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New Bronchodilator Joins Group of Environmentally Friendly Agents
DAMIAN MCNAMARA
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ChemInform Abstract: TRICYCLIC QUINUCLIDYLIDENES AS POTENTIAL ANTIHISTAMINE‐BRONCHODILATING AGENTS
Chemischer Informationsdienst, 1975AbstractAus den Oxo‐Verbindungen (I) erhält man mit 3‐Chlorchinuclidin (II) in Gegenwart von Na die Carbinole (III), aus (IV) erhält man über das Li‐Derivat mit 3‐Chinuclidon (V) die Carbinole (VI).
F. J. Villani+2 more
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Efficacy of bronchodilator therapy in bronchiolitis. A meta-analysis.
Archives of Pediatrics & Adolescent Medicine, 1996OBJECTIVE To determine if bronchodilators are efficacious in treating bronchiolitis. DATA SOURCES A search of bibliographic databases (MEDLINE, Excerpta Medica, and Reference Update) for bronchiolitis and albuterol or ipratropium bromide, or adrenergic
J. Kellner+3 more
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LG 30435 is a new bronchodilator agent with multiple sites of action
European Journal of Pharmacology, 1986LG 30435, a new quaternary derivative of the H1-histamine antagonist mequitazine, was evaluated against bronchospasm induced by different agonists. This compound inhibited equipotently methacholine- and histamine-induced contractions of isolated guinea-pig trachea. When administered to guinea-pig by the i.v. and/or the aerosol route, LG 30435 inhibited
Marco Criscuoli+2 more
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Anticholinergic, antimuscarinic bronchodilators.
American Review of Respiratory Disease, 2015The anticholinergic, antimuscarinic compounds are potent and hitherto neglected bronchodilators. Although atropine itself has drawbacks, principally related to its rapid absorption and consequent systemic side effects, its quaternary ammonium congeners ...
N. Gross, M. Skorodin
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Journal of Medicinal Chemistry, 1975
The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the ...
F J, Villani+11 more
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The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the ...
F J, Villani+11 more
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The variable effect of a bronchodilating agent on pulmonary function in cystic fibrosis
The Journal of Pediatrics, 1973Nine of 50 patients with cystic fibrosis were found to have a measurable response to bronchodilators. The maximum expiratory flow-volume curve was the most sensitive test for detecting it. Of these nine patients, five improved and could be considered to have an associated asthmatic diathesis.
L.I. Landau, P.D. Phelan
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Chest, 2004
STUDY OBJECTIVES The management of stable patients with COPD depends on the severity of symptoms and airflow limitation. Regarding inflammation, corticosteroids are the only medications that are recommended for use, and only under restricted ...
D. Perng+4 more
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STUDY OBJECTIVES The management of stable patients with COPD depends on the severity of symptoms and airflow limitation. Regarding inflammation, corticosteroids are the only medications that are recommended for use, and only under restricted ...
D. Perng+4 more
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Bronchodilator effect of inhaled formoterol vs salbutamol over 12 hours.
Chest, 1990The bronchodilator effects were compared in 16 stable asthma patients for 12 hours after either 12 micrograms formoterol or 200 micrograms salbutamol from a metered-dose aerosol in a randomized, double-blind, crossover study.
Francis P.V. Maesen+3 more
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Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD.
Drugs of Today, 2002Tiotropium bromide (Spiriva, BA679BR, Boehringer Ingelheim) is a novel inhaled, long-acting anticholinergic bronchodilator that is employed as a once-daily maintenance treatment for patients with chronic obstructive pulmonary disease (COPD).
T. Hansel, P. Barnes
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