Results 291 to 300 of about 178,517 (322)

Phosphorylation of Bruton’s tyrosine kinase by c-Abl

Biochemical and Biophysical Research Communications, 2002
Bruton's tyrosine kinase (Btk) is necessary for B-lymphocyte development. Mutation in the gene coding for Btk causes X-linked agammaglobulinemia (XLA) in humans. Similar to Btk, c-Abl is a tyrosine kinase shuttling between the cytoplasm and the nucleus where it is involved in different functions depending on the localization. In this report we describe
Carl-Magnus Bäckesjö, Giulio Superti-Furga, Leonardo Vargas, C. I. Edvard Smith   +3 more
openaire   +3 more sources

Inhibition of Bruton´s tyrosine kinase as a novel therapeutic approach in multiple sclerosis

Expert Opinion on Investigational Drugs, 2020
Introduction B cells have increasingly come under the spotlight as mediators of inflammatory central nervous system (CNS) demyelinating diseases such as multiple sclerosis (MS).
Sebastian Torke, Martin S. Weber
semanticscholar   +1 more source

X-Linked Agammaglobulinemia and Bruton’s Tyrosine Kinase

1994
The genetic defect associated with human X-linked agammaglobulinemia (XLA) and murine X-linked immunodeficiency (XID) was recently identified as the deficiency of function of a new cytoplasmic tyrosine kinase called Bruton’s tyrosine kinase (Btk)1,2,3,4. The phenotypes associated with these immunodeficiencies indicate that Btk plays a crucial role in B
Satoshi Tsukada, Owen N. Witte
openaire   +3 more sources

Clinical Potential of Targeting Bruton's Tyrosine Kinase

International Reviews of Immunology, 2008
Targeting Bruton's tyrosine kinase (BTK) with a small-molecule inhibitor may be useful in treatment of BTK-expressing malignancies because of the antiapoptotic function of BTK in cancer cells. Furthermore, BTK inhibitors also exhibit antithrombotic properties, which may be desirable in the context of the increased risk of thromboembolic complications ...
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Bruton tyrosine kinase gene mutations in Argentina

Human Mutation, 2003
The block in differentiation from pro-B to pre-B cells results in a selective defect in the humoral immune response characteristic of human X-linked agammaglobulinemia (XLA). Mutations of Bruton tyrosine kinase (BTK) gene have been identified as the cause of XLA.
Matías Oleastro, Guillermina Feldman, Sergio D. Rosenzweig, Marta Zelazko, Jazmin El-Hakeh, Guillermo Basílico, Eva Maria Rivas, Liliana Berozdnik, Vera Giraudi, Angela Magnolia Rios Gallardo, Diana Liberatore, Miguel Galicchio, Silvia Danielian   +12 more
openaire   +3 more sources

The Role of Bruton's Tyrosine Kinase in Immune Cell Signaling and Systemic Autoimmunity.

Critical Reviews in Immunology, 2018
Bruton's tyrosine kinase (BTK) is an intracellular signaling molecule first identified as the molecule affected in X-linked agammaglobulinemia (XLA) patients, who almost completely lack peripheral B cells and serum immunoglobulins.
J. Rip, E. K. van der Ploeg, R. Hendriks, O. Corneth   +3 more
semanticscholar   +1 more source

Bruton's tyrosine kinase as a drug discovery target

Drug News & Perspectives, 2008
Bruton's tyrosine kinase (Btk) is an important mediator in multiple signal transduction pathways. Fifteen years of research have revealed a complex role for Btk in hematopoietic cells. These studies suggest that Btk may be a promising target for therapeutic intervention for several complicated diseases.
openaire   +2 more sources

Mutations in Bruton’s tyrosine kinase impair IgA responses

International Journal of Hematology, 2015
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by mutations in Bruton's tyrosine kinase (BTK), and is characterized by markedly decreased numbers of blood B cells and an absence of all immunoglobulin isotypes. We performed whole exome sequencing in a male pediatric patient with dysgammaglobulinemia with IgA deficiency.
Christina Grosserichter-Wagener, Noriko Mitsuiki, Yoshiyuki Kosaka, Menno C. van Zelm, Xi Yang, Hirokazu Kanegane, Kohsuke Imai, Hidetoshi Takada, Mirjam van der Burg, Tomohiro Morio, Sophinus J. W. Bartol, Shuki Mizutani, Osamu Ohara   +12 more
openaire   +3 more sources

Stability and folding of the SH3 domain of bruton's tyrosine kinase

Proteins: Structure, Function, and Genetics, 1996
Bruton's tyrosine kinase (BTK) plays an important role in B cell development. Deletion of C-terminal 14 amino acids of the SH3 domain of BTK results in X-linked agammaglobulinemia (XLA), an inherited disease. We report here on the stability and folding of SH3 domain of BTK.
Jya-Wei Cheng, Himatkumar V. Patel, Ya-Juan Chen, Ping-Chiang Lyu, Shiou-Ru Tzeng, Shih-Chieh Lin   +5 more
openaire   +3 more sources

The many faces of Bruton's tyrosine kinase [PDF]

Nature Biotechnology, 2012
openaire   +2 more sources