Results 161 to 170 of about 178,517 (322)

A Case Series and Literature Review on Zanubrutinib Therapy for the Treatment of Relapsed/Refractory Immune Thrombocytopenia

Cancer Reports
Background Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterised by low platelet count. Treatment discontinuation or heterogeneity in the pathogenesis of ITP heightens the occurrence of relapsed or refractory ITP.
Bingjie Ding, Mengjuan Li, Liu Liu, Xuewen Song, Yuanyuan Zhang, Ao Xia, Jingyuan Liu, Hu Zhou   +7 more
doaj   +1 more source

Assessment of ethnic differences in pharmacokinetics and clinical responses of acalabrutinib between Chinese and White patients with B‐cell malignancies

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2008-2019, July 2025.
Abstract Aims The aim of this study was to assess differences between Chinese and White patients in pharmacokinetics (PK) of, and clinical response to, acalabrutinib and its pharmacologically active major metabolite, ACP‐5862, to support recommended dosing in Chinese patients with B‐cell malignancies.
Tingting Yao, Junjie Ding, Shringi Sharma, Yunfei Li, Qianwei Xu, Peiming Ma   +5 more
wiley   +1 more source

Phagocytosis‐dependent activation of a TLR9–BTK–calcineurin–NFAT pathway co‐ordinates innate immunity to Aspergillus fumigatus

EMBO Molecular Medicine, 2015
Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection.
Susanne Herbst, Anand Shah, Maria Mazon Moya, Vanessa Marzola, Barbara Jensen, Anna Reed, Mark A Birrell, Shinobu Saijo, Serge Mostowy, Sunil Shaunak, Darius Armstrong‐James   +10 more
doaj   +1 more source

Genetic Subtype‐Based International Prognostic Index Prognostic Model in Diffuse Large B‐Cell Lymphoma

MedComm, Volume 6, Issue 7, July 2025.
1. Genetic subtypes based on molecular subtyping correlated with prognosis in DLBCL. 2. Integrated genetic subtype‐based IPI model revealed prognostic discrimination. 3. New four‐category risk model defined for integrated model showed diverse prognosis.
Lan Mi, Jili Deng, Jiayue Qin, Chen Zhang, Lixia Liu, Shunli Yang, Libin Chen, Hua‐Jun Wu, Haojie Wang, Jun Zhu, Hong Chen, Feng Lou, Shanbo Cao, Yuqin Song, Weiping Liu   +14 more
wiley   +1 more source

Trypanosoma cruzi trans-sialidase potentiates T cell activation through antigen-presenting cells: role of IL-6 and Bruton's tyrosine kinase [PDF]

, 2001
Wenda Gao, Miercio A. Pereira
openalex   +1 more source

Advancing Design Strategy of PROTACs for Cancer Therapy

MedComm, Volume 6, Issue 7, July 2025.
A comprehensive update on the PROTAC design, and highlighting the role of artificial intelligence in the PROTAC design for cancer therapy. ABSTRACT Proteolysis targeting chimeras (PROTACs) have emerged as a groundbreaking class of anticancer therapeutics.
Hang Luo, Yuan Tian, Razack Abdullah, Baoting Zhang, Yuan Ma, Ge Zhang   +5 more
wiley   +1 more source

Role of the PHTH Module in Protein Substrate Recognition by Bruton's Agammaglobulinemia Tyrosine Kinase [PDF]

, 2001
William E. Lowry, Jianyun Huang, Ming Lei, David J. Rawlings, Xin‐Yun Huang   +4 more
openalex   +1 more source

Distinct Cytokine Profiles in Chronic Spontaneous Urticaria Refractory to H1‐Antihistamines Compared to Healthy Controls

Clinical &Experimental Allergy, EarlyView.
Young‐Min Ye, Hyun‐Young Lee, Da‐Hye Moon, Kun‐Woo Park, Se‐Min Park   +4 more
wiley   +1 more source

Treatment Landscape in Pediatric Immune Thrombocytopenia: Addressing Unmet Needs

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Pediatric immune thrombocytopenia (ITP) is associated with a multifaceted burden on children and their parents/caregivers due to bleeding, fatigue, activity restrictions, and psychological distress. Most children recover within 12 months, but up to 30% develop chronic ITP.
Joana Azevedo, Jennifer DiRaimo, Cindy Neunert, Nichola Cooper, Rachael F. Grace   +4 more
wiley   +1 more source

The role of miRNA-4516 in regulating Bruton's tyrosine kinase expression and colorectal cancer progression in a sample of Iraqi population

Journal of Biological Research
Considering the second-highest global death rate, Colorectal Cancer (CRC) is the second most prevalent form of cancer in women and the third most frequent cancer type in men.
Ahmed Sadoon Hassain, Hiba Muneer Abdel Hassan Al-Khafaji, Maryam Qasim Mohammed   +2 more
doaj   +1 more source