Results 101 to 110 of about 7,833 (210)

Medicinal Chemistry Strategies for the Development of Bruton’s Tyrosine Kinase Inhibitors against Resistance

, 2022
Despite significant efficacy, one of the major limitations of small-molecule Bruton’s tyrosine kinase (BTK) agents is the presence of clinically acquired resistance, which remains a major clinical challenge.
Ji-Bo Kang (12576586), Xin Xue (450714), Yi-Yuan Ma (12576589), Ning Ding (456674), Nian-Guang Li (766204), Zhi-Hao Shi (714389), Peng Cao (107508), Liang Chang (531083), Shan-Liang Sun (3830662), Shi-Han Wu (12576583), Lu Chen (75170)   +10 more
core   +1 more source

Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis

JCI Insight, 2020
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum.
Johann E. Gudjonsson, Lam C. Tsoi, Feiyang Ma, Allison C. Billi, K.R. van Straalen, A.R.J.V. Vossen, H.H. van der Zee, Paul W. Harms, Rachael Wasikowski, Christine M. Yee, Syed M. Rizvi, Xianying Xing, Enze Xing, Olesya Plazyo, Chang Zeng, Matthew T. Patrick, Margaret M. Lowe, Richard E. Burney, Jeffrey H. Kozlow, Jill R. Cherry-Bukowiec, Yanyun Jiang, Joseph Kirma, Stephan Weidinger, Kelly C. Cushing, Michael D. Rosenblum, Celine Berthier, Amanda S. MacLeod, John J. Voorhees, Fei Wen, J. Michelle Kahlenberg, Emanual Maverakis, Robert L. Modlin, Errol P. Prens   +32 more
doaj   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Bruton’s Tyrosine Kinase Inhibition for the Treatment of Rheumatoid Arthritis

ImmunoTargets and Therapy, 2021
Laura C Arneson,1,* Kristen J Carroll,1,* Eric M Ruderman2 1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; 2Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School ...
Arneson LC, Carroll KJ, Ruderman EM
doaj  

Stage‐Dependent Transcriptional Reprogramming of B‐Cell Receptor Signaling and Antigen Presentation During Bovine Leukemia Virus–Driven Lymphomagenesis

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Bovine leukemia virus (BLV), an oncogenic deltaretrovirus, establishes lifelong infection in cattle and induces enzootic bovine leukosis in a subset of animals following prolonged latency. Despite extensive evidence of immune dysregulation, stage‐specific transcriptional reprogramming of B cells, the primary viral reservoir remains ...
Mohammad Mehdi Akbarin, Zahra Farjami, Cecilia Rodríguez Murillo, Víctor David González‐Fernández, Gabriel Eduardo Acevedo‐Jiménez, Lucero de María Ávila‐De la Vega, Hugo Ramírez Álvarez   +6 more
wiley   +1 more source

Bruton’s tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma

, 2018
Aberrant activation of anaplastic lymphoma kinase (ALK) can cause sporadic and familial neuroblastoma. Using a proteomics approach, we identified Bruton’s tyrosine kinase (BTK) as a novel ALK interaction partner, and the physical interaction was ...
Chan, Wai Yee, Lars Rönnstrand, Bo Feng, Li, Tianfeng, Zhao, Hui, Li, Tianfeng,, Chan, Sun On,, Tian, Ruijun, Yi Deng, Julhash U. Kazi, Rönnstrand, Lars, Sun On Chan, Shi, Yu,, Zou, Lin, Ruijun Tian, Deng, Yi,, Chan, Wai Yee,, Tian, Ruijun,, Kazi, Julhash U., Deng, Yi, Feng, Bo, Hui Zhao, Tianfeng Li, Zou, Lin,, Feng, Bo,, Sun, Jianmin,, Jianmin Sun, Rönnstrand, Lars,, Yu Shi, Chen, Yonglong,, Chen, Yonglong, Wai Yee Chan, Lin Zou, Yonglong Chen, Chan, Sun On, Kazi, Julhash U.,, Sun, Jianmin, Lund University., Shi, Yu, Zhao, Hui,   +39 more
core   +1 more source

Editorial: New Insights on Bruton’s Tyrosine Kinase Inhibitors

Frontiers in Immunology, 2021
C. I. Edvard Smith, Jennifer R. Brown, Rula Zain, Rula Zain   +3 more
doaj   +1 more source

Profound Sinoatrial Arrest Associated with Ibrutinib

Case Reports in Oncological Medicine, 2017
Background. Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for second-line treatment for mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and Waldenström macroglobulinemia.
Kanupriya Mathur, Aditya Saini, Kenneth A. Ellenbogen, Richard K. Shepard   +3 more
doaj   +1 more source

Acalabrutinib Versus Venetoclax Plus Obinutuzumab in Treatment‐Naive Chronic Lymphocytic Leukemia: A Real‐World Propensity Score‐Matched Study

Cancer Medicine, Volume 15, Issue 6, June 2026.
In a real‐world matched cohort study of treatment‐naïve TP53 wild‐type CLL patients, venetoclax plus obinutuzumab demonstrated significantly longer time to next treatment and improved 4‐year overall survival compared to first‐line acalabrutinib. Despite higher rates of cytopenias and infections, the venetoclax‐based regimen showed superior efficacy ...
Po‐Wei Liao, Bor‐Sheng Ko, Yu‐Chen Su, Wei‐Ting Chao, Chieh‐Lin Jerry Teng   +4 more
wiley   +1 more source

"Screening of the Bruton Tyrosine Kinase (BTK) Gene Mutations in 13 Iranian Patients with Presumed X-Linked Agammaglobulinemia "

Iranian Journal of Allergy, Asthma and Immunology, 2004
X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the Bruton tyrosine kinase (Btk) gene. In order to identify the mutations in Btk gene in Iranian patients with antibody deficiency, 13 male patients with an XLA phenotype ...
"Asghar Aghamohammadi, Nima Parvaneh, Hirokazu Kanegana, Mostafa Moin, Ali Akbar Amirzargar, Abolhassan Farhoudi, Zahra Pourpak, Masoud Movahedi, Mohammad Gharagozlou, Nima Rezaei, Takeshi Futatani, Toshio Miyawaki "   +11 more
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