Results 241 to 250 of about 619,857 (348)

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1889-1899, December 2025.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

A Case of Malignant Airway Obstruction Mimicking Bronchial Asthma. [PDF]

Respirol Case Rep
Matsuo Y, Takigawa Y, Sato K, Kudo K, Watanabe H, Sato A, Fujiwara K, Shibayama T.   +7 more
europepmc   +1 more source

High Remission Rate in Eosinophilic Chronic Rhinosinusitis Following More Than Two Years of Dupilumab Therapy

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 6, December 2025.
ABSTRACT Objective This study aimed to evaluate the clinical remission rate and changes in medication use in patients with eosinophilic chronic rhinosinusitis (ECRS) treated with dupilumab for > 2 years. Methods This retrospective study included 19 patients with ECRS who received dupilumab therapy for > 2 years. The nasal polyp, Lund–Mackay on sinus CT,
Seiichiro Kamimura, Keisuke Ishitani, Ryota Morozumi, Tatsuya Fujii, Yoshiaki Kitamura   +4 more
wiley   +1 more source

Diabetes-inducing effects of bronchial asthma. [PDF]

World J Diabetes
Al-Beltagi M, Bediwy AS, Saeed NK, Bediwy HA, Elbeltagi R.   +4 more
europepmc   +1 more source

Impact of Dust Storms on Airborne Bacteria, Heavy Metals, and Inflammatory Markers in Asthmatic Patients

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Dust storms in Iraq elevate airborne heavy metals (As, Ag, Ba, and so on) and alter microbial communities, exacerbating allergic inflammation (IL‐4/IL‐8) in asthmatics. Metagenomics reveals storm‐driven shifts in dominant bacteria (e.g., Burkholderiaceae, Rhodocyclaceae), linking environmental pollution to asthma risk ABSTRACT Asthma, a chronic ...
Alaa Al‐Husseini, Majid Komijani, Rulla Sabah   +2 more
wiley   +1 more source

Psychological stress and its association with bronchial asthma in Saudi Arabia: A cross-sectional study. [PDF]

Saudi Med J
Bugis AA, Turkestani FA, Ahmed ME, Alqahtani MM, Alnafisi AK, Alamri BO, Algobayshi AM.   +6 more
europepmc   +1 more source

Tumor Necrosis Factor‐α Induces Human Bronchial Fibroblasts to Produce Cytokines: Implications for Airway Inflammation

Med Research, Volume 1, Issue 3, Page 472-475, December 2025.
ABSTRACT Pulmonary fibroblasts coordinate the progression of airway inflammation through multiple pathways. However, the role and underlying mechanisms of its subtype, bronchial fibroblasts, under TNF‐α induction remain unclear. This study found that TNF‐α was highly expressed in the airway with asthma patients.
Dong Zhang, Wei Liu, Qiuwen Chen, Tao Wang, Shasha Han, Qian Qi, Liang Dong, Xiaozhi Wang   +7 more
wiley   +1 more source

Metformin use & asthma outcomes in patients with concurrent diabetes & bronchial asthma: A systematic review & meta-analysis. [PDF]

Indian J Med Res
Kamrul-Hasan ABM, Pappachan JM, Jethwani P, Patra S, Nagendra L, Dutta D, Khan MDJ, Bhattacharya S.   +7 more
europepmc   +1 more source

Newer Drugs and Their Use in the Treatment of Bronchial Asthma

, 1979
Orhan Muren
openalex   +1 more source

Bronchial thermoplasty for moderate or severe persistent asthma in adults.

Cochrane Database of Systematic Reviews, 2014
A. Torrego, I. Solá, A. Muñoz, Marta Roqué i Figuls, J. Yepes‐Nuñez, P. Alonso-Coello, V. Plaza   +6 more
semanticscholar   +1 more source