Results 21 to 30 of about 3,794 (217)

Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice.

PLoS ONE, 2008
The purpose of this study was to determine whether mice exposed to chronic cigarette smoke develop features of early age-related macular degeneration (AMD).
Masashi Fujihara, Norihiro Nagai, Thomas E Sussan, Shyam Biswal, James T Handa   +4 more
doaj   +1 more source

Design, development and characterization of synthetic Bruch’s membranes [PDF]

Acta Biomaterialia, 2017
Age-related macular degeneration (AMD) is a leading cause of blindness, and dry AMD has no effective treatment. Retinal constructs comprising retinal pigment epithelium (RPE) cells supported by electrospun scaffolds have been investigated to treat dry AMD.
Surrao, Denver C., Greferath, Ursula, Chau, Yu-Qian, Skabo, Stuart J., Huynh, Mario, Shelat, Kinnari J., Limnios, Ioannis J., Fletcher, Erica L., Liu, Qin   +8 more
openaire   +4 more sources

Horizontal and vertical optic disc rotation. The Beijing Eye Study.

PLoS ONE, 2017
PurposeTo measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters.DesignPopulation-based study.MethodsIn the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 ...
Yuan Yuan Fan, Jost B Jonas, Ya Xing Wang, Chang Xi Chen, Wen Bin Wei   +4 more
doaj   +1 more source

Molecular Mechanisms of Druze Formation in the Retina in Age-Related Macular Degeneration

Oftalʹmologiâ, 2020
Age-related macular degeneration is the main cause of vision loss in aged people. A significant risk factor of disease is considered dysfunction of retinal pigment epithelium, which is accompanied by accumulation of lipids in Bruch membrane as drusen or ...
E. F. Barinov
doaj   +1 more source

Corrugated Bruch′s membrane in high myopia [PDF]

Acta Ophthalmologica, 2017
AbstractPurposeTo assess the appearance of Bruch′s membrane (BM) in axially elongated eyes.MethodsThe light‐microscopical investigation included histological anterior–posterior sections of human eyes. Using a light microscope, we assessed whether BM in the posterior segment was straight or locally corrugated.
Jost B. Jonas, Rahul A. Jonas, Kyoko Ohno‐Matsui, Leonard Holbach, Songhomitra Panda‐Jonas   +4 more
openaire   +2 more sources

Efficacy of Ethanol Extract of Fructus lycii and Its Constituents Lutein/Zeaxanthin in Protecting Retinal Pigment Epithelium Cells against Oxidative Stress: In Vivo and In Vitro Models of Age-Related Macular Degeneration

Journal of Ophthalmology, 2013
Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Oxidative stress plays a large role in the pathogenesis of AMD. The present study was to evaluate the effects of Fructus lycii ethanol extract on AMD in mice and to ...
Xinrong Xu, Li Hang, Binglin Huang, Yuanhua Wei, Shizhong Zheng, Wei Li   +5 more
doaj   +1 more source

PERIPAPILLARY ATROPHY WITH LARGE DEHISCENCES IN BRUCH MEMBRANE IN PSEUDOXANTHOMA ELASTICUM

, 2015
PURPOSE: To describe a new set of findings in eyes with pseudoxanthoma elasticum, specifically large defects in Bruch membrane. METHODS: Retrospective review of the optical coherence tomography image obtained with the Heidelberg Spectralis of the ...
Spaide, R. F., Jonas, J. B.
core   +1 more source

Prototyping a Versatile Two-Layer Multi-Channel Microfluidic Device for Direct-Contact Cell-Vessel Co-Culture

Micromachines, 2020
Microfluidic devices are gaining increasing popularity due to their wide applications in various research areas. Herein, we propose a two-layer multi-channel microfluidic device allowing for direct-contact cell-vessel co-culture.
Li-Jiun Chen, Bibek Raut, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji   +4 more
doaj   +1 more source

Stries angioïdes compliquées d'une néovascularisation choroïdienne

The Pan African Medical Journal, 2014
Les stries angioïdes sont des lésions rares du fond d'oeil. Elles sont souvent associées à des pathologies générales telles le pseudoxanthome élastique, la drépanocytose, la maladie de Paget ou le syndrome de Ehlers Danlos.
Mohammed El Mellaoui, Abdelkader Laktaoui   +1 more
doaj   +1 more source

Scattergram showing the distribution of the macular Bruch´s membrane length (distance between the fovea and the temporal edge of the papillary Bruch´s membrane opening) in relationship to axial length.

, 2015
Scattergram showing the distribution of the macular Bruch´s membrane length (distance between the fovea and the temporal edge of the papillary Bruch´s membrane opening) in relationship to axial length.
Ya Xing Wang (310734), Yi Liu (36759), Liang Xu (102656), Wen Bin Wei (395180), Jost B. Jonas (291825), Qi Zhang (28502)   +5 more
core   +1 more source