Results 71 to 80 of about 212,526 (280)

Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib [PDF]

, 2017
The Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib induces platelet dysfunction and causes increased risk of bleeding. Off-target inhibition of Tec is believed to contribute to platelet dysfunction and other side-effects of ibrutinib.
Appleby, Niamh, Bruce, David, Bye, Alex P., Desborough, Michael J., Gibbins, Jon M., Hildyard, Catherine A. T., Hughes, Craig E., Kriek, Neline, Nock, Sophie H., Sage, Tanya, Unsworth, Amanda J.   +10 more
core   +2 more sources

The Different Faces of Chronic Lymphocytic Leukemia -Two Clinical Cases [PDF]

Journal of Biomedical & Clinical Research, 2020
Chronic lymphocytic leukemia is one of the most common types of leukemia affecting adults over 65 years of age [1]. The disease is a part of the so-called indolent lymphomas and has a variable clinical course, defined by many factors.
Vanya Popova, Kalina Ignatova, Dobromir Nguen, Pencho Tonchev, Doroteya Todorieva, Lachezar Bogdanov   +5 more
doaj   +3 more sources

MOESM11 of Enhanced Brutonâ s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

, 2019
Additional file 11: Methods S1. Procedures of mouse experiments.
Heukels, Peter, Hulst, Jennifer, Nimwegen, Menno, Carian Boorsma, Melgert, Barbro, Thusen, Jan, Blink, Bernt, Hoek, Rogier, Miedema, Jelle, Neys, Stefan, Corneth, Odilia, Hendriks, Rudi, Wijsenbeek, Marlies, Kool, Mirjam   +13 more
openaire   +1 more source

Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome [PDF]

, 2008
Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with `cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent ...
Alessandro Plebani, Anna Breborowicz, Bodo Grimbacher, Cristina Pietrogrande, Cristina Woellner, Doerte Thiel, Ellen Renner, Horwood NJ, Jiri Litzman, Jose L. Franco, Mehdi Yeganeh, Nima Rezaei, Nuria Matamoros, Ozden Sanal, Philipp Henneke, Sara S. Kilic, Simon Rothenfusser, Stephan Ehl, Teresa Espanol, Thomas R. Hawn   +19 more
core   +1 more source

Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition.

Biochimica et Biophysica Acta - General Subjects, 2020
BACKGROUND Bruton's tyrosine kinase (BTK) is a key component of the B-cell receptor (BCR) pathway and a clinically validated target for small molecule inhibitors such as ibrutinib in the treatment of B-cell malignancies.
Albert C Liclican, Loredana Serafini, Weimei Xing, G. Czerwieniec, B. Steiner, Ting Wang, K. Brendza, J. Lutz, K. Keegan, A. Ray, B. Schultz, R. Sakowicz, Joy Y. Feng   +12 more
semanticscholar   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

MOESM8 of Enhanced Brutonâ s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

, 2019
Additional file 8: Figure S8. Increased proportions of IgA+ GC B-cells and IgA+ plasma cells in lungs in mice exposed to saline and bleomycin. (A) Flow cytometric quantification of IgA+ GC B-cells (CD19+CD95+IgDlowIgA+) as percentage of GC B-cells and (B) IgA+ plasma cells (CD19lowCD138+IgA+) as percentage of plasma cells in lungs of mice exposed to ...
Heukels, Peter, Hulst, Jennifer, Nimwegen, Menno, Carian Boorsma, Melgert, Barbro, Thusen, Jan, Blink, Bernt, Hoek, Rogier, Miedema, Jelle, Neys, Stefan, Corneth, Odilia, Hendriks, Rudi, Wijsenbeek, Marlies, Kool, Mirjam   +13 more
openaire   +1 more source

Invasive aspergillosis related to ibrutinib therapy for chronic lymphocytic leukemia

Respiratory Medicine Case Reports, 2017
We report a case of invasive pulmonary aspergillosis in a patient taking ibrutinib, a Bruton's tyrosine kinase inhibitor used to treat refractory chronic lymphocytic leukemia.
Benjamin Arthurs, MD, Kathy Wunderle, MD, Maylee Hsu, MD, Suil Kim, MD, PhD   +3 more
doaj   +1 more source

Additional file 1: Table S1. of Highly selective inhibition of Brutonâ s tyrosine kinase attenuates skin and brain disease in murine lupus

, 2018
Antibodies utilized for choroid plexus flow cytometric analysis. (DOCX 12 kb)
Chalmers, Samantha, Wen, Jing, Doerner, Jessica, Stock, Ariel, Cuda, Carla, Makinde, Hadijat, Perlman, Harris, Bosanac, Todd, Webb, Deborah, Nabozny, Gerald, Fine, Jay, Klein, Elliott, Ramanujam, Meera, Putterman, Chaim   +13 more
openaire   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source