Results 41 to 50 of about 23,197 (178)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

More Relaxation by Deep Breath on Methacholine- Than on Exercise-Induced bronchoconstriction during the Routine Testing of Asthmatic Children

Frontiers in Physiology, 2017
Deep inspiration (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation.
Iulia Ioan, Iulia Ioan, Aurélie Tatopoulos, Stéphanie Metche, Laurianne Coutier, Emmanuelle Houriez, Sébastien Kiefer, Aurore Blondé, Claude Bonabel, Claude Bonabel, François Marchal, François Marchal, Jocelyne Derelle, Cyril E. Schweitzer, Cyril E. Schweitzer, Cyril E. Schweitzer, Silvia Demoulin-Alexikova, Silvia Demoulin-Alexikova   +17 more
doaj   +1 more source

Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. [PDF]

PLoS ONE, 2013
Airway remodelling, including smooth muscle remodelling, is a primary cause of airflow limitation in asthma. Recent evidence links bronchoconstriction to airway remodelling in asthma. The mechanisms involved are poorly understood.
Tjitske A Oenema, Harm Maarsingh, Marieke Smit, Geny M M Groothuis, Herman Meurs, Reinoud Gosens   +5 more
doaj   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Expanding the Use of PAVA Spray in Young Offender Institutions: The King (on the application of The Howard League for Penal Reform) v The Secretary of State for Justice

The Modern Law Review, EarlyView.
This case note critically examines the January 2026 High Court judgment in The King (on the application of The Howard League for Penal Reform) v The Secretary of State for Justice which dismissed a judicial review challenging the expansion of the use of PAVA spray in Young Offender Institutions (YOIs) in England.
Raymond Arthur
wiley   +1 more source

Loss of bronchoprotection to Salbutamol during sputum induction with hypertonic saline: implications for asthma therapy

Allergy, Asthma & Clinical Immunology, 2018
Background Sputum induction with hypertonic saline in obstructive airway diseases is generally safe. However, saline induces bronchoconstriction in some patients despite pre-medication with Salbutamol. Our objectives were to investigate the predictors of
Hongyu Wang, Melanie Kjarsgaard, Terence Ho, John D. Brannan, Parameswaran Nair   +4 more
doaj   +1 more source

Ventilation defect formation in healthy and asthma subjects is determined by lung inflation. [PDF]

PLoS ONE, 2012
Imaging studies have demonstrated that ventilation during bronchoconstriction in subjects with asthma is patchy with large ventilation defective areas (Vdefs).
R Scott Harris, Hanae Fujii-Rios, Tilo Winkler, Guido Musch, Marcos F Vidal Melo, José G Venegas   +5 more
doaj   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Hypocapnia-induced bronchoconstriction [PDF]

, 1988
Hypocapnia-induced bronchoconstriction has been recognized for over J0 years, however, its nechanisms have to date renained essentially unknown. This thesis describes a guínea pig model of hypocapnia-induced bronchoconstriction and elucidates the ...
Reynolds, Ann Michelle
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