Bruton’s Tyrosine Kinase Inhibition for the Treatment of Rheumatoid Arthritis
ImmunoTargets and Therapy, 2021 Laura C Arneson,1,* Kristen J Carroll,1,* Eric M Ruderman2 1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; 2Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School ...
Arneson LC, Carroll KJ, Ruderman EM
doaj
DNA methyltransferase inhibitors in hematological malignancies and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger +3 more
wiley +1 more source
Profound Sinoatrial Arrest Associated with Ibrutinib
Case Reports in Oncological Medicine, 2017 Background. Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for second-line treatment for mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and Waldenström macroglobulinemia.
Kanupriya Mathur +3 more
doaj +1 more source
Regulatory Mechanism of PTP-PEST for IgE Fc Receptor Signaling [PDF]
, 2010 連続したくしゃみ、止まらない鼻水などやっかいな症状で悪名の高い所謂「アレルギー」を直接引き起こす細胞は、マスト細胞もしくは好塩基球である。マスト細胞は、IgE 受容体 (FcεR) を介して活性化され、顆粒中に蓄えた炎症物質放出と炎症性サイトカインの合成・放出によりアレルギー性炎症を惹起する。この細胞内シグナル伝達において、種々のタンパク質中のチロシンリン酸化と脱リン酸化制御が重要な働きをしている。我々は、以前、マスト細胞のFcεRシグナルにおける各種チロシン脱リン酸化酵素(PTP ...
片桐 達雄, 鈴木 望美
core +1 more source
Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. [PDF]
, 1998 We investigated the role of Bruton's tyrosine kinase (Btk) in FcepsilonRI-dependent activation of mouse mast cells, using xid and btk null mutant mice.
Alt, FW +16 more
core
Génexpressziós profil vizsgálata a pajzsmirigy hámeredetű tumoraiban = Gene-expression profiles in the thyroid tumors of epithelial origin [PDF]
, 2007 A thyroid tumorok kialakulása az epitelialis carcinogenezis többlépcsős modelljeként irható le. Tumor szuppresszor gének, és az onkogének három fő csoportjába tartozó gének (GTP-kötő protein, sejtmagi transzkripciós faktor, tirozin kináz) mutációinak ...
Ember, István +2 more
core
Isoform of Bruton's tyrosine kinase (BTK) protein
, 2008 The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR ...
LAVITRANO, MARIALUISA +2 more
openaire +2 more sources
Novel Bruton's tyrosine kinase inhibitors currently in development.
OncoTargets and therapy, 2013 Bruton's tyrosine kinase (Btk) is intimately involved in multiple signal-transduction pathways regulating survival, activation, proliferation, and differentiation of B-lineage lymphoid cells. Btk is overexpressed and constitutively active in several B-lineage lymphoid malignancies.
D’Cruz, Osmond J, Uckun, Fatih M
openaire +2 more sources
Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL) [PDF]
, 2017 Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in the western world and remains incurable. It is driven by as yet unknown (auto)antigens via the B cell receptor (BCR) and growth, survival and expansion signals it receives from the ...
Rajakaruna, A., Rajakaruna, A.
core
Division of Analysis of Homeostasis [PDF]
, 2007 この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
永井 博弌
core +1 more source