Results 41 to 50 of about 7,490 (233)
Dermatological Toxicities of Bruton’s Tyrosine Kinase Inhibitors
American Journal of Clinical Dermatology, 2020 The development of Bruton's tyrosine kinase (BTK) inhibitors represents a major breakthrough in the treatment of chronic lymphocytic leukemia and other B cell malignancies. The first-generation inhibitor ibrutinib works by covalent irreversible binding to BTK, a non-receptor tyrosine kinase of the TEC (transient erythroblastopenia of childhood) family ...
Sibaud, Vincent +5 more
openaire +2 more sources
Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase [PDF]
Molecular and Cellular Biology, 1995 Bruton's tyrosine kinase (Btk) is tyrosine phosphorylated and enzymatically activated following ligation of the B-cell antigen receptor. These events are temporally regulated, and Btk activation follows that of various members of the Src family of protein tyrosine kinases, thus raising the possibility that Src kinases participate in the Btk activation ...
S, Mahajan +5 more
openaire +2 more sources
Haematologica, 2019 Tyrosine kinases have been implicated in promoting tumorigenesis of several human cancers. Exploiting these vulnerabilities has been shown to be an effective anti-tumor strategy as demonstrated for example by the Bruton's tyrosine kinase (BTK) inhibitor,
Debora Soncini +24 more
doaj +1 more source
A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation [PDF]
, 2016 20siBruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells.
Bonin, S +19 more
core +1 more source
Nature Communications, 2020 PROTACs have emerged as promising therapeutic agents but their cellular uptake is often inefficient. Here, the authors show that reversible covalent warhead chemistry improves PROTAC intracellular accumulation and target engagement, and develop a dual ...
Wen-Hao Guo +18 more
doaj +1 more source
A distinct role for B1b lymphocytes in T cell-independent immunity [PDF]
, 2008 Pathogenesis of infectious disease is not only determined by the virulence of the microbe but also by the immune status of the host. Vaccination is the most effective means to control infectious diseases.
A Faili +123 more
core +2 more sources
Bruton's tyrosine kinase: oncotarget in myeloma
Oncotarget, 2012 Our findings therefore provide a strong rationale for investigating Btk inhibitors in MM and WM to target both tumor cells and their supporting BM microenvironment and thereby both suppress tumor cell growth and abrogate MM-induced bone disease.
Yu-Tzu, Tai, Kenneth C, Anderson
openaire +3 more sources
Turkish Journal of Hematology, 2021 Objective: This study aimed to retrospectively evaluate the efficacy, safety, and survival outcome of single-agent ibrutinib therapy in chronic lymphocytic leukemia patients. Materials and Methods: A total of 136 patients (mean age +- standard deviation:
Anıl Tombak +44 more
doaj +1 more source
Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib
Case Reports in Infectious Diseases, 2016 Cryptococcus is a unique environmental fungus that can cause disease most often in immunocompromised individuals with defective cell-mediated immunity. Chronic lymphocytic leukemia (CLL) is not known to be a risk factor for cryptococcal disease although ...
Koh Okamoto +2 more
doaj +1 more source
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells [PDF]
, 2007 The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti-apoptotic, and anti-differentiation signal. Several micro RNAs (miRs)
Baserga, Renato +5 more
core +2 more sources