Results 61 to 70 of about 619,857 (348)

Advances in the Gut-Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential. [PDF]

open access: yesClin Transl Allergy
ABSTRACT Background Bronchial asthma (hereafter referred to as asthma) is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and reversible airflow limitation. Recent advancements in the “gut‐lung” axis concept have elucidated the intricate immunometabolic crosstalk between the gastrointestinal tract
Zheng T, Huang Y, Yao H.
europepmc   +2 more sources

Patient‐Specific Coculture of S. aureus and P. aeruginosa Enhances Epithelial Barrier Disruption and Virulence in CRS

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease that is associated with polymicrobial infections, often involving S. aureus and P. aeruginosa. It is unclear whether the polymicrobial context plays a role in exacerbating epithelial damage, inflammation, and resistance to therapy. Methods S. aureus and P. aeruginosa (n =
Xiaohan Sun MMed   +6 more
wiley   +1 more source

RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma

open access: yesJournal of Pharmacological Sciences, 2010
.: Airway hyperresponsiveness to nonspecific stimuli is one of the characteristic features of allergic bronchial asthma. An elevated contractility of bronchial smooth muscle has been considered as one of the causes of the airway hyperresponsiveness.
Yoshihiko Chiba   +2 more
doaj   +1 more source

Steroid-Induced Psychosis Presenting as Alice in Wonderland Syndrome [PDF]

open access: yes, 2012
A 40 year old overweight male with a history of bronchial asthma, hypertension, and “schizophrenia” was admitted for intractable bronchial asthma. He did not have a history of drug or alcohol use.
Favazza, Frank W., M.D.   +2 more
core   +1 more source

Characteristic of Individual Indicators of Endogenous Intoxication in the Experimental Asthma Dynamics and Their Correction by Thiotriasolin [PDF]

open access: yes, 2016
The aim of this work was to find out the specifics of changes in endogenous intoxication, middle mass molecules (MMM) and erythrocyte intoxication index (EII) in the blood of animals for experimental asthma in different periods of its development and to ...
Kolishetska, M. (Marta)
core   +2 more sources

The Global Airways in Practice: Long‐term Effects of Mepolizumab With or Without FESS on Type 2 Inflammation in Patients With CRSwNP

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease often associated with asthma. The global airway hypothesis suggests bidirectional inflammatory interactions between upper and lower airways. Mepolizumab, an anti–IL‐5 therapy, treats conditions systemically, while functional endoscopic sinus surgery ...
Jens Tidemandsen   +9 more
wiley   +1 more source

Bronchial hyperresponsiveness in children with atopic rhinitis: a 7-year follow-up [PDF]

open access: yes, 2004
A high prevalence of bronchial hyperresponsiveness (BHR) was found in atopic subjects with rhinitis. Those subjects may be at higher risk for developing bronchial asthma.
Bonsignore, G.   +6 more
core   +1 more source

Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation

open access: yesEuropean Respiratory Review, 2015
This review focuses on the methods available for measuring reversible airways obstruction, bronchial hyperresponsiveness (BHR) and inflammation as hallmarks of asthma, and their role in monitoring children with asthma.
A. Moeller   +7 more
semanticscholar   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai   +8 more
wiley   +1 more source

Prevalence of bronchial asthma and factors associated with it among higher secondary school children in Ernakulam district, Kerala, Southern India

open access: yesJournal of Family Medicine and Primary Care, 2017
Context: Bronchial asthma is one of the leading causes of hospitalization and cause of frequent absenteeism among children and adolescents. Studies reporting the prevalence of bronchial asthma among adolescents from India are limited and the available ...
Jishnu Sathees Lalu   +2 more
doaj   +1 more source

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