Results 101 to 110 of about 83,414 (306)

[Bronchoalveolar lavage fluid findings in rheumatoid arthritis].

Nihon Kyobu Shikkan Gakkai zasshi, 1992
Findings of bronchoalveolar lavage fluid (BALF) were compared among three groups of patients: rheumatoid arthritis (RA) with or without interstitial lung disease (ILD), and collagen disease other than RA accompanied by ILD. Regardless of the presence or absence of associated ILD, the RA groups showed higher numbers of neutrophils in BALF with a mean ...
Ishioka, Shinichi, Inyaku, Kyosuke, Shirotani, Yoshifumi, Nakamura, Kimihiko, Oyama, Tetsu, Hozawa, Soichiro, Takahashi, Kouichi, Yamakido, Michio   +7 more
openaire   +2 more sources

Anti‐Allergic Potential of Chamaecrista nomame and Its Compound Luteolin for Novel Asthma Therapy

Phytotherapy Research, EarlyView.
Chamaecrista nomame (CN) and its active compound luteolin attenuate allergic airway inflammation by inhibiting mast cell activation and suppressing NF‐κB/MAPK signaling, leading to reduced cytokine production and OVA‐specific IgE levels. ABSTRACT Asthma is a chronic inflammatory disease driven by dysregulated immune responses and mast cell activation ...
Tae Kyeom Kang, Myungsuk Kim, Tam Thi Le, Geon Park, Yuna Jung, Hyobin Jeong, Youngsang Yoo, Wook‐Bin Lee, Sang Hoon Jung   +8 more
wiley   +1 more source

Baseline Neutrophil‐To‐Lymphocyte Ratio as a Risk Stratification Marker for Severe Checkpoint Inhibitor Pneumonitis in Patients With Non‐Small Cell Lung Cancer: A Two‐Cohort Study With Retrospective Discovery and Prospective Validation

Respirology, EarlyView.
The association between baseline neutrophil‐to‐lymphocyte ratio (NLR) and severe checkpoint inhibitor pneumonitis (CIP) was analyzed in discovery retrospective and validation prospective cohorts. Higher baseline NLR (≥ 4.75) was associated with increased severe CIP incidence in both cohorts.
Tetsu Hirakawa, Kakuhiro Yamaguchi, Shun Takao, Nobuhiro Kanaji, Naoko Matsumoto, Kozue Miyazaki, Tamio Okimoto, Chihiro Ando, Hisao Higo, Masaaki Yanai, Koji Kurose, Yasunari Nagasaki, Masako Watanabe, Kosuke Oyama, Yuko Toyoda, Yoshihiro Taguchi, Shimpei Tada, Kiyofumi Shimoji, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori   +24 more
wiley   +1 more source

Bacterial Outer Membrane Vesicles Induce Vitronectin Release Into the Bronchoalveolar Space Conferring Protection From Complement-Mediated Killing

Frontiers in Microbiology, 2018
Pathogens causing pneumonia utilize the complement regulator vitronectin to evade complement-mediated killing. Although vitronectin is associated with several chronic lung diseases, the role of bronchoalveolar vitronectin in pneumonia has not been ...
Magnus Paulsson, Karlhans F. Che, Jonas Ahl, Johan Tham, Linda Sandblad, Margaretha E. Smith, Ingemar Qvarfordt, Yu-Ching Su, Anders Lindén, Anders Lindén, Kristian Riesbeck   +10 more
doaj   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Fungi identified via next-generation sequencing in bronchoalveolar lavage fluid among patients with COVID-19: a retrospective study

European Journal of Medical Research
Background The epidemiology of fungi identified via next-generation sequencing in bronchoalveolar lavage fluid among patients with COVID-19 is unknown.
Xiaobo Yang, Xuehui Gao, Hongling Zhang, Jiqian Xu, You Shang   +4 more
doaj   +1 more source

Mast cell and histamine content of human bronchoalveolar lavage fluid

, 1985
Bronchoalveolar lavage was performed in 97 patients including control patients with bronchial carcinoma (24) and patients with sarcoidosis (20), cryptogenic fibrosing alveolitis (9), and asthma (4), and others.
Agius, Raymond M., Godfrey, Richard C., Holgate, Stephen T.   +2 more
core   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Characterization of the innate immune response to chronic aspiration in a novel rodent model

Respiratory Research, 2007
Background Although chronic aspiration has been associated with several pulmonary diseases, the inflammatory response has not been characterized. A novel rodent model of chronic aspiration was therefore developed in order to investigate the resulting ...
Lin Shu S, Yoon Yonghan, Cantu Edward, Hsieh Chong-Chao, Li Bin, Hartwig Matthew G, Lee Sean M, Appel James Z, Parker William, Davis R Duane   +9 more
doaj   +1 more source