Results 51 to 60 of about 127,822 (311)

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health.

Journal of Proteome Research, 2014
Acute respiratory distress syndrome (ARDS) remains a significant hazard to human health and is clinically challenging because there are no prognostic biomarkers and no effective pharmacotherapy.
Charles R. Evans, A. Karnovsky, M. Kovach, T. Standiford, C. Burant, K. Stringer   +5 more
semanticscholar   +1 more source

Kinetics of microRNA Expression in Bronchoalveolar Lavage Fluid Samples [PDF]

Lung, 2015
Levels of microRNAs (miRNAs) are increasingly assessed in biological fluids, for example, in samples obtained by bronchoalveolar lavage (BAL). "Post-collection kinetics" of miRNA expression levels, however, have not been investigated to date. In these experiments, we analyzed the dynamic expression profile of 5 different miRNAs (miR-17, miR-19b, miR ...
Brock Matthias, Rechsteiner Thomas, Kohler Malcolm, Franzen Daniel, Huber Lars C.   +4 more
openaire   +4 more sources

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Nested–polymerase chain reaction detection of f. sp. in a suspected immunocompromised Cavalier King Charles spaniel with multiple infections

SAGE Open Medical Case Reports, 2019
A 7-month-old Cavalier King Charles Spaniel female was referred due to a chronic cough refractory to antibiotic treatments. Laboratory findings showed leukocytosis, increased serum C-reactive protein, hypogammaglobulinemia, and decreased total serum ...
Matteo Petini, Tommaso Furlanello, Patrizia Danesi, Andrea Zoia   +3 more
doaj   +1 more source

Expression of complement-related membrane proteins on lymphocytes and alveolar macrophages in bronchoalveolar lavage fluid

Allergology International, 1998
Interstitial lung disease (ILD) can be separated into two groups: (i) that in which the causes are known; and (ii) that in which the etiologies have not been determined.
Risa Nakahara, Shuhei Takemura, Hideki Onodera, Yoshihiro Kasamatsu, Nobuyuki Seto, Naoko Ichio, Takashi Doi, Sadanobu Nakanishi, Masayuki Okamoto, Kunio Yanagida, Masahiro Ueda, Masako Deguchi, Motoharu Kondo   +12 more
doaj   +1 more source

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

Advanced Science, EarlyView.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan, Zhengnan Ren, Binbin Li, Wenjie Liang, Yang Luo, Qin Yang, He Liu, Xiaoliang Dong, Haizhi Tian, Huimin Zou, Bengt Samuelsson, Olof Rådmark, Jia Sun   +12 more
wiley   +1 more source

Effect of Lavage Solution Type on Bronchoalveolar Lavage Fluid Cytology in Clinically Healthy Horses

Animals, 2023
Equine bronchoalveolar lavage (BAL) is usually performed with 250–500 mL of isotonic saline at pH 5.5. The acidic pH of saline may cause an increase in airway neutrophil count 48 h after BAL.
Cornélie M. Westermann, Annelieke G. de Bie, Carla Olave, Janny C. de Grauw, Erik Teske, Laurent L. Couetil   +5 more
doaj   +1 more source

Bronchoalveolar Lavage Fluid IFN-γ + Th17 Cells and Regulatory T Cells in Pulmonary Sarcoidosis

Mediators of Inflammation, 2014
In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN-γ have been observed in peripheral blood.
A. Tøndell, T. Moen, M. Børset, Ø. Salvesen, A. D. Rø, M. Sue-Chu   +5 more
semanticscholar   +1 more source

Chemokines in the Bronchoalveolar Lavage Fluid of Patients with Sarcoidosis.

Internal Medicine, 1997
We measured the levels of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in the bronchoalveolar lavage (BAL) fluids from 27 patients with active pulmonary sarcoidosis and examined the relationship between chemokine levels and some clinical manifestations.
Tadashi Kasahara, Kouji Matsushima, Naofumi Mukaida, Yukihiko Sugiyama, Satoshi Kitamura   +4 more
openaire   +4 more sources