Results 21 to 30 of about 16,717 (172)

Experimental evaluation of the nonselective and selective TMEM16 family calcium-activated chloride channel blockers in the airways

European Pharmaceutical Journal, 2023
The family of calcium-activated chloride channels, TMEM16, plays a significant role in contributing to the pathogenesis of airway inflammatory diseases.
Mažerik J., Smieško L., Fedorová L., Gondáš E.   +3 more
doaj   +1 more source

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

FASEB BioAdvances, 2020
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling   +14 more
doaj   +1 more source

Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma

Physiological Reports, 2023
We determined the effect of exercise‐induced bronchoconstriction (EIB) on the shape of the maximal expiratory flow‐volume (MEFV) curve in asthmatic adults. The slope‐ratio index (SR) was used to quantitate the shape of the MEFV curve.
Oksana Klimenko, Peter Luu, Paolo Dominelli, Nathan Noggle, Gregory Petrics, Hans Christian Haverkamp   +5 more
doaj   +1 more source

Possibility of lipid microsphere-encapsulated Y-24180 as an injectable drug and an inhaler for the treatment of bronchoconstriction

Allergology International, 2000
Y-241 80 ((±)-4-(2-chloro-phenyl)-2-[2-(4-isobuthyl- phenyl)ethyl]-6,9-dimethyl-6H-thieno[3,2f][1,2,4] triazolo[4,3-a)[1,4]diazepine) is a lipophilic platelet- activating factor (PAF) antagonist.
Mitsuko Takenaga, Rie Igarashi, Yutaka Mizushima   +2 more
doaj   +1 more source

Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

Journal of Asthma and Allergy, 2021
Mark F McCarty,1 James J DiNicolantonio,2 Aaron Lerner3 1Catalytic Longevity Foundation, San Diego, CA, USA; 2Department of Preventive Cardiology, Saint Luke’s Mid America Heart Institute, Kansas, MO, USA; 3Chaim Sheba Medical Center, The ...
McCarty MF, DiNicolantonio JJ, Lerner A
doaj  

Bronchospasm and its biophysical basis in airway smooth muscle

Respiratory Research, 2004
Airways hyperresponsiveness is a cardinal feature of asthma but remains unexplained. In asthma, the airway smooth muscle cell is the key end-effector of bronchospasm and acute airway narrowing, but in just the past five years our understanding of the ...
Fredberg Jeffrey J
doaj   +1 more source

Leukotriene C4-Synthesis Deficiency

Pediatric Neurology Briefs, 1998
A leukotriene C4-synthesis deficiency, a new inborn error of eicosanoid metabolism characterized by hypotonia, microcephaly, failure to thrive, and retarded development, is described in an infant who died aged 6 months after a rapidly progressive course ...
J Gordon Millichap
doaj   +1 more source

Serum IgE as a Biomarker of Severity and Short-term Treatment Response in Steroid-naïve Children with Asthma: A Hospital-based Prospective Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Paediatric asthma is a growing public health challenge in Low- and Middle-Income Countries (LMICs), with increasing prevalence and substantial morbidity.
Kishore Alagesan, Prasanna Raju, Vaishnavi Sivaji, Preethi Suresh, Padmanaban Srinivasan, Subash Sundar   +5 more
doaj   +1 more source

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways

Cells, 2023
Bronchodilators and anti-inflammatory agents are the mainstream treatments in chronic obstructive and pulmonary disease (COPD) and asthma.
Joseph Antony Jude, Ian Dainty, Nikhil Karmacharya, William Jester, Reynold Panettieri   +4 more
doaj   +1 more source

More Relaxation by Deep Breath on Methacholine- Than on Exercise-Induced bronchoconstriction during the Routine Testing of Asthmatic Children

Frontiers in Physiology, 2017
Deep inspiration (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation.
Iulia Ioan, Iulia Ioan, Aurélie Tatopoulos, Stéphanie Metche, Laurianne Coutier, Emmanuelle Houriez, Sébastien Kiefer, Aurore Blondé, Claude Bonabel, Claude Bonabel, François Marchal, François Marchal, Jocelyne Derelle, Cyril E. Schweitzer, Cyril E. Schweitzer, Cyril E. Schweitzer, Silvia Demoulin-Alexikova, Silvia Demoulin-Alexikova   +17 more
doaj   +1 more source