Results 31 to 40 of about 2,589 (150)

Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.

PLoS ONE, 2023
Transient receptor potential (TRP) channels are activated by various extracellular and intracellular stimuli and are involved in many physiological events.
Manae Tatsumi, Takayuki Kishi, Satoru Ishida, Hiroki Kawana, Akiharu Uwamizu, Yuki Ono, Kouki Kawakami, Junken Aoki, Asuka Inoue   +8 more
doaj   +1 more source

Bone marrow mesenchymal stem cells stimulate proliferation and neuronal differentiation of retinal progenitor cells. [PDF]

PLoS ONE, 2013
During retina development, retinal progenitor cell (RPC) proliferation and differentiation are regulated by complex inter- and intracellular interactions.
Jing Xia, Min Luo, Ni Ni, Junzhao Chen, Yamin Hu, Yuan Deng, Jing Ji, Jibo Zhou, Xianqun Fan, Ping Gu   +9 more
doaj   +1 more source

Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function

Membranes, 2022
Ca2+-activated Cl− channels (TMEM16, also known as anoctamins) perform important functions in cell physiology, including modulation of cell proliferation and cancer growth.
Sinje Leitzke, Jana Seidel, Björn Ahrens, Rainer Schreiber, Karl Kunzelmann, Maria Sperrhacke, Sucharit Bhakdi, Karina Reiss   +7 more
doaj   +1 more source

HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells.

PLoS ONE, 2008
BackgroundThe response rate to EGFR tyrosine kinase inhibitors (TKIs) may be poor and unpredictable in cancer patients with EGFR expression itself being an inadequate response indicator.
Anthony Kong, Véronique Calleja, Pierre Leboucher, Adrian Harris, Peter J Parker, Banafshé Larijani   +5 more
doaj   +1 more source

Interleukin 12p40 Deficiency Promotes Abdominal Aortic Aneurysm by Activating CCN2/MMP2 Pathways

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Development of abdominal aortic aneurysm (AAA) is associated with proinflammatory cytokines including interleukin‐12 (IL12). Deficiency of interleukin 12p40 (IL12p40) increases localized fibrotic events by promoting TGFβ2 (transforming growth ...
Neekun Sharma, Chetan P. Hans
doaj   +1 more source

Measurement of betacellulin levels in bovine serum, colostrum and milk

, 2001
Betacellulin, a member of the epidermal growth factor (EGF) family, was originally isolated and identified from the conditioned medium from a murine pancreatic beta-cell carcinoma cell line.
Bastian, Sue, Goddard, Chris, Dunbar, Andrew J., Owens, Phillip Clyde, Priebe, Ilka K.   +4 more
core   +1 more source

Nerve Growth Factor Neutralization Suppresses beta-Cell Proliferation Through Activin A and Betacellulin

, 2015
Objective: The aim of this study was to investigate the effects of nerve growth factor (NGF) neutralization on synthesis and secretion of activin A (Act-A) and betacellulin (BTC) from primary beta cells and the importance of these relations for beta-cell
Karatug, AYŞE, Gezginci-Oktayoglu, Selda, Bolkent, Sehnaz   +2 more
core   +2 more sources

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice [PDF]

, 2008
We employed transgenic mice overexpressing betacellulin (BTC) to study its effects in the gut. BTC stimulated crypt cell proliferation and markedly increased intestinal size, while the crypt-villus architecture was preserved.
Eckhard Wolf, Marlon R. Schneider, Dahlhoff, Maik, Wolf, Eckhard, Markus Gerhard, Horst, David, Frank T. Kolligs, Schneider, Marlon R., Gerhard, Markus, Kolligs, Frank T., David Horst, Maik Dahlhoff   +11 more
core   +1 more source

Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands. [PDF]

PLoS ONE, 2013
The epidermal growth factor receptor (EGFR) regulates normal growth and differentiation, but dysregulation of the receptor or one of the EGFR ligands is involved in the pathogenesis of many cancers.
Lasse Henriksen, Michael Vibo Grandal, Stine Louise Jeppe Knudsen, Bo van Deurs, Lene Melsæther Grøvdal   +4 more
doaj   +1 more source

Betacellulin, a member of the epidermal growth-factor family, is overexpressed in human pancreatic-cancer.

, 1995
Human pancreatic ductal adenocarcinomas overexpress the epidermal growth factor (EGF) receptor. Betacellulin is a mitogenic polypeptide that binds and activates this receptor.
Kobrin M, Yokoyama M, Ebert M, Friess H, Funatomi H, Buchler M, Korc M   +6 more
core   +1 more source