Results 221 to 230 of about 629,954 (346)

Steroid‐Free Remission of Eosinophilic Granulomatosis With Polyangiitis Achieved With Low‐Dose Mepolizumab: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 4, April 2026.
Successful steroid‐free remission of MPO‐ANCA‐negative eosinophilic granulomatosis with polyangiitis (EGPA). Due to concurrent poorly controlled diabetes, standard high‐dose glucocorticoids were avoided. Low‐dose mepolizumab (100 mg/month) monotherapy was initiated, resulting in rapid eosinophil reduction, resolution of pulmonary infiltrates, and ...
Suzuka Matsuoka   +7 more
wiley   +1 more source

Ultrastructural Mucosal Response to Dupilumab in Chronic Rhinosinusitis With Nasal Polyps: A Pilot Study

open access: yesClinical and Translational Allergy, Volume 16, Issue 4, April 2026.
ABSTRACT Background As monoclonal antibodies have proven effective in managing recalcitrant chronic rhinosinusitis with nasal polyps (CRSwNP), the concept of disease remission is evolving, underscoring the need for a comprehensive, multimodal evaluation of disease burden over time.
Francesco Giombi   +12 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

open access: yesComprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu   +11 more
wiley   +1 more source

Quantification of Age and Sex Ratio Differences between Trial and Target Population for New Drugs

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1105-1111, April 2026.
Clinical trials are essential to understand the benefit‐harm profile of new drugs. Lack of adequate representation in age and sex ratio in clinical trials can result, for example, in higher side effects for underrepresented patients. We quantified differences in age and sex ratios between trial and target populations of new drugs approved by the FDA ...
Miquel Serra‐Burriel   +2 more
wiley   +1 more source

Alpha-1 Antitrypsin Deficiency and Bronchial Asthma: Current Challenges. [PDF]

open access: yesBiomolecules
Lopez-Campos JL   +3 more
europepmc   +1 more source

Wirsungocele as a Rare Cause of Recurrent Pancreatitis: Etiology and Therapeutic Insights

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Wirsungocele, a cystic dilation at the end of the main pancreatic duct, is associated with recurrent acute pancreatitis. A 52‐year‐old man presented to our hospital with recurrent epigastric pain over an 8‐month period with a history of multiple medical visits for the same complaint.
Sorano Ichiya   +8 more
wiley   +1 more source

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