Results 31 to 40 of about 23,197 (178)

Bronchospasm and its biophysical basis in airway smooth muscle

Respiratory Research, 2004
Airways hyperresponsiveness is a cardinal feature of asthma but remains unexplained. In asthma, the airway smooth muscle cell is the key end-effector of bronchospasm and acute airway narrowing, but in just the past five years our understanding of the ...
Fredberg Jeffrey J
doaj   +1 more source

Leukotriene C4-Synthesis Deficiency

Pediatric Neurology Briefs, 1998
A leukotriene C4-synthesis deficiency, a new inborn error of eicosanoid metabolism characterized by hypotonia, microcephaly, failure to thrive, and retarded development, is described in an infant who died aged 6 months after a rapidly progressive course ...
J Gordon Millichap
doaj   +1 more source

The interaction between bronchoconstriction and cough in asthma [PDF]

, 2017
Variable airflow obstruction is a pathophysiological hallmark of asthma; however, the interactions between acute bronchoconstriction and the cough reflex are poorly understood.
Woodhead, Mark, Jaclyn A Smith, Badri, Huda; id_orcid, Paul M O'Byrne, O'Byrne, Paul M, Imran Satia, Mark Woodhead, Satia, Imran, Smith, Jaclyn A; id_orcid, Fowler, Stephen J; id_orcid, Huda Badri, Stephen J Fowler   +11 more
core   +1 more source

Serum IgE as a Biomarker of Severity and Short-term Treatment Response in Steroid-naïve Children with Asthma: A Hospital-based Prospective Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Paediatric asthma is a growing public health challenge in Low- and Middle-Income Countries (LMICs), with increasing prevalence and substantial morbidity.
Kishore Alagesan, Prasanna Raju, Vaishnavi Sivaji, Preethi Suresh, Padmanaban Srinivasan, Subash Sundar   +5 more
doaj   +1 more source

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways

Cells, 2023
Bronchodilators and anti-inflammatory agents are the mainstream treatments in chronic obstructive and pulmonary disease (COPD) and asthma.
Joseph Antony Jude, Ian Dainty, Nikhil Karmacharya, William Jester, Reynold Panettieri   +4 more
doaj   +1 more source

A study to assess the prevalence of exercise-induced bronchoconstriction in inter-county hurling [PDF]

, 2017
Exercise-Induced Bronchoconstriction (EIB) is an acute, transient airway narrowing occurring after exercise which may impact athletic performance. Studies report 10% of the general population and up to 90% of asthmatics experience EIB. Ninety-two players
Stack, M., Eustace, Joseph A., Greene, E., Murphy, B., Cronin, Owen, Murphy, C., Hunt, Eithne B., Bowen, Bernadette, Crowley, T., Hay, S., Ronan, Nicola J., Murphy, Desmond M., Hunt, Eithne, Plant, Barry J.   +13 more
core   +1 more source

Deep inspiration and the emergence of ventilation defects during bronchoconstriction: a computational study. [PDF]

PLoS ONE, 2014
Deep inspirations (DIs) have a dilatory effect on airway smooth muscle (ASM) that helps to prevent or reduce more severe bronchoconstriction in healthy individuals. However, this bronchodilation appears to fail in some asthmatic patients or under certain
Amir H Golnabi, R Scott Harris, Jose G Venegas, Tilo Winkler   +3 more
doaj   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Oscillometric assessment of bronchodilator response in horses with severe asthma during remission

Equine Veterinary Journal, EarlyView.
Abstract Background During clinical remission of severe equine asthma (SEA), affected animals can be challenging to distinguish from healthy horses. In humans, the degree of bronchodilation achieved with a β2‐adrenergic bronchodilator is helpful in differentiating asthmatics from healthy subjects.
Séléna de Wasseige, Sophie Mainguy‐Seers, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

Impact of Obesity on Lung Function in Cats with Bronchoconstriction

Veterinary Sciences, 2022
Obesity is a nutritional disorder commonly diagnosed in adult cats that has been associated with an increased risk of different chronic diseases including respiratory diseases.
Alicia Caro-Vadillo, J. Alberto Montoya-Alonso, Laín García-Guasch   +2 more
doaj   +1 more source