Results 41 to 50 of about 578,179 (195)

MOESM9 of Enhanced Brutonâ s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

, 2019
Additional file 9:. Graphic summary of B-cell subset alterations and autoreactive IgA induction in IPF patients. Immature B cells leave the bone marrow as transitional B-cells for further differentiation. Decrease in circulating transitional B-cells together with their increase in IPF lungs suggest homing towards pulmonary tertiary lymphoid organs (TLO)
Heukels, Peter, Hulst, Jennifer, Nimwegen, Menno, Boorsma, Carian, Melgert, Barbro, Thusen, Jan, Blink, Bernt, Hoek, Rogier, Miedema, Jelle, Neys, Stefan, Corneth, Odilia, Hendriks, Rudi, Wijsenbeek, Marlies, Kool, Mirjam   +13 more
openaire   +1 more source

Discovery of Reversible Covalent Bruton’s Tyrosine Kinase Inhibitors PRN473 and PRN1008 (Rilzabrutinib)

, 2022
Bruton’s tyrosine kinase (BTK), a Tec family tyrosine kinase, is critical in immune pathways as an essential intracellular signaling element, participating in both adaptive and immune responses. Currently approved BTK inhibitors are irreversible covalent
Erik J. Verner (12262211), Ronald J. Hill (767985), Danny Tam (2155843), Tony Ton (1833715), Dane Karr (12262220), Helena Haberstock-Debic (12262226), Michael J. Taylor (2722960), Michelle Francesco (12262217), Claire L. Langrish (12262232), Ken A. Brameld (1833838), Angelina Bisconte (12262214), David Finkle (7908488), Xiaoyan Li (117291), Yan Xing (329805), Jin Shu (4276552), Jiang Zhu (40858), Eun Ok Kim (192394), Jacob LaStant (4276555), Natalie Loewenstein (12262223), Philip Nunn (12262229), J. Michael Bradshaw (2461786), David M. Goldstein (1692562), Mohammad R. Masjedizadeh (2700271), Timothy D. Owens (1692559)   +23 more
core   +1 more source

Additional file 2: Figure S1. of Highly selective inhibition of Brutonâ s tyrosine kinase attenuates skin and brain disease in murine lupus

, 2018
Flow cytometry gating strategy. Cortical and choroid plexus tissue from MRL/lpr mice treated or not with BI-BTK-1 were analyzed by flow cytometric analysis. Red arrows denote sequential gated population (red boxes). Black arrows denote sequential non-gated population. (DOCX 358 kb)
Chalmers, Samantha, Wen, Jing, Doerner, Jessica, Stock, Ariel, Cuda, Carla, Makinde, Hadijat, Perlman, Harris, Bosanac, Todd, Webb, Deborah, Nabozny, Gerald, Fine, Jay, Klein, Elliott, Ramanujam, Meera, Putterman, Chaim   +13 more
openaire   +1 more source

Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib

Case Reports in Infectious Diseases, 2016
Cryptococcus is a unique environmental fungus that can cause disease most often in immunocompromised individuals with defective cell-mediated immunity. Chronic lymphocytic leukemia (CLL) is not known to be a risk factor for cryptococcal disease although ...
Koh Okamoto, Laurie A. Proia, Patricia L. Demarais   +2 more
doaj   +1 more source

Additional file 1: Table S1. of Highly selective inhibition of Brutonâ s tyrosine kinase attenuates skin and brain disease in murine lupus

, 2018
Antibodies utilized for choroid plexus flow cytometric analysis. (DOCX 12 kb)
Chalmers, Samantha, Wen, Jing, Doerner, Jessica, Stock, Ariel, Cuda, Carla, Makinde, Hadijat, Perlman, Harris, Bosanac, Todd, Webb, Deborah, Nabozny, Gerald, Fine, Jay, Klein, Elliott, Ramanujam, Meera, Putterman, Chaim   +13 more
openaire   +1 more source

Additional file 1: Table S1. of HM71224, a novel Brutonâ s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

, 2016
Sequence alignment of kinases. Table S2. Arthritis score and body weight during treatment period. Figure S1. Experimental design of collagen-induced arthritis. Figure S2. Effect of HM71224 on EGFR signaling. Figure S3. HM71224 inhibits Btk phosphorylation. Figure S4. HM71224 inhibits osteoclastogenesis. Figure S5.
Park, Jin, Byun, Joo-Yun, Park, Ji, Kim, Yu-Yon, Lee, Ye, Oh, Jeong, Jang, Sun, Kim, Young, Song, Yeong, Son, Jeewoong, Suh, Kwee, Lee, Young-Mi, Lee, Eun   +12 more
openaire   +1 more source

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase [PDF]

, 2001
After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. The two latter proteins
Magnan, A, Anne Gillet, Arrieumerlou, C, Antoine Magnan, Boyer, C, Malissen, Bernard, Vincenzo Di Bartolo, Mireille Richelme, Marie Malissen, Lin, YL, Gillet, A., Roure, A, Mura, A. M., Boyer, C., Malissen, B, Arrieumerlou, C., Malissen, M., Malissen, M, Roure, A., Richelme, M, Acuto, O, Lin, Y. L., Bernard Malissen, Claude Boyer, Malissen, B., Di Bartolo, V, Cécile Arrieumerlou, Yea-Lih Lin, Agnès Roure, Oreste Acuto, Mura, AM, Acuto, O., Richelme, M., Acuto, Oreste, Di Bartolo, V., Anne-Marie Mura, Gillet, A, Boyer, Claudine, Magnan, A.   +38 more
core   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]

, 2012
MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Jørgensen, Heather G., Holyoake, T.L., Holyoake, T., Abed El Baky, Mohamed, Bartholomew, C., Melo, Junia V., Roy, P., Melo, J.V., Abed El Baky, M., Roy, S., Jørgensen, H., Jorgensen, H.G., Strathdee, G., Strathdee, Gordon, Melo, J., Roy, Swagata, Holyoake, Tessa L., Roy, Poornima, Bartholomew, Christopher   +18 more
core   +1 more source

The Different Faces of Chronic Lymphocytic Leukemia -Two Clinical Cases [PDF]

Journal of Biomedical & Clinical Research, 2020
Chronic lymphocytic leukemia is one of the most common types of leukemia affecting adults over 65 years of age [1]. The disease is a part of the so-called indolent lymphomas and has a variable clinical course, defined by many factors.
Vanya Popova, Kalina Ignatova, Dobromir Nguen, Pencho Tonchev, Doroteya Todorieva, Lachezar Bogdanov   +5 more
doaj   +3 more sources