Results 11 to 20 of about 7,833 (210)
Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity
Frontiers in Immunology, 2017 Bruton’s tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell receptor signaling in the development and functioning of adaptive immunity.
Alexander N. R. Weber +5 more
doaj +2 more sources
Novel Bruton’s Tyrosine Kinase (BTK) Substrates for Time-Resolved Luminescence Assays
, 2022 Bruton’s tyrosine kinase (BTK) is a well-documented target for cancer therapeutics due to its role in B-cell signaling pathways. However, inhibitor design is hindered by lack of tools to assess kinase activity.
Naomi E. Widstrom (12741873) +7 more
core +4 more sources
, 2020 Bruton’s tyrosine kinase (BTK), a cytoplasmic tyrosine kinase, plays a central role in immunity and is considered an attractive target for treating autoimmune diseases.
Christian Beerli +33 more
core +3 more sources
Antithrombotic prophylaxis in patients treated with Bruton’s tyrosine kinase inhibitors
, 2023 There is an increased risk of atrial fibrillation in patients treated with Bruton’s tyrosine kinase inhibitors such as ibrutinib or acalabrutinib. The risk of this complication, as in the general population, increases with the age of patients and the ...
Szmit, Sebastian; Department of Cardio-Oncology, Centre of Postgraduate Medical Education, Institute of Hematology and Transfusion Medicine in Warsaw, Poland; Department of Oncological Diagnostics and Cardio-Oncology, The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,, Poland
core +1 more source
Disruption of fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase [PDF]
, 2013 Fyn-deficient mice display increased AMP-activated Protein Kinase (AMPK) activity as a result of Fyn-dependent regulation of Liver Kinase B1 (LKB1) in skeletal muscle.
Bastie, Claire C. +6 more
core +1 more source
, 2022 Bruton’s tyrosine kinase (BTK), a Tec family tyrosine kinase, is critical in immune pathways as an essential intracellular signaling element, participating in both adaptive and immune responses. Currently approved BTK inhibitors are irreversible covalent
Erik J. Verner (12262211) +23 more
core +1 more source
Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase. [PDF]
PLoS ONE, 2013 Diminished Ikaros function has been implicated in the pathogenesis of acute lymphoblastic leukemia (ALL), the most common form of childhood cancer. Therefore, a stringent regulation of Ikaros is of paramount importance for normal lymphocyte ontogeny ...
Hong Ma +5 more
doaj +1 more source
Journal of Xenobiotics, 2023 Immune thrombocytopenic purpura (ITP) is an acquired antibody or cell-mediated platelet damage or decreased platelet production. Steroids, IV immunoglobulins (IVIG), and Rho-anti-D antibodies are the commonly used initial treatments for ITP.
Muhammad Ashar Ali +8 more
doaj +1 more source
Phylogeny of Tec Family Kinases: Identification of a Pre-Metazoan Origin of Btk, Bmx, Itk, Tec, Txk and the Btk Regulator SH3BP5 [PDF]
, 2008 It is generally considered mammals and birds have five Tec family kinases (TFKs): Btk, Bmx (also known as Etk), Itk, Tec, and Txk (also known as Rlk). Here, we discuss the domains and their functions and regulation in TFKs.
Ortutay, Csaba +7 more
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Disseminated fungal infection in a patient receiving zanubrutinib
Clinical Case Reports, 2023 Key Clinical Message We report a case of fatal disseminated aspergillosis in the setting of administration of zanubrutinib, a second‐generation Bruton's tyrosine kinase inhibitor thought to have a lower rate of immunosuppression‐related side effects.
Madalyn Walsh +3 more
doaj +1 more source