Results 41 to 50 of about 252,536 (246)

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Kellner, Julia, Tantzscher, Juliane, Edelmann, Martin, Bergner, Albrecht, Oelmez, Hamza, Huber, Rudolf M., Fischer, Rainald   +6 more
core   +1 more source

Functional Relaxation and Guided Imagery as Complementary Therapy in Asthma: A Randomized Controlled Clinical Trial [PDF]

, 2009
Background: Asthma is a frequently disabling and almost invariably distressing disease that has a high overall prevalence. Although relaxation techniques and hypnotherapeutic interventions have proven their effectiveness in numerous trials, relaxation ...
N. Sauer, F. Röhricht, D. Nowak, Loew, T., C. Lahmann, T. Schuster, Sauer, N., Nowak, Dennis, K. Tritt, M. Nickel, T. Loew, Ronel, J., M. Noll-Hussong, Schuster, T., Tritt, K., Noll-Hussong, M., J. Ronel, Lahmann, Claas, Lahmann, C., Röhricht, F., Nickel, M., Nowak, D., Lahmann, C.;Nickel, M.;Schuster, T.;Sauer, N.;Ronel, J.;Noll-Hussong, M.;Tritt, K.;Nowak, D.;Röhricht, F.;Loew, T., Lahmann, C;Nickel, M;Schuster, T;Sauer, N;Ronel, J;Noll-Hussong, M;Tritt, K;Nowak, D;Rohricht, F;Loew, T   +23 more
core   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development [PDF]

, 2016
Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe forms of asthma. It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels
Gorlanova, Olga, Olga Gorlanova, Latzin, Philipp, Frey, Urs, Jakob Usemann, Urs Frey, Philipp Latzin, Dominik Hartl, Mack, Ines, Hartl, Dominik, Schmidt, Anne, Röösli, Martin, Ines Mack, Usemann, Jakob, Martin Röösli, Anne Schmidt   +15 more
core   +2 more sources

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Bronchial Hypereactivity in Heart Failure Patients

Majalah Kardiologi Indonesia, 2013
Incidence of paroxysmal dyspnea accompanied by wheezing and coughing is a typical picture of congestive heart failure (congestive heart failure/CHF) formerly known as cardiac asthma.
Santi R Dewayanti
doaj   +1 more source

Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Respiratory Research, 2021
Background Bronchial thermoplasty regulates structural abnormalities involved in airway narrowing in asthma. In the present study we aimed to investigate the effect of bronchial thermoplasty on histopathological bronchial structures in distinct asthma ...
Eleni Papakonstantinou, Triantafyllia Koletsa, Liang Zhou, Lei Fang, Michael Roth, Meropi Karakioulaki, Spasenija Savic, Leticia Grize, Michael Tamm, Daiana Stolz   +9 more
doaj   +1 more source

高齢者気管支喘息における気道過敏性と温泉療法 [PDF]

, 2001
Clinical effects of spa therapy were examined in 150 patients with asthma in relation tobronchial hyperresponsiveness and patient age. 1. The efficacy rate of spa therapy was larger as the patient age was higher: the rate was 73.3% in patients under age ...
Tanizaki, Yoshiro, Hosaki, Yasuhiro, Ashida, Kozo, Okamoto, Makoto, Takata, Shingo, Ochi, Koji, Mitsunobu, Fumihiro, Mifune, Takashi, Tsugeno, Hirofumi   +8 more
core   +1 more source

Expert Consensus on Influenza Vaccine and Pneumococcal Vaccination in Elderly People With Chronic Respiratory Diseases (2024)

AGING MEDICINE, EarlyView.
This consensus describes the protective effect and safety of influenza and pneumococcal vaccines, and vaccination recommendations, aiming to promote the vaccination rate, better play the role of vaccines in preventing influenza and pneumococcal diseases, and reduce the occurrence of respiratory infections and related serious complications in elderly ...
Lijing Wang, Qiao Yu, Qiong Chen, Pulin Yu, Expert Committee of Consensus Opinion on Influenza Vaccine and Pneumococcal Vaccine Vaccination for Elderly People with Chronic Respiratory Diseases, Respiratory Group of Chinese Geriatrics Society, Yunhua Bai, Yufeng Du, Luzhao Feng, Lidong Gao, Lingyun Gao, Baimei He, Junguang Jiang, Wenjing Jiang, Yayun Nan, Zhibin Peng, Yun Peng, Zhujun Shao, Jin Tan, Yingxuan Tian, Bingxiang Wang, Yuhong Wang, Wei Wu, Jianqin Wu, Xiuping Wu, Meizhe Xin, Wei Xiong, Guogang Zhang, Qiang Zhang, Xiangyu Zhang, Zhimian Zhang, Xiongwen Zhou   +31 more
wiley   +1 more source

Clinical Relevance of Plasma Concentrations of MBL in Accordance with IgE Levels in Children Diagnosed with Bronchial Asthma

Medicina, 2020
Background and objectives: Bronchial asthma is a heterogeneous, multifactorial pulmonary disease characterized by variable airway obstruction caused by chronic inflammation. Our study investigates the clinical relevance of MBL plasma levels in accordance
Simona Maria Borta, Simona Dumitra, Imola Miklos, Romana Popetiu, Luminița Pilat, Maria Pușchiță, Cătălin Marian   +6 more
doaj   +1 more source