Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis [PDF]
EMBO Molecular Medicine, 2023 Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive.
Jyothi Padiadpu +13 more
doaj +2 more sources
Epiregulin, epigen and betacellulin antibodies and axial elongation in young guinea pigs with lens-induced myopization [PDF]
BMC Ophthalmology, 2022 Background To examine an effect of intravitreally applied antibodies against epidermal growth factor family members, namely epiregulin, epigen and betacellulin, on ocular axial elongation.
Li Dong +8 more
doaj +2 more sources
Docosahexaenoic and Eicosapentaenoic Acid Supplementation Could Attenuate Negative Effects of Maternal Metabolic Syndrome on Liver Lipid Metabolism and Liver Betacellulin Expression in Male and Female Rat Offspring [PDF]
MetabolitesBackground/Objectives: This study investigated the effects of maternal metabolic syndrome during pregnancy on hepatic fatty acid metabolism and betacellulin expression in rat offspring.
Tomislav Mašek +3 more
doaj +2 more sources
A review of epidermal growth factor receptor ligands in glucose homeostasis [PDF]
Frontiers in EndocrinologyThe epidermal growth factor receptor (EGFR/ErbB1) is a critical regulator of cellular proliferation and differentiation. While its role in oncology is well-characterized, its contribution to glucose homeostasis has emerged as a significant area of ...
Ka-Ying Chan +5 more
doaj +2 more sources
Counteractive Effects of Copper Nanoparticles and Betacellulin on Ovarian Cells [PDF]
NanomaterialsCopper nanoparticles (CuNPs) are known to affect many ovarian cell functions. CuNPs, prepared using a chemical reduction method, were fully characterized by different means (TEM, DLS, XRD, Z potential, XPS, and AES).
Alexander V. Sirotkin +6 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells.
Hee-Sook Jun +2 more
exaly +3 more sources
Betacellulin regulates gap junction intercellular communication by inducing the phosphorylation of connexin 43 in human granulosa-lutein cells [PDF]
Journal of Ovarian Research, 2023 Background The gap junction protein, connexin 43 (Cx43) is highly expressed in human granulosa-lutein (hGL) cells. The phosphorylation of certain amino acid residues in the Cx43 protein has been shown to be related to a decline in gap junction ...
Yuxi Li +5 more
doaj +2 more sources
EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells [PDF]
Journal of Ovarian ResearchThe epidermal growth factor (EGF)-like factors, comprising amphiregulin (AREG), betacellulin (BTC), and epiregulin (EREG), play a critical role in regulating the ovulatory process.
Yuxi Li +4 more
doaj +2 more sources
Epidermal growth factor receptor ligands enriched in follicular fluid exosomes promote oncogenesis of fallopian tube epithelial cells [PDF]
Cancer Cell InternationalBackground Incessant ovulation is the main etiologic factor of ovarian high-grade serous carcinomas (HGSC), which mostly originate from the fallopian tube epithelium (FTE).
Aye Aye Khine +5 more
doaj +2 more sources
A differentiation protocol for generating pancreatic delta cells from human pluripotent stem cells [PDF]
Frontiers in Cell and Developmental BiologyIn this protocol, we detail a seven-stage differentiation methodology for generating pancreatic delta cells (SC-delta cells) from human pluripotent stem cells (hPSCs).
Tongran Zhang +19 more
doaj +2 more sources