Results 41 to 50 of about 16,689 (169)

Nasal Airway Transcriptome Reflects Selected Asthma‐Associated Gene Signatures in the Lower Airways

Allergy, EarlyView.
Seven genes and two gene modules were consistently associated with asthma in both airway compartments in ARMS and were validated in ATLANTIS. The two modules reflected IL‐13 related inflammation and mast cell activity, respectively. Nasal gene signatures provide a non‐invasive proxy for selected bronchial asthma‐associated gene signatures. ARMS, Asthma
Hui Wen, Tessa Kole, Orestes A. Carpaij, Tatiana Karp, Victor Guryev, Alen Faiz, Kian Fan Chung, Pankaj Bhavsar, Ian M. Adcock, Salman Siddiqui, Andy Lan, Katie L. Raby, Nazanin Zounemat‐Kermani, Chris Brightling, Dave Singh, Janwillem Kocks, Monica Kraft, Bianca Beghé, Klaus F. Rabe, Alberto Papi, Machteld N. Hylkema, Martijn C. Nawijn, Maarten van den Berge   +22 more
wiley   +1 more source

Is Asthma Remission a New Achievable Goal? A Review of the Current Drug‐Related Evidence and Predictors

Allergy, EarlyView.
ABSTRACT Advances in asthma therapies have shown that clinical remission may be an achievable therapeutic goal for patients with asthma. This review discusses the current definitions of remission in asthma, the predictors of remission, airway inflammation/epithelial damage in asthma remission, airway remodeling, paradigms in defining remission and ...
Fatma Esra Gunaydin, Giulia Marcassa, Bianca Olivieri, Gianenrico Senna, Marco Caminati   +4 more
wiley   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Airway dysfunction in elite swimmers: prevalence, impact, and challenges

Open Access Journal of Sports Medicine, 2016
Mitch Lomax Department of Sport and Exercise Science, University of Portsmouth, Portsmouth, UK Abstract: The prevalence of airway dysfunction in elite swimmers is among the highest in elite athletes. The traditional view that swimmers naturally gravitate
Lomax M
doaj  

Therapeutic targeting of bleomycin‐induced pulmonary fibrosis by human bone marrow mesenchymal stem cell‐derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell‐derived extracellular vesicles (BM‐MSC‐EVs) with an IPF treatment, pirfenidone (PFD), in mature adult mice with established pulmonary ...
Jennie S. Charoenphannathon, Simon G. Royce, Yasmin Higham, Jane E. Bourke, Chrishan S. Samuel   +4 more
wiley   +1 more source

Effect of Inhaled Prostaglandin E2 on Methacholine and Leukotriene D4 Airway Responsiveness in Asthmatic Subjects

Canadian Respiratory Journal, 1996
Previous studies in asthmatics have demonstrated that the endogenous release of inhibitory prostaglandins limits the bronchoconstrictor response to repeated challenges with exercise and histamine, and that inhaled prostaglandin (PG) E2 attenuates ...
Wil Hm Stevens, Cheryl P VanderHeyden, Paul M O'Byrne   +2 more
doaj   +1 more source

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

Respiratory Research, 2006
Background It has been proposed that serotonin (5-HT)-mediated constriction of the murine trachea is largely dependent on acetylcholine (ACh) released from the epithelium.
Koepsell Hermann, Wess Jürgen, Schinkel Alfred H, Wessler Ignatz, Akinci Sibel, Wiegand Silke, Kummer Wolfgang, Haberberger Rainer V, Lips Katrin S   +8 more
doaj   +1 more source

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

Factors Associated with Poor Asthma Control among Sudanese Patients Attending Atbara Teaching Hospital in Sudan

Sudan Journal of Medical Sciences
Objective: To identify factors associated with poor bronchial asthma control in patients attending Atbara Teaching Hospital, Sudan, in 2020. Methods: This was an analytical, descriptive, cross-sectional hospital-based study conducted at the Atbara ...
Hadeel Kareem Aladdin, Sufian Khalid Mohammed Noor, Amro Mohamed Fagir Farah, Sara Elamin Bushara   +3 more
doaj   +1 more source

Broncoespasmo induzido por exercício em corredores brasileiros de longa distância de elite Exercise-induced bronchoconstriction in elite long-distance runners in Brazil

Jornal Brasileiro de Pneumologia, 2012
OBJETIVO: Determinar a prevalência de broncoespasmo induzido por exercício em corredores brasileiros de longa distância de elite e se há uma diferença na carga de treinamento entre atletas com e sem broncoespasmo induzido por exercício.
Renata Nakata Teixeira, Luzimar Raimundo Teixeira, Luiz Augusto Riani Costa, Milton Arruda Martins, Timothy Derick Mickleborough, Celso Ricardo Fernandes Carvalho   +5 more
doaj   +1 more source