Results 61 to 70 of about 7,833 (210)
Aminopyrazole Carboxamide Bruton’s Tyrosine
Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group
Tuning
, 2018 Potent
covalent inhibitors of Bruton’s tyrosine kinase (BTK)
based on an aminopyrazole carboxamide scaffold have been identified.
Compared to acrylamide-based covalent reactive groups leading to irreversible
protein adducts, cyanamide-based reversible ...Zhao-Kui Wan (2004907), Brian M. Juba (4587880), John I. Trujillo (2299687), Jeffrey F. Ohren (2189149), Stephen E. Benoit (6054389), Kyung-Hee Kim (617163), Arthur J. Wittwer (6054410), John Douhan (6054416), Nelson Huang (2438155), Thomas N. O’Connell (6054404), Erica Liu (5585105), Christoph W. Zapf (2019895), Nicole Caspers (1811215), Daniel P. Walker (2124721), Robert O. Hughes (2139538), Mihir D. Parikh (3840538), Venkataraman Thanabal (2367781), Mark E. Schnute (2122345), Erin McCarthy (6054395), John R. Springer (6054407), Joy S. Miyashiro (6054398), Rajeev Hotchandani (2351023), Jane M. Withka (2025886), Li Xing (35790), Shaun R. Selness (2363620), Nancy L. Wood (6054413), Margaret L. Grapperhaus (3011067), Seungil Han (1811221), Dean Messing (5730854), Ingrid P. Buchler (6054392), Shashi Mohan (6054401), Michelle Schmidt (2122342) +31 morecore +1 more sourceBruton’s tyrosine kinase is a possible therapeutic target in microscopic polyangiitis
Arthritis Research & Therapy, 2023 Background Bruton’s tyrosine kinase (Btk) is an enzyme expressed in leukocytes other than T lymphocytes and plasma cells and involved in B-cell receptor- and Fcγ receptor (FcγR)-mediated signal transduction.Issei Nakade, Yuto Tamura, Fuyu Hashimoto, Yuko Ariza, Shingo Hotta, Hirofumi Fujigaya, Suishin Arai, Mai Taniguchi, Hodaka Ogawa, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu +13 moredoaj +1 more sourceSequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food
Allergy, EarlyView.ABSTRACT
Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger +7 morewiley +1 more sourceCharacterization of Bruton’s Tyrosine Kinase Gene and Protein from Marine Sponge Suberites domuncula
, 2012 Bruton’s tyrosine kinase (Btk) is a member of Tec family of protein tyrosine kinases. It is expressed
in B cells and myeloid cells in humans and it is crucial for maturation of B-lineage lymphoid
cells.Andreja Mikoč, Matija Harcet, Mirna Imešek, Ćetković, Helena, Perina, Drago, Harcet, Matija, Mikoč, Andreja, Drago Perina, Dujo Sladojević, Brcko, Ana, Imešek, Mirna, Ana Brcko, Sladojević, Dujo, Helena Ćetković +13 morecore +1 more sourceUnmet Needs in Treatment Escalation for Chronic Spontaneous Urticaria: Findings From the CURE Registry
Allergy, EarlyView.Appropriate treatment escalation improves CSU disease control. However, only about a quarter of patients achieve a complete response, the main goal of CSU treatment. Approximately one‐third of patients clinically eligible for escalation (UCT < 12) do not receive guideline‐recommended treatment escalation and remain symptomatic on their current ...Pavel Kolkhir, Pascale Salameh, Magdalena Zajac, Alicja Kasperska‐Zajac, Ana Giménez‐Arnau, Maria Puertolas, Hanna Bonnekoh, Carolina Vera Ayala, Michael Makris, Eleni Chatzidimitriou, Stamatios Gregoriou, Kanokvalai Kulthanan, Andrea Bauer, Mojca Bizjak‐Suran, Daria Fomina, Alexis Bocquet, Joachim Dissemond, Mohamed Abuzakouk, Tara Raftery, Nadine Chapman‐Rothe, Emek Kocatürk, Clive Grattan, Riccardo Asero, Jonny G. Peter, Simon Francis Thomsen, Karsten Weller +25 morewiley +1 more sourceSilencing of Bruton’s tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA)
, 2002 Tec family tyrosine kinases, Bruton’s tyrosine kinase (Btk), Itk, Bmx, Tec, and Txk, are multi-domain proteins involved in hematopoietic signaling. Here, we demonstrate that human Btk protein can transiently be depleted using double-stranded short RNA ...Beston F. Nore, Heinonen, Juhana E., Nore, Beston F., Smith, C.I.Edvard, C.I.Edvard Smith, Nore, BF, Smith, CIE, Heinonen, JE, Juhana E. Heinonen +8 morecore +1 more sourceAdvancements in research on the cardiovascular toxicity caused by TEC family kinases inhibitors
