Results 61 to 70 of about 2,305,065 (298)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Bronchial asthma is associated with increased risk of chronic kidney disease

, 2017
Background: Bronchial asthma influences some chronic diseases such as coronary heart disease, diabetes mellitus, and hypertension, but the impact of asthma on vital diseases such as chronic kidney disease is not yet verified.
李建勳, Huang, Hui-Ling;Ho, Shinn-Ying;Li, Chien-Hsun;Chu, Fang-Ying;Ciou, Li-Ping;Lee, Hua-Chin;Chen, Wen-Liang;Tzeng, Nian-Sheng   +1 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Bridging eco-exposome and one health approaches to address emerging infectious diseases through the EMERG project

Discover Public Health
Introduction Emerging or re-emerging infectious diseases (EIDs) are being increasingly reported and represent a significant burden on public health and global economies, as exemplified by COVID-19 pandemic. Context Given the current EID importance at the
Laurence Delhaes, Baptiste Defaye, Gautier Chauvin, Aurélien Mercier, Jérôme Moreau, Karine Monceau, Cristiana Cravo-Laureau, Gaelle Gonzalez, Jean-Luc Guerin, Nicolas Eterradossi, Christine Imbert, Hélène Agogué, Denis Malvy, the EMERG consortium   +13 more
doaj   +1 more source

Differential diagnosis and therapy of bronchial obstruction syndrome in children

Медицинский совет, 2015
The article is an update on the broncho-obstructive syndrome in children, its etiology and pathogenetic mechanisms. The most common causes of bronchial obstruction are characterized - acute bronchiolitis (obstructive bronchitis) and asthma; the effect of
D. Y. Ovsyannikov, D. A. Kachanova
doaj   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

NOSOTROPIC SUBSTANTIATION OF ANTI IgE ANIBODY THERAPY

Педиатрическая фармакология, 2008
This article studies the specifics of allergic diseases pathogenesis. Such common allergic diseases as bronchial asthma, allergic rhinitis and atopic dermatitis are conditioned by processes based on increase of immunoglobulin e synthesis.
Yu.G. Levina
doaj   +2 more sources

Tracheal and bronchial involvement in colitis ulcerosa – a colo-bronchitic syndrome? A case report and some additional considerations

GMS German Medical Science, 2015
Systemic involvement is well known in patients with inflammatory bowel diseases (IBD), but there are only few data looking to Crohn’s disease (CD) and ulcerative colitis (UC) separately instead of lumping together both entities to IBD.
von Wichert, Peter, Barth, Peter, von Wichert, Goetz   +2 more
doaj   +1 more source

Incidence and risk factors of contrast-induced nephropathy after bronchial arteriography or bronchial artery embolization

, 2013
Background: In uncontrolled hemoptysis patient, bronchial arteriography and bronchial artery embolization (BAE) is a important procedure in diagnosis and treatment.
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core   +1 more source