Results 151 to 160 of about 75,505 (263)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

open access: yesAdvanced Science, Volume 13, Issue 56, 9 October 2026.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li   +15 more
wiley   +1 more source

Cavitary Pulmonary Adenocarcinoma in a Young Adult With a History of Treated Hodgkin Lymphoma: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Cavitary lung lesions are commonly attributed to infection; however, malignancy should remain a diagnostic consideration. We report a 30‐year‐old non‐smoking man with a history of treated Hodgkin lymphoma who presented with a cavitary pulmonary adenocarcinoma. This case highlights the importance of considering rare malignant causes.
Hosam Aldalbahi, Nora Ahmed Bedaiwi
wiley   +1 more source

Fulminant Multisystem IgA Vasculitis With Diffuse Alveolar Hemorrhage, Severe Gastrointestinal Hemorrhage, Paralytic Ileus, and Renal Involvement in an Adolescent: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 17‐year‐old girl with IgA vasculitis developed diffuse alveolar hemorrhage, severe gastrointestinal hemorrhage with paralytic ileus, and clinical renal involvement. Early bronchoscopy demonstrated diffuse airway bleeding, supported the diagnosis, enabled microbiological sampling, and informed postponement of pharmacological ...
Xianzhang Shan, Yancui Zhu
wiley   +1 more source

Bioassays in Allergy: Technical Characteristics, Limitations, and Pathways to Clinical Implementation—An EAACI Position Paper

open access: yesClinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Bioassays offer functional readouts of immune responses through specific biomarkers, providing mechanistic insight beyond conventional serology. By capturing cellular activation, tissue‐level changes, and molecular signaling, they hold promise for refining allergy diagnosis, risk stratification, and treatment monitoring, contributing to ...
Cagatay Karaaslan   +13 more
wiley   +1 more source

Sinensetin From Citrus Peel Alleviates LPS‐Induced Acute Pneumonia by Regulating HIF‐1α Signaling Pathway in Mice

open access: yeseFood, Volume 7, Issue 5, October 2026.
In this study, we found that sinensetin can effectively inhibit the inflammatory response and damage of lung cells caused by LPS in vivo and in vitro. This might be caused by the action of sinensetin in regulating the HIF‐1α‐MAPK signaling cascade.
Zuomin Hu   +9 more
wiley   +1 more source

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