Results 51 to 60 of about 23,197 (178)

Mechanical properties of lung parenchyma during bronchoconstriction

, 1999
Interdependence between airways and the lung parenchyma is thought to be a major mechanism preventing excessive airway narrowing during bronchoconstriction.
Mitsushi Okazawa, Peter D. Paré, Yulia D’Yachkova   +2 more
core   +1 more source

Failed Mucosal Allostasis Distinguishes Murine IgG‐ From IgE‐Mediated Recurrent Severe Anaphylaxis

Allergy, EarlyView.
This study investigates IgE‐ and IgG‐mediated pathways in acute and recurrent anaphylaxis using a murine ASA‐PSA model, assessing barrier integrity, immune activation and tissue remodelling across pulmonary and intestinal compartments. Recurrent IgE‐ and IgG‐mediated anaphylaxis produces divergent mucosal outcomes despite comparable systemic severity ...
Abdurrahman Simsek, Muhammed Ali Kizmaz, Tugce Bozkurt, Sude Toprakkaz, Mehmet Emre Topcu, Musa Ozgur Ozyigit, Ahmet Akkoc, Dane Ediger, Ferah Budak Sener   +8 more
wiley   +1 more source

Airway dysfunction in elite swimmers: prevalence, impact, and challenges

Open Access Journal of Sports Medicine, 2016
Mitch Lomax Department of Sport and Exercise Science, University of Portsmouth, Portsmouth, UK Abstract: The prevalence of airway dysfunction in elite swimmers is among the highest in elite athletes. The traditional view that swimmers naturally gravitate
Lomax M
doaj  

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

Respiratory Research, 2006
Background It has been proposed that serotonin (5-HT)-mediated constriction of the murine trachea is largely dependent on acetylcholine (ACh) released from the epithelium.
Koepsell Hermann, Wess Jürgen, Schinkel Alfred H, Wessler Ignatz, Akinci Sibel, Wiegand Silke, Kummer Wolfgang, Haberberger Rainer V, Lips Katrin S   +8 more
doaj   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Effect of Inspiratory Muscle Training on Exercise Tolerance in Asthmatic Individuals [PDF]

, 2011
The aim of this study was to determine the effects of inspiratory muscle training (IMT) on exercise tolerance, inspiratory muscle fatigue, and the perception of dyspnea in asthmatic individuals. Using a matched double-blind placebo-controlled design, 15
Sandra Tecklenburg-Lund (239522), Louise A. Turner (7243841), Tecklenburg-Lund, S, Tecklenburg-Lund, Sandra, JOEL M. STAGER, Mickleborough, TD, Mcconnell, AK, LOUISE A. TURNER, Lindley, MR, ALISON K. MCCONNELL, Alison K. McConnell (7243844), Martin Lindley (1255941), Timothy D. Mickleborough (7239956), TIMOTHY DEREK MICKLEBOROUGH, Lindley, MR; id_orcid, SANDRA TECKLENBURG-LUND, Stager, JM, McConnell, Alison, Mickleborough, Timothy, Turner, LA, Stager, Joel, Lindley, Martin, Joel M. Stager (7239959), Turner, Louise, MARTIN R. LINDLEY   +24 more
core   +1 more source

Bronchoconstriction in nonhuman primates: a species comparison

, 2011
Bronchoconstriction is a characteristic symptom of various chronic obstructive respiratory diseases such as chronic obstructive pulmonary disease and asthma.
Mätz-Rensing, K., Lauenstein, H.-D., Fuchs, E., Zöller, M., Martin, C., Seehase, S., Winkler, C., Kaup, F. J., Schlumbohm, C., Switalla, S., Schlepütz, M.   +10 more
core   +3 more sources

Effect of Inhaled Prostaglandin E2 on Methacholine and Leukotriene D4 Airway Responsiveness in Asthmatic Subjects

Canadian Respiratory Journal, 1996
Previous studies in asthmatics have demonstrated that the endogenous release of inhibitory prostaglandins limits the bronchoconstrictor response to repeated challenges with exercise and histamine, and that inhaled prostaglandin (PG) E2 attenuates ...
Wil Hm Stevens, Cheryl P VanderHeyden, Paul M O'Byrne   +2 more
doaj   +1 more source

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

Clinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole, Ingrid Laing, Ryan Mead‐Hunter, Peter Le Souef, Guicheng Zhang   +4 more
wiley   +1 more source

Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways

Respiratory Research, 2023
Introduction The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß2-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocorticoids, long-acting ß2 ...
Paulina Hempel, Virag Klein, Anna Michely, Svenja Böll, Annette D. Rieg, Jan Spillner, Till Braunschweig, Saskia von Stillfried, Norbert Wagner, Christian Martin, Klaus Tenbrock, Eva Verjans   +11 more
doaj   +1 more source