Results 51 to 60 of about 3,794 (217)

Research status of clinicopathologic studies of polypoidal choroidal vasculopathy

Yanke Xuebao
Polypoidal choroidal vasculopathy (PCV) is the main subtype of neovascular age-related macular degeneration (AMD)in China. PCV differs from typical neovascular AMD in terms of epidemiology, clinical presentation, imaging features, and natural disease ...
LI Miaoling, WEN Feng
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, Volume 16, Issue 6, Page 1150-1165, June 2026.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Decoding the Factor H‐Related Proteins: Gatekeepers of Complement Dysregulation in AMD

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review will explore the role of the factor H‐related (FHR) proteins in age‐related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world ...
Jiaqi Tang, Nathalie Zgoda, Simon J. Clark   +2 more
wiley   +1 more source

Autologous Transplantation of Retinal Pigment Epithelium-Bruch's Membrane Complex for Hemorrhagic Age-Related Macular Degeneration

, 2009
PURPOSE. To evaluate a surgical procedure for patients with hemorrhagic age-related macular degeneration (AMD). METHODS. This procedure consisted of excision of the choroidal neovascular membrane and transplantation of autologous retinal pigment ...
Yuntao Hu, Dou, Hongliang, Changguan Wang, Xu, Yimin, Zhengqin Yin, Yuling Liu, Liang Han, Yimin Xu, Ma, Zhizhong, Wang, Zhiqiang, Zhiqiang Wang, Han, Liang, Wang, Changguan, Liu, Yuling, Zhizhong Ma, Xuefeng Feng, Feng, Xuefeng, Hu, Yuntao, Yin, Zhengqin, Hongliang Dou   +19 more
core   +1 more source

Pilot satellitome analysis of the model plant, Physcomitrella patens, revealed a transcribed and high-copy IGS related tandem repeat [PDF]

Comparative Cytogenetics, 2018
Satellite DNA (satDNA) constitutes a substantial part of eukaryotic genomes. In the last decade, it has been shown that satDNA is not an inert part of the genome and its function extends beyond the nuclear membrane.
Ilya Kirov, Marina Gilyok, Andrey Knyazev, Igor Fesenko   +3 more
doaj   +2 more sources

Oxidative Stress and Lipid Accumulation Augments Cell Death in LDLR-Deficient RPE Cells and Ldlr^−/− Mice

Cells, 2022
Lipid peroxidation from oxidative stress is considered a major contributor to age-related macular degeneration (AMD). The retina is abundant with circulating low-density lipoproteins (LDL), which are taken up by LDL receptor (LDLR) in the RPE and Müller ...
Parameswaran Gangadharan Sreekumar, Feng Su, Christine Spee, Eduardo Araujo, Steven Nusinowitz, Srinivasa T Reddy, Ram Kannan   +6 more
doaj   +1 more source

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration

, 2023
The complement system is crucial for immune surveillance, providing the body’s first line of defence against pathogens. However, an imbalance in its regulators can lead to inappropriate overactivation, resulting in diseases such as age-related ...
Mariantonia Ferrara, Majlinda Lako, Katharina Lo, Ingrid Porpino Meschede, Sarah Hammadi, Claire Harris, Nikolaos Tzoumas, David H. Steel   +7 more
core   +1 more source

LES STRIES ANGIOÏDES : A PROPOS DE 10 CAS

Journal de la Société Marocaine d’Ophtalmologie, 2015
Les stries angioïdes correspondent à des lignes de rupture localisées de la membrane de Bruch, habituellement asymptomatiques, ces stries peuvent se néovasculariser et entraîner un syndrome maculaire avec baisse marquée de l’acuité visuelle.
F Alami, N El Berdaoui, A Boulanouar, Z Hajji, A Berraho   +4 more
doaj   +1 more source

Bruch’s Membrane Opening Minimum Rim Width Measurement with SD-OCT: A Method to Correct for the Opening Size of Bruch’s Membrane [PDF]

Journal of Ophthalmology, 2017
A precise evaluation of the retinal nerve fiber layer thickness (RNFLT) is key for diagnosing and monitoring glaucoma. The Bruch’s membrane opening minimum rim width (BMO-MRW) has been proposed as a reproducible assessment of the optic nerve. The BMO-MRW measures the minimum distance from the BMO to the internal limiting membrane.
Robert Kromer, Martin Stephan Spitzer
openaire   +3 more sources