Results 231 to 240 of about 325,007 (302)

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Cross-Talk Between Signaling and Transcriptional Networks Regulating Thermogenesis-Insights into Canonical and Non-Canonical Regulatory Pathways. [PDF]

Int J Mol Sci
Simka-Lampa K.
europepmc   +1 more source

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, EarlyView.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source

Antioxidant Activity of Maillard Reaction Products and Consumer Acceptance of Nurungji Fortified with Sorghum (<i>Sorghum bicolor</i> L.). [PDF]

Foods
Wee WJ, Kwak EJ, Choi IS.
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

ROS-mediated membrane damage and antioxidant imbalance drive apple flesh browning during cold storage. [PDF]

Front Plant Sci
Wang J, Li F, Li B, Li L, Shang J, Fu X, Zhao X, Li X, Zhang X, Ahmed ZFR.   +9 more
europepmc   +1 more source

Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment. [PDF]

Bioact Mater
Zhang S, Fan R, Chen H, Gong H, Mu M, Han B, Guo G.   +6 more
europepmc   +1 more source

From selection signatures in cattle to functional validation in mice: HSPA12B negatively regulates adipose browning and thermogenesis. [PDF]

J Anim Sci
Gao Y, Wang J, Jiang Q, Wang X, Ju Z, Yang C, Wei X, Zhang Y, Xiao Y, Huang J.   +9 more
europepmc   +1 more source