Results 81 to 90 of about 212,526 (280)

Additional file 2: Figure S1. of Highly selective inhibition of Brutonâ s tyrosine kinase attenuates skin and brain disease in murine lupus

, 2018
Flow cytometry gating strategy. Cortical and choroid plexus tissue from MRL/lpr mice treated or not with BI-BTK-1 were analyzed by flow cytometric analysis. Red arrows denote sequential gated population (red boxes). Black arrows denote sequential non-gated population. (DOCX 358 kb)
Chalmers, Samantha, Wen, Jing, Doerner, Jessica, Stock, Ariel, Cuda, Carla, Makinde, Hadijat, Perlman, Harris, Bosanac, Todd, Webb, Deborah, Nabozny, Gerald, Fine, Jay, Klein, Elliott, Ramanujam, Meera, Putterman, Chaim   +13 more
openaire   +1 more source

Psoralen and ultraviolet A light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packing [PDF]

, 2016
Psoralen and ultraviolet A light (PUNTA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft versus-host disease.
Compernolle, Veerle, Devloo, Rosalie, Feys, Hendrik, Sandra, Koen, t'Kindt, Ruben, Van Aelst, Britt, Vandekerckhove, Philippe, Zachée, Pierre   +7 more
core   +2 more sources

Clinical pharmacology and PK/PD translation of the second-generation Bruton’s tyrosine kinase inhibitor, zanubrutinib

Expert Review of Clinical Pharmacology, 2021
Introduction: Bruton’s tyrosine kinase (BTK) inhibitors have revolutionized the treatment of B-cell lymphomas. Zanubrutinib was designed to achieve improved therapeutic concentrations and minimize off-target activities putatively accounting, in part, for
C. Tam, Y. Ou, J. Trotman, Stephen Samuel Opat   +3 more
semanticscholar   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source

Additional file 1: Table S1. of HM71224, a novel Brutonâ s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

, 2016
Sequence alignment of kinases. Table S2. Arthritis score and body weight during treatment period. Figure S1. Experimental design of collagen-induced arthritis. Figure S2. Effect of HM71224 on EGFR signaling. Figure S3. HM71224 inhibits Btk phosphorylation. Figure S4. HM71224 inhibits osteoclastogenesis. Figure S5.
Park, Jin, Joo-Yun Byun, Park, Ji, Yu-Yon Kim, Lee, Ye, Oh, Jeong, Jang, Sun, Kim, Young, Song, Yeong, Jeewoong Son, Kwee Suh, Lee, Young-Mi, Lee, Eun   +12 more
openaire   +1 more source

Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

Nature Communications, 2015
Inflammasome activation has been implicated in various inflammatory diseases including post-ischaemic inflammation after stroke. Inflammasomes mediate activation of caspase-1, which subsequently induces secretion of pro-inflammatory cytokines such as IL ...
Minako Ito, T. Shichita, Masahiro Okada, Ritsuko Komine, Yoshiko Noguchi, Akihiko Yoshimura, R. Morita   +6 more
semanticscholar   +1 more source

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

Chemistry – A European Journal, EarlyView.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti, Jennifer A. Miles, George J. Wade, Scott Grossman, George W. Preston, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam Nelson   +8 more
wiley   +1 more source

Bruton’s Tyrosine Kinase Inhibition as an Emerging Therapy in Systemic Autoimmune Disease [PDF]

, 2021
Stefan F. H. Neys, Jasper Rip, Rudi W. Hendriks, Odilia B. J. Corneth   +3 more
openalex   +1 more source

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model [PDF]

, 2014
X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency that results from mutations within the gene encoding Bruton’s tyrosine kinase (BTK). Many XLA-associated mutations affect splicing of BTK pre-mRNA and severely impair B cell development ...
Behlke, Mark A, Berglöf, Anna, Bestas, Burcu, Blomberg, K Emelie M, El Andaloussi, Samir, Gait, Michael J, Gustafsson, Manuela O, Guterstam, Peter, Kharazi, Shabnam, Lundin, Karin E, Mohammad, Dara K, Moreno, Pedro M D, Månsson, Robert, Nordin, Joel Z, Piątosa, Barbara, Roberts, Thomas C, Saleh, Amer F, Smith, C I Edvard, Sutlu, Tolga, Wengel, Jesper, Wood, Matthew J A   +20 more
core   +1 more source

Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease

Acta Neuropathologica, 2020
Anti-CD20-mediated B-cell depletion effectively reduces acute multiple sclerosis (MS) flares. Recent data shows that antibody-mediated extinction of B cells as a lasting immune suppression, harbors the risk of developing humoral deficiencies over time ...
Sebastian Torke, Roxanne Pretzsch, Darius Häusler, P. Haselmayer, R. Grenningloh, U. Boschert, W. Brück, Martin S. Weber   +7 more
semanticscholar   +1 more source