Results 111 to 120 of about 83,414 (306)

Rickettsia felis Pulmonary Infection Detected via Metagenomic Next-Generation Sequencing in a Clonorchiasis Patient: A Case Report

Infection and Drug Resistance
Sha Wen,* Jing-Jing Zeng,* Ying Li Department of Critical Care Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, People’s Republic of China*These authors contributed equally to this ...
Wen S, Zeng JJ, Li Y
doaj  

MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation

Allergy, EarlyView.
In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata, Jaclyn W. McAlees, Julie M. Hargis, Archana Shankar, Shouxiong Huang, Senad Divanovic, Ian P. Lewkowich   +6 more
wiley   +1 more source

Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma

Allergy, EarlyView.
EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro, Ian D. Pavord, Klaus F. Rabe, Elizabeth Laws, Alexandre Jagerschmidt, Kaitlyn Gayvert, Sivan Harel, Jennifer D. Hamilton, Nikhil Amin, Lu Zhang, Heming Xing, Anissa Elfakir, Bema Coulibaly, Souâd Naimi, Sara Hamon, Paul J. Rowe, Frank Nestle, Danen M. Cunoosamy, Emanuele de Rinaldis, Leda P. Mannent   +22 more
wiley   +1 more source

Intraindividual variability of bronchoalveolar lavage fluid findings in healthy never-smoking subjects.

, 2013
Intraindividual variability of bronchoalveolar lavage fluid findings in healthy never-smoking subjects.
Anders Eklund (177880), Göran Tornling (309161), Johan Grunewald (177876), C. Magnus Sköld (191636), Helga H. Olsen (309160)   +4 more
core   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

The role of eCyPA as an inflammatory biomarker for predicting 28-day mortality in ARDS patients

Respiratory Research
Background Acute respiratory distress syndrome (ARDS) is the primary manifestation of systemic inflammatory response syndrome in the lungs. Extracellular cyclophilin A (eCyPA) as a novel inflammatory marker, this study aims to investigate the expression ...
Juan Chen, Xue Dai, Jing Lv, Meijun Liu, Ewan C. Goligher, Wang Deng   +5 more
doaj   +1 more source

Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease

Mediators of Inflammation, 2001
Background: In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone.
Gert T. Verhoeven, Ingrid M. Garrelds, Henk C. Hoogsteden, Freek J. Zijlstra   +3 more
doaj   +1 more source

Pathophysiological and Molecular Features of DXd ADC‐Related Interstitial Pneumonitis in Cynomolgus Monkeys

Cancer Science, EarlyView.
An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai, Takuma Iguchi, Kentaro Kubota, Ken Sakurai, Yoshimi Tsuchiya, Katsuyoshi Chiba   +5 more
wiley   +1 more source

DIAGNOSTIC ACCURACY OF GENEXPERT ASSAY AND COMPARISON WITH SMEAR AFB ON BRONCHIAL WASHINGS IN SPUTUM NEGATIVE SUSPECTED PULMONARY TUBERCULOSIS

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine diagnostic accuracy of GeneXpert Assay and compare it with smear microscopy for AFB in terms of sensitivity, specificity on bronchial washings/bronchoalveolar lavage samples in sputum smear negative suspected tuberculosis ...
Mahmood Iqbal Malik, Taymmia Ejaz, Jamal Ahmed, Komal Arshad, Yousaf Jamal, Zeenat Zohfreen   +5 more
doaj  

Correlation with age for bronchoalveolar lavage fluid findings in healthy never-smoking subjects.

, 2013
Correlation with age for bronchoalveolar lavage fluid findings in healthy never-smoking subjects.
Anders Eklund (177880), Göran Tornling (309161), Johan Grunewald (177876), C. Magnus Sköld (191636), Helga H. Olsen (309160)   +4 more
core   +1 more source