Results 31 to 40 of about 578,179 (195)
Discovery of LOU064
(Remibrutinib), a Potent and Highly
Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
, 2020 Bruton’s tyrosine
kinase (BTK), a cytoplasmic tyrosine kinase,
plays a central role in immunity and is considered an attractive target
for treating autoimmune diseases.Christian Beerli, Alexandra Hinniger, Alexandra Hinniger (7376633), Philipp Janser (2019583), Bruno Cenni (7376639), Sascha Gutmann (1570942), Rudolf Wälchli, Amanda Littlewood-Evans, Daniela Angst (2019604), Bruno Cenni, Enrico G. Funhoff, Philipp Janser, Christian Beerli (395445), Sascha Gutmann, Barbara Nuesslein-Hildesheim, Anna Vulpetti (402927), Daniela Angst, Clemens Scheufler, Anna Vulpetti, Janet Dawson, Rudolf Wälchli (8532807), François Gessier, Alfred Zimmerlin, Robert Pulz (3065607), Grazyna Wieczorek (8532810), François Gessier (8532804), Alfred Zimmerlin (2153527), Robert Pulz, Janet Dawson (762808), Grazyna Wieczorek, Clemens Scheufler (2819311), Amanda Littlewood-Evans (263940), Enrico G. Funhoff (2945997), Barbara Nuesslein-Hildesheim (395451) +33 morecore +3 more sourcesMOESM7 of Enhanced Brutonâ s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis
, 2019 Additional file 7: Figure S7. Gating strategy for B-cell subsets in mice. Representative gating strategy used for mice experiments for the identification of GC B-cells (CD19+CD95+IgDlow), IgA GC B-cells (CD19+CD95+IgDlowIgA+), plasma cells (CD19lowCD138+) and IgA+ plasma cells (CD19lowCD138+IgA+).Heukels, Peter, Hulst, Jennifer, Nimwegen, Menno, Boorsma, Carian, Melgert, Barbro, Thusen, Jan, Blink, Bernt, Hoek, Rogier, Miedema, Jelle, Neys, Stefan, Corneth, Odilia, Hendriks, Rudi, Wijsenbeek, Marlies, Kool, Mirjam +13 moreopenaire +1 more sourceComplex formation of EphB1/Nck/Caskin1 leads to tyrosine phosphorylation and structural changes of the Caskin1 SH3 domain. [PDF]
, 2012 Scaffold proteins have an important role in the regulation of signal propagation. These proteins do
not possess any enzymatic activity but can contribute to the formation of multiprotein complexes.Roopesh Udupa, Bőgel Gábor, Annamária Balázs, Gábor Bőgel, Udupa Roopesh, Szabó Beáta, Beáta Szabó, Balázs Annamária, Balázs, Annamária, Fekete Anna, Buday László, Pesti Szabolcs, Szabolcs Pesti, László Buday, Pesti, Szabolcs, Anna Fekete, Udupa, Roopesh +16 morecore +1 more sourceEnhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry
Nature Communications, 2020 PROTACs have emerged as promising therapeutic agents but their cellular uptake is often inefficient. Here, the authors show that reversible covalent warhead chemistry improves PROTAC intracellular accumulation and target engagement, and develop a dual ...Wen-Hao Guo, Xiaoli Qi, Xin Yu, Yang Liu, Chan-I Chung, Fang Bai, Xingcheng Lin, Dong Lu, Lingfei Wang, Jianwei Chen, Lynn Hsiao Su, Krystle J. Nomie, Feng Li, Meng C. Wang, Xiaokun Shu, José N. Onuchic, Jennifer A. Woyach, Michael L. Wang, Jin Wang +18 moredoaj +1 more sourceMOESM11 of Enhanced Brutonâ s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis
, 2019 Additional file 11: Methods S1. Procedures of mouse experiments.Heukels, Peter, Hulst, Jennifer, Nimwegen, Menno, Boorsma, Carian, Melgert, Barbro, Thusen, Jan, Blink, Bernt, Hoek, Rogier, Miedema, Jelle, Neys, Stefan, Corneth, Odilia, Hendriks, Rudi, Wijsenbeek, Marlies, Kool, Mirjam +13 moreopenaire +1 more sourceThe new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs
Haematologica, 2019
Tyrosine kinases have been implicated in promoting tumorigenesis of several human cancers. Exploiting these vulnerabilities has been shown to be an effective anti-tumor strategy as demonstrated for example by the Bruton's tyrosine kinase (BTK) inhibitor,Debora Soncini, Stefania Orecchioni, Samantha Ruberti, Paola Minetto, Claudia Martinuzzi, Luca Agnelli, Katia Todoerti, Antonia Cagnetta, Maurizio Miglino, Marino Clavio, Paola Contini, Riccardo Varaldo, Micaela Bergamaschi, Fabio Guolo, Mario Passalacqua, Alessio Nencioni, Fiammetta Monacelli, Marco Gobbi, Antonino Neri, Giovanni Abbadessa, Sudharshan Eathiraj, Brian Schwartz, Francesco Bertolini, Roberto M. Lemoli, Michele Cea +24 moredoaj +1 more sourceMOESM10 of Enhanced Brutonâ s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis
, 2019 Additional file 10: Table S1. Overview of antibodies used for experiments.Heukels, Peter, Hulst, Jennifer, Nimwegen, Menno, Boorsma, Carian, Melgert, Barbro, Thusen, Jan, Blink, Bernt, Hoek, Rogier, Miedema, Jelle, Neys, Stefan, Corneth, Odilia, Hendriks, Rudi, Wijsenbeek, Marlies, Kool, Mirjam +13 moreopenaire +1 more sourceThe protein tyrosine kinases EpsB and PtkA differentially affect biofilm formation in Bacillus subtilis [PDF]
, 2014 The Gram-positive soil bacterium Bacillus subtilis is able to choose between motile and sessile lifestyles. The sessile way of life, also referred to as biofilm, depends on the formation of an extracellular polysaccharide matrix and some extracellular ...Stanley-Wall, Nicola, Stuelkel, Joerg, Gunka, Katrin, Stülke, Jörg, Stanley-Wall, Nicola; id_orcid, Gerwig, Jan, Kiley, Taryn B. +6 morecore +1 more sourceMOESM8 of Enhanced Brutonâ s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis
, 2019 Additional file 8: Figure S8. Increased proportions of IgA+ GC B-cells and IgA+ plasma cells in lungs in mice exposed to saline and bleomycin. (A) Flow cytometric quantification of IgA+ GC B-cells (CD19+CD95+IgDlowIgA+) as percentage of GC B-cells and (B) IgA+ plasma cells (CD19lowCD138+IgA+) as percentage of plasma cells in lungs of mice exposed to ...Heukels, Peter, Hulst, Jennifer, Nimwegen, Menno, Boorsma, Carian, Melgert, Barbro, Thusen, Jan, Blink, Bernt, Hoek, Rogier, Miedema, Jelle, Neys, Stefan, Corneth, Odilia, Hendriks, Rudi, Wijsenbeek, Marlies, Kool, Mirjam +13 moreopenaire +1 more source