Frontiers in PharmacologyThe tyrosine kinase expressed in hepatocellular carcinoma (TEC) family kinases (TFKs) are a subfamily of non-receptor protein tyrosine kinases (PTKs) that include five members: TEC, bruton’s tyrosine kinase (BTK), interleukin 2-inducible T-cell kinase ...Yi Zhang, Huangxi Fu, Xingchen Kang, Zixuan Qiu, Hao Yan, Qiaojun He, Qiaojun He, Qiaojun He, Bo Yang, Bo Yang, Bo Yang, Zhifei Xu, Peihua Luo, Peihua Luo +13 moredoaj +1 more sourceThe International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria
Allergy, EarlyView.ABSTRACT
This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...T. Zuberbier, Z. Abdul Hameed Ansari, A. H. Abdul Latiff, M. M. Abuzakouk, M. S. Agcaoili‐De Jesus, R. C. Agondi, M. Al‐Ahmad, A. A. Alangari, H. Alhameli, C. D. Alonso Bello, S. Alshareef, S. Al‐Tamemi, S. Altrichter, H. Al Wahshi, S. Aquilina, M. Araújo, R. Arnaout, R. Asero, B. Ballmer‐Weber, C. Bangert, A. Bauer, M. Ben‐Shoshan, J. A. Bernstein, C. Bindslev‐Jensen, M. Bizjak, I. Boccon‐Gibod, H. Bonnekoh, L. Bouillet, K. Brockow, Z. Brzoza, M. Bulatović Ćalasan, A. Bulkhi, T. Buttgereit, A. Bygum, T. Caballero, O. Calderon, R. Campos, M. Cancian, E. Carne, M. A. Castor, I. Cerecedo, T. Çetinarslan, I. Cherrez‐Ojeda, N. Chkhikvadze, H. J. Chong‐Neto, K. Choo, G. Christoff, C.‐Y. Chu, K. Ciupka, N. Conlon, C. Costa, T. Craig, P. Criado, I. Danilycheva, R. Darlenski, E. De Arruda Chaves, L. de Montjoye, M. S. Doutre, A. Du‐Thanh, D. Ebo, S. Elkhalifa, S. Elmariah, T. El‐Shanawany, L. F. Ensina, R. Ertaş, R. Fachini Jardim Criado, M. Ferrer, S. Ferrucci, J. S. Fok, D. Fomina, L. Fonacier, G. Fouda, I. Francescantonio, A. Fukunaga, C. A. Galvan Calle, E. Garcia, K. Gáspár, A. Gelincik, S. Geng, K. Godse, M. Gonçalo, M. Gotua, C. Grattan, M. Grosber, G. Guidos Fogelbach, M. Guilarte, R. Guillod, E. Hamelmann, J. Hawkes, K. Hayama, R. Heuer, M. Hide, W. Hoetzenecker, N. Inomata, H.‐R. Kang, A. Kaplan, A. Kapp, M. Karam, A. Kasperska‐Zajac, C. H. Katelaris, A. Kessel, M. Khoshkhui, B. Kim, T. Kinaciyan, E. Kocatürk, M. Kolacinska‐Flont, P. Kolkhir, G. N. Konstantinou, M. Kosnik, D. Krasowska, K. Kulthanan, M. S. Kumaran, I. Kuprys‐Lipinska, M. Labrador, J. I. Larco, D. Larenas‐Linnemann, E. Latysheva, E. Lazaridou, P. H. Li, H. Lima, U. Lippert, M. Magerl, M. Makris, J. Alves Marcelino, A. V. Marzano, I. Medina, R. Meshkova, D. Micallef, R. Mohammed Ali, C. G. Mortz, M. Munoz, H. N. G. Oude Elberink, A. Nakonechna, I. Nasr, A. Nast, E. Netchiporouk, E. Nettis, S. Nieto, I. Ogueta Canales, T.‐L. Okas, R. L. Orfali, E. Özkaya, C. Parisi, A. Pennitz, R. Pawankar, M. P. Pereira, J. Peter, E. Petkova, P. D. Pigatto, I. Podder, T. Popov, G. Porebski, P. Pyatilova, G. D. Ramon, H. A. Ratti Sisa, M. Recto, K. Ress, K. Ridge, M. Riedl, C. Ritchie, N. Rosario Filho, I. Rosmaninho, M. Rudenko, M. Rukhadze, K. Rutkowski, V. Sabato, U. M. Sahiner, S. Saini, F. Saleh Al Sabbagh, A. Salman, F. Salvo, J. Sanchez, A. Santucci, S. Schliemann, P. Schmid‐Grendelmeier, B. E. Sekerel, F. Serpa, F. Sheikh, J. Sheikh, H. Shendi, F. Siebenhaar, M. Sonomjamts, A. Soria, B. Sousa Pinto, M. Staevska, P. Staubach, M. Stephan, K. Stevanovic, L. Stingeni, M. Stobiecki, Ö. Su Küçük, G. Sussman, A. Szegedi, S. Takahagi, A. Tanaka, N. Teovska Mitrevska, S. F. Thomsen, E. Toubi, F. Tsatsou, M. Turk, Z. Vadasz, A. Valerieva, S. Valle, M. v. Doorn, B. Veleiro Perez, C. E. Vera Ayala, C. Vestergaard, R. J. Vieira, C. W. Maruta, B. Wedi, R. N. Werner, E. W. Y. Yap, P. Xepapadaki, Y. Xiang, Y.‐M. Ye, P. Yong, G. Yosipovitch, A. Z. J. Zalewska‐Janowska, C. Zeyen, Z. Zhao, M. Metz, A. M. Giménez‐Arnau +221 morewiley +1 more source
