Results 191 to 200 of about 21,585 (263)

Longitudinal Proteomic Signatures of Dupilumab and Tralokinumab Treated Atopic Dermatitis Patients

Clinical and Translational Allergy, Volume 16, Issue 9, September 2026.
Although both dupilumab and tralokinumab effectively suppress core Th2 inflammation in atopic dermatitis, they exhibit divergent, treatment specific protein modulation. ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory disease driven by Type 2 (Th2) inflammation.
Wojciech Francuzik, Kristijan Pažur, Margitta Worm   +2 more
wiley   +1 more source

Lenvatinib enhances the response of biliary tract cancer to anti-HER2 therapy. [PDF]

Signal Transduct Target Ther
Sun H, Li S, Zhu Z, Yu G, Huang Z, Zhang N, Feng S, Li Y, Ning C, Xun Z, Xue J, Li D, Zhang L, Piao M, Li C, Li J, Sun B, Yang X, Wang H, Zhao H.   +19 more
europepmc   +1 more source

Recent Advances in Metal‐Organic Framework Photo‐Electrocatalysts for the Synthesis of Ammonia

Carbon Neutralization, Volume 5, Issue 5, September 2026.
This diagram illustrates the role of Metal‐Organic Frameworks (MOFs) in the photocatalytic and electrocatalytic synthesis of ammonia, highlighting their potential as efficient catalysts for sustainable nitrogen fixation under light irradiation and electrode excitation.
Jingjing Wang, Kaiyan Shi, Zhenlin Zhao, Yafu Wang, Ke Yang, Rui Ren, Jianqi Lu, Zhencheng Feng, Xiaojun Gu, Jiangwei Zhang   +9 more
wiley   +1 more source

The effects of castration on the quality of black Tibetan sheep meat and muscle metabolites. [PDF]

Food Sci Anim Resour
Xu X, Han L, Yue Q, Hou S, Luo Z, Gui L, Yang B, Wang Z, Yuan Z, Sun S.   +9 more
europepmc   +1 more source

Advances and challenges in immunotherapy for intrahepatic cholangiocarcinoma based on the tumour immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
This review integrates ICC‐specific and broader BTC evidence to define how desmoplastic stroma, immune‐cell crosstalk, metabolic remodelling, and molecular heterogeneity shape immunotherapy response and resistance. It highlights biomarker‐guided, mechanism‐based combinations while emphasizing the limited maturity of ICC‐specific evidence for emerging ...
Mengyao Chen, Shuofan Jin, Yuxuan Zhou, Jinkai Tong, Yufan Zhao, Quanjun Yang   +5 more
wiley   +1 more source

Real-world analysis of ctDNA and other biomarkers in patients with curatively resected stage I-III biliary tract cancer. [PDF]

ESMO Gastrointest Oncol
Malla M, Esmail A, Tin A, Khayat MM, Bathla L, Bridges C, Brewer CM, Ferguson J, Ortiz JB, Ensor J, Magee K, Yu J, He AR, Cannon T, Winer A, King GG, Mahipal A, Nagarajan A, Franses JW, Fungtammasan A, Jurdi A, Liu MC, Kodali S, Connor AA, Ghobrial RM, Kim RD, Abdelrahim M.   +26 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Benzimidazol‐2‐One Hybrids as Potential Anti‐Alzheimer's Disease Agents

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder for which single‐target therapies often provide insufficient benefit, motivating the development of multi‐target‐directed ligands (MTDLs). In this study, a novel series of benzimidazolone‐based hybrids incorporating piperazine, coumarin, and triazole moieties was designed,
Fatih Yılmaz, Emre Menteşe, Ozan Emre Eyüpoğlu, Bahittin Kahveci, Mustafa Emirik   +4 more
wiley   +1 more source

Economic Evidence on Biliary Tract Cancer: A Systematic Review. [PDF]

Cancers (Basel)
Rocha-Gomes J, Teixeira AS, Ruiz-Romeo M, Oliveira JM, Ramos P.   +4 more
europepmc   +1 more source

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani, Ramin Yaghobi, Mohsen Khosravi Maharlooei, Mehdi Golshan, Mohammad Hossein Karimi   +4 more
wiley   +1 more source

The Role and Mechanism of Incretins in Gynaecologic Diseases

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
This review outlines the mechanisms of incretins in polycystic ovary syndrome, endometriosis and gynaecological cancers, highlighting the translational potential of incretin‐based therapies for metabolic‐associated gynaecological disorders. ABSTRACT Background Obesity is a major global public health concern closely linked to the development and ...
Jiayu Yan, Minyue Cao, Yan Ding, Yiqin Zhang, Yihan Sun, Genyi Jiang, Yanli Zhang, Luyao Kang, Xue Zhou, Jing Luo, Bilan Li   +10 more
wiley   +1 more source