Results 51 to 60 of about 252,536 (246)

Omalizumab: clinical use for the management of asthma [PDF]

, 2012
Omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, is a treatment option for patients with moderate to severe allergic asthma whose asthma is poorly controlled with inhaled corticosteroids and inhaled long-acting ß2 agonist ...
Rekha Chaudhuri, Neil C. Thomson, Thomson, N.C., Chaudhuri, R.   +3 more
core   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Transforming growth factor-beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response

, 2012
Rhinovirus (RV) infection is a major cause of asthma exacerbations which may be due to a deficient innate immune response in the bronchial epithelium. We hypothesized that the pleiotropic cytokine, TGF-?, influences interferon (IFN) production by primary
Green, Ben, David Sammut (137689), Gisli Jenkins (137696), Bedke Nicole, Jenkins Gisli, Stephen T Holgate, Donna E Davies, Howarth, Peter H., Nicole Bedke (137686), Sammut, David, Jenkins, Gisli, Amanda Tatler, Holgate, Stephen T., Sammut David, Ben Green, Patrick Dennison, Stephen T. Holgate (137701), Valia Kehagia, Dennison Patrick, Holgate Stephen T., David Sammut, Amanda Tatler (137698), Davies Donna E., Nicole Bedke, Donna E. Davies (137702), Bedke, Nicole, Peter H Howarth, Green Ben, Peter H. Howarth (137699), Patrick Dennison (137694), Davies, Donna E., Valia Kehagia (137692), Gisli Jenkins, Tatler, Amanda, Tatler Amanda, Howarth Peter H., Ben Green (137690), Dennison, Patrick, Kehagia, Valia, Kehagia Valia   +39 more
core   +1 more source

Caffeine for asthma [PDF]

, 2010
Background Caffeine has a variety of pharmacological effects; it is a weak bronchodilator and it also reduces respiratory muscle fatigue. It is chemically related to the drug theophylline which is used to treat asthma.
Barley, Elizabeth, Bara, Anna, Cates, Christopher J., Welsh, EJ, Welsh, Emma J., Bara, A, Barley, E, Cates, CJ   +7 more
core   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma

Journal of Pharmacological Sciences, 2010
.: Airway hyperresponsiveness to nonspecific stimuli is one of the characteristic features of allergic bronchial asthma. An elevated contractility of bronchial smooth muscle has been considered as one of the causes of the airway hyperresponsiveness.
Yoshihiko Chiba, Kimihiko Matsusue, Miwa Misawa   +2 more
doaj   +1 more source

Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.
Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu, Zhenbang Gu, Wengen Zhu, Shenghui Feng   +3 more
wiley   +1 more source

Prevalence of bronchial asthma and factors associated with it among higher secondary school children in Ernakulam district, Kerala, Southern India

Journal of Family Medicine and Primary Care, 2017
Context: Bronchial asthma is one of the leading causes of hospitalization and cause of frequent absenteeism among children and adolescents. Studies reporting the prevalence of bronchial asthma among adolescents from India are limited and the available ...
Jishnu Sathees Lalu, P S Rakesh, K Leelamoni   +2 more
doaj   +1 more source

Modern understanding of bronchial asthma with fixed airflow obstruction

Терапевтический архив, 2021
The review provides data on one of the phenotypes of severe bronchial asthma it is asthma with fixed airway obstruction. According to data published today, there is no single pathway for the formation of fixed airway obstruction in patients with severe ...
Angelina Yu. Kraposhina, Elena A. Sobko, Irina V. Demko, Anna B. Kacer, Olga V. Kazmerchuk, Yuriy I. Abramov   +5 more
doaj   +1 more source

Unifying candidate gene and GWAS Approaches in Asthma. [PDF]

, 2010
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWAS ...
Heinzmann, Andrea, Ruether, Andreas, Otto Laub, Bufe, A., Lathrop, M, Schedel, M., Michel, Sven, Ruether, A., Michel, S., Schreiber, Stefan, von Berg, A., Gut, I.G., Christian Vogelberg, Ernst Rietschel, von Mutius, E., Burkhard Simma, Schreiber, S., Klopp, N., Schedel, Michaela, Depner, Martin, Laub, O., Liang, Liming, Stefan Schreiber, Illig, T., Rietschel, E., Michael Kabesch, Gut, Ivo Glynne, Mutius, Erika von, Frischer, T., Kabesch, Michael, Kabesch, M., Lathrop, Mark, Frischer, Thomas, Ashish Kumar, Jon Genuneit, Gut, Ivo G., Albrecht Bufe, Mark Lathrop, Kumar, A., Rietschel, Ernst, Ivo G. Gut, Illig, Thomas, Martin Depner, Liming Liang, Heinzmann, A., Andrea von Berg, Laub, Otto, Thomas Illig, Andreas Ruether, Simma, B., Vogelberg, Christian, Bufe, Albrecht, Erika von Mutius, Simma, Burkhard, Ivo G Gut, Kumar, Ashish, Sven Michel, Liang, L.M., Depner, M., Berg, Andrea von, Thomas Frischer, Michaela Schedel, Genuneit, J., Genuneit, Jon, Vogelberg, C., Norman Klopp, Klopp, Norman, Andrea Heinzmann   +67 more
core   +2 more sources