Results 71 to 80 of about 2,305,065 (298)

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Polymorphisms in the bradykinin B2 receptor gene and childhood asthma [PDF]

, 2001
Bradykinin has been suggested as one of the key mediators of bronchial asthma. Polymorphisms with a potential functional relevance have been described in the B2 bradykinin receptor gene.
Illi, S., Praun, M., Kusser, B., Braun, A., Mutius, Erika von, Roscher, A. A., E. von Mutius, A.A. Roscher, M. Praun, A. Braun, S. Illi, B. Kusser   +11 more
core   +2 more sources

Expert Consensus on Influenza Vaccine and Pneumococcal Vaccination in Elderly People With Chronic Respiratory Diseases (2024)

AGING MEDICINE, EarlyView.
This consensus describes the protective effect and safety of influenza and pneumococcal vaccines, and vaccination recommendations, aiming to promote the vaccination rate, better play the role of vaccines in preventing influenza and pneumococcal diseases, and reduce the occurrence of respiratory infections and related serious complications in elderly ...
Lijing Wang, Qiao Yu, Qiong Chen, Pulin Yu, Expert Committee of Consensus Opinion on Influenza Vaccine and Pneumococcal Vaccine Vaccination for Elderly People with Chronic Respiratory Diseases, Respiratory Group of Chinese Geriatrics Society, Yunhua Bai, Yufeng Du, Luzhao Feng, Lidong Gao, Lingyun Gao, Baimei He, Junguang Jiang, Wenjing Jiang, Yayun Nan, Zhibin Peng, Yun Peng, Zhujun Shao, Jin Tan, Yingxuan Tian, Bingxiang Wang, Yuhong Wang, Wei Wu, Jianqin Wu, Xiuping Wu, Meizhe Xin, Wei Xiong, Guogang Zhang, Qiang Zhang, Xiangyu Zhang, Zhimian Zhang, Xiongwen Zhou   +31 more
wiley   +1 more source

Generation of the induced pluripotent stem cell line UHOMi002-A from peripheral blood mononuclear cells of a healthy male donor

Stem Cell Research, 2020
Human pluripotent stem cells (hiPSC) are highly valuable tools to model lung development and chronic bronchial diseases. We generated a hiPSC line from a highly characterized 40-year-old healthy male nonsmoking donor.
Mathieu Fieldes, Engi Ahmed, Chloé Bourguignon, Joffrey Mianné, Mélanie Martin, Cécile Arnould, Isabelle Vachier, Said Assou, John De Vos, Arnaud Bourdin   +9 more
doaj   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study

Frontiers in Psychiatry, 2018
Background/objectiveAllergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that allergic diseases were associated with depression or anxiety disorders.
Nian-Sheng Tzeng, Nian-Sheng Tzeng, Hsin-An Chang, Hsin-An Chang, Chi-Hsiang Chung, Chi-Hsiang Chung, Chi-Hsiang Chung, Yu-Chen Kao, Yu-Chen Kao, Chuan-Chia Chang, Hui-Wen Yeh, Hui-Wen Yeh, Hui-Wen Yeh, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Ching Chou, Shan-Yueh Chang, Shan-Yueh Chang, Wu-Chien Chien, Wu-Chien Chien, Wu-Chien Chien   +20 more
doaj   +1 more source

Bronchoscopy Robot with Enhanced Flexibility and Stability via Multi‐Segment Variable Stiffness Catheter

Advanced Intelligent Systems, EarlyView.
This work presents a magnetic bronchoscopy robot with a novel multi‐segment variable stiffness catheter. This catheter can not only move flexibly in the narrow bronchi but also harden according to the need to provide support. Combined with remote wireless magnetic field drive, it provides a more precise and effective solution for biopsy of deep lung ...
Shucong Yin, Bin Huang, Shiyuan Dong, Junhao Wang, Liangshen Zhao, Yang Yang, Bingkun Bao, Hongen Liao, Fang Chen, Tianqi Huang, Boyu Zhang   +10 more
wiley   +1 more source

Spectrum of Congenital Anomalies in Myhre Syndrome—Insights Into Effects Brought by Altered TGF‐β Signaling via Gain‐of‐Function Variants in SMAD4

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is a rare genetic disorder characterized by progressive multisystem involvement. Gain‐of‐function missense heterozygous variants affecting the Ile500 residue and Arg496 residue of the SMAD4 gene are implicated in this condition.
Kawmadi Gunawardena, Alessandro De Falco, Deborah Osio, Eleanor Sherlock, Emma Kivuva, Erina Sasaki, Francis H. Sansbury, Nayana Lahiri, Patricia Foley, Sahar Mansour, Shane McKee, Tazeen Ashraf, Nicola Brunetti‐Pierri, Usha Kini   +13 more
wiley   +1 more source

Correlation between clinical symptoms and forced expiratory volume in one second (FEV1) in patients of chronic obstructive pulmonary disease and asthma

MRIMS Journal of Health Sciences, 2019
Background: Chronic obstructive pulmonary disease and Bronchial Asthma are the major causes of pulmonary disability. These diseases are characterized by airway obstruction.
A Vinay Kumar, K Raj Kumar, K Sai Samrat
doaj   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source