, Joseph, T., Andrew R Carson, Wood, Shawn, Casallo, Guillermo, Glessner, Joseph T, Raffaella Tancredi, Vera Stoppioni, Heron, Elizabeth, A., Christian R Marshall, Andrew Pickles, Fernandez, Bridget A, Crawford, Emily,, T. Paton, J. B. Vincent, Bolton, Patrick, F., Lonnie Zwaigenbaum, Stanley F Nelson, Astrid M Vicente, Eric Fombonne, Stephen J Guter, B. Devlin, Sheffield, Val,, Howe, Jennifer L., Olena Korvatska, Pagnamenta, Alistair T., Almeida, Joana, Thiruvahindrapduram, B., Crossett, Andrew, Cochrane, L., Thompson, Ann,, Jillian Casey, Minshew, N.J., Brian, Jessica, Engeland, Herman van, L. Zwaigenbaum, Ennis, S., Monaco, A.P., Devlin, Bernie, Katy Renshaw, Bolton, Patrick,, Irene Drmic, Bolton, Patrick F., A. Poustka, G. Dawson, Carolyn Noakes, 49, Howe, Jennifer,, Latha Soorya, M. Laskawiec, Bailey, Anthony J., Duque, F., L. J. Bierut, Aparna Prasad, Hus, Vanessa, Sansom, Katherine, Alistair T Pagnamenta, Klauck, S.M., Duketis, Eftichia, L. Soorya, Roberta Igliozzi, Wood, S., Piven, Joseph, Nelson, Stanley,, Veronica J Vieland, C. Betancur, Monaco, Anthony,, Yaspan, Brian L, Abrahams, Brett S., Laskawiec, M., S. M. Klauck, McGrath, Jane, G. Hughes, Gill, M., Nelson, Stanley F., Geschwind, Daniel, H., Geraldine Dawson, Cook, Edwin H, Roge, Bernadette, Sykes, Nuala, Heron, Elizabeth A, Marshall, Christian R, Anthony J Bailey, Melhem, Nadine,, Marshall, Christian, R., Crossett, A., Prasad, Aparna, Christine M Freitag, Pericak-Vance, Margaret A, Paton, T., A. P. Monaco, A. Estes, Thomas H Wassink, Herman Van Engeland, Sutcliffe, James S., C. M. Freitag, Joana Almeida, Guter, Stephen J, Z. Wang, Brian L Yaspan, Shah, Naisha, A. Pickles, Sutcliffe, James, S., J. Ragoussis, Frederico Duque, Lamb, Janine A., Bierut, Laura J, Dawson, G., Roeder, K., McMahon, William M, Sheffield, Val C, Green, Jonathan, Scherer, Stephen, W., Elena Bacchelli, D. Pinto, Tancredi, R., Fritz Poustka, Linda Lotspeich, Nurnberger, John I, Parr, Jeremy R., Kustanovich, V., Richard Delorme, A. Le Couteur, Igliozzi, R., Mirza, G.K., Crawford, Emily L, Kai Wang, Magalhaes, T.R., Betancur, Catalina, J. Piven, Hill, Matthew, Geschwind, Daniel H., Tara Paton, Leventhal, Bennett L., J. R. Parr, Jonge, Maretha de, Minshew, Nancy, J., William Mahoney, McConachie, Helen, Kim, C., Fombonne, Eric, Xiao-Qing Liu, S. Wallace, Hakon Hakonarson, Sabine M Klauck, K. Roeder, Barbara Parrini, Kolevzon, Alexander, S. Ennis, Nelson, S.F., John Gilbert, Crawford, Emily L., Corsello, C., Marshall, Christian,, Poustka, Fritz, Zurawiecki, Danielle, Conroy, J., Monaco, Anthony P, Gallagher, Louise, Bailey, Anthony,, Cuccaro, M.L., S. Brennan, Lord, C., Devlin, B., Pagnamenta, Alistair T, J. Munson, K. Papanikolaou, Parr, J.R., Shah, N., Nygren, G., Pagnamenta, Alistair, T., Abrahams, Brett S, Michael L Cuccaro, Wang, Kai, Regan, R., Parr, Jeremy R, J. Casey, Renshaw, Katy, Sean Ennis, Vieland, Veronica J., P. Szatmari, Ana Tryfon, John Tsiantis, Nuala Sykes, P. Farrar, Leventhal, Bennett, L., Delorme, R., Richard Holt, Haines, Jonathan, L., Oliveira, Guiomar, Cantor, Rita,, Battaglia, Agatino, Drmic, Irene, Lajonchere, Clara M, Susanne Thomson, Farrar, Penny, X.-Q. Liu, Minshew, Nancy,, Paterson, A.D., Casey, Jillian, Liu, Xiao-Qing, S. Bolte, C. Mantoulan, A. Prasad +843 morecore +1 more sourceThe prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics [PDF]
, 2010 Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the ‘core’ disorder in the classification systems.Nurit Yirmiya, Yirmiya, Nurit, Charman, Tony; id_orcid, Charman, Tony, Tony Charman +4 morecore +1 more sourceElectroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii +14 morewiley +1 more sourceEnhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao +8 morewiley +1 more sourceA Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior
Advanced Science, EarlyView.The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet +32 morewiley +1 more sourceFunctional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery
Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche +14 morewiley +1 more source
