Results 131 to 140 of about 178,517 (322)

Management of cardiovascular complications of bruton tyrosine kinase inhibitors [PDF]

British Journal of Haematology, 2021
Gregory Y.H. Lip, Gregory Y.H. Lip, Peter Hillmen, Piers E.M. Patten, Nilima Parry-Jones, Chloe Pek Sang Tang, Nicolas Martinez-Calle, Terry McCormack, Sunil Iyengar, Anna Schuh, Renata Walewska, Alexander R. Lyon   +11 more
openaire   +6 more sources

Endotypes in Immune Mediated Drug Reactions: Present and Future of Relevant Biomarkers. An EAACI Task Force Report

Allergy, EarlyView.
ABSTRACT Drug‐induced immune reactions are an important burden for patients and health systems. They can be classified into immediate‐drug hypersensitivity reactions (IDHRs) and delayed‐DHRs (DDHRs) based on their phenotype. Drugs do not always behave as allergens and need to bind to proteins, forming adducts.
C. Mayorga, R. Fernandez‐Santamaria, G. E. Çelik, M. Labella, G. Murdaca, M. Sokolowska, D. Naisbitt, V. Sabato   +7 more
wiley   +1 more source

PBMC-derived integration-free iPSCs line SDQLCHi039-A from a patient with X-linked agammaglobulinemia carrying a novel 9-bp in-frame deletion in BTK gene

Stem Cell Research, 2021
X-linked agammaglobulinemia (XLA, OMIM #300755) is one of the most common pediatric primary immunodeficiencies characterized by failure to produce mature B lymphocytes and hypogammaglobulinemia, caused by mutation of the gene encoding Bruton's tyrosine ...
Ning Liu, Xiaomeng Yang, Sulan Wang, Rui Dong, Yue Li, Yuqiang Lv, Yi Liu, Zhongtao Gai   +7 more
doaj  

Btk inhibition treats TLR7/IFN driven murine lupus. [PDF]

, 2016
Bruton's tyrosine kinase (Btk) is expressed in a variety of immune cells and previous work has demonstrated that blocking Btk is a promising strategy for treating autoimmune diseases.
Albertina Pereira, Andrew T Bender, Daigen Xu, Eileen Samy, Federica Morandi, Hui Tian, Jared Head, Kai Fu, Lesley Liu-Bujalski, Melinda Genest, Richard Caldwell, Roland Grenningloh, Shinji L Okitsu, Ursula Koehler, Yi-Ying Chen, Yin Wu   +15 more
core   +1 more source

Bruton's Tyrosine Kinase is involved in innate and adaptive immunity.

Histology and histopathology, 2005
Btk is a cytoplasmic tyrosine kinase, which is mainly involved in B cell receptor signalling. Gene targeting experiments revealed that Btk is important for B cell development and function. However, Btk is not only expressed in B cells, but also in most other haematopoietic lineages except for T cells and plasma cells.
Brunner, C., Müller, B., Wirth, T.
openaire   +4 more sources

Basophil Activation Test: Bridging Allergy and Oncology for Diagnostic, Therapeutic and Prognostic Applications in AllergoOncology: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT The basophil activation test (BAT) is gaining increasing relevance as an ex vivo functional assay in allergy to evaluate IgE‐mediated hypersensitivity reactions to food allergens, venoms, and drugs and to monitor tolerance induction. Establishing universal standard operating protocols has been difficult, due to several challenges including ...
Mariona Pascal, Jitesh Chauhan, Edward Knol, Rodolfo Bianchini, Mariana Castells, Leticia De las Vecillas, Karin Hartmann, Elena Izquierdo, Uta Jappe, Teodorikez‐Wilfox Jimenez‐Rodriguez, Francesca Levi‐Schaffer, Cristobalina Mayorga, Aurélie Poli, Frank Redegeld, Alexandra F. Santos, Erika Jensen‐Jarolim, Christoph Bergmann, Sophia N. Karagiannis, Heather J. Bax   +18 more
wiley   +1 more source

Streamlining SuFEx Inhibitor Development: A Unified Approach Using Photolabile and Orthogonal Sulfinate Protecting Groups

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
This Study outlines the discovery and selection of sulfinate protecting groups (SPGs) based on their overall stability, ease of synthesis, and simple deprotection conditions, including two novel, photolabile SPGs that can be directly converted to the sulfonyl fluoride (SFs) using light and selectfluor.
Twinkle I. Patel, Makayla L. Williams, Yumeng Chi, Ramkrishna Laha, Matthew J. Moschitto   +4 more
wiley   +2 more sources

Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes

Stem Cell Reports, 2019
Summary: Ibrutinib (IB) is an oral Bruton's tyrosine kinase (BTK) inhibitor that has demonstrated benefit in B cell cancers, but is associated with a dramatic increase in atrial fibrillation (AF).
Sanam Shafaattalab, Eric Lin, Effimia Christidi, Haojun Huang, Yulia Nartiss, Analucia Garcia, Jeehon Lee, Stephanie Protze, Gordon Keller, Liam Brunham, Glen F. Tibbits, Zachary Laksman   +11 more
doaj  

Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice.

PLoS ONE, 2014
The commensal yeast Candida albicans is part of the human intestinal microflora and is considered a "pathobiont", a resident microbe with pathogenic potential yet harmless under normal conditions. The aim of this study was to investigate the effect of C.
Karin Strijbis, Omer H Yilmaz, Stephanie K Dougan, Alexandre Esteban, Andrea Gröne, Carol A Kumamoto, Hidde L Ploegh   +6 more
doaj   +1 more source

The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL) [PDF]

, 2019
Chronic lymphocytic leukaemia (CLL) is characterised by a progressive accumulation of mature CD5+CD20+CD23+ lymphocytes. Despite the remarkable progress in our understanding of the immunobiology of CLL, the aetiology of the disease remains unknown.
Sayed, U., Sayed, U.
core