Betacellulin induces increased retinal vascular permeability in mice. [PDF]
PLoS ONE, 2010 Diabetic maculopathy, the leading cause of vision loss in patients with type 2 diabetes, is characterized by hyper-permeability of retinal blood vessels with subsequent formation of macular edema and hard exudates.
Bela Anand-Apte +6 more
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Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects [PDF]
BMC Medical Genetics, 2006 Background Betacellulin is a member of the epidermal growth factor family, expressed at the highest levels predominantly in the pancreas and thought to be involved in islet neogenesis and regeneration.
Karim Mohammad A +4 more
doaj +3 more sources
Stem Cell ResearchSeveral members of the epidermal growth factor (EGF) family have been implicated in the biology of schizophrenia (Ketharanathan et al., 2024). The EGF-related ligand, Betacellulin (BTC), plays an important role in the proliferation and differentiation of
Agustin Cota-Coronado +7 more
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Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice [PDF]
Molecular Oncology, 2020 Pancreatic ductal adenocarcinoma (PDAC) will soon belong to the top three cancer killers. The only approved specific PDAC therapy targets the epidermal growth factor receptor (EGFR).
Kathrin Hedegger +6 more
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Proteome-Guided Drug Target Discovery for Periodontitis. [PDF]
J Clin PeriodontolABSTRACT Background and Objective Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease. Materials and Methods We integrated proteomics data from deCODE genetics with periodontitis genome‐wide association studies ...
Alayash Z +8 more
europepmc +2 more sources
GLP-1、Betacellulin、Activin A、bFGF 和 Nicotinamid 联合诱导小鼠胚胎干细胞分化为胰岛素分泌细胞
Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】探讨体外联合应用GLP-1、betacellulin、activinA、bFGF和nicotinamide5种生长因子能否将小鼠胚胎干细胞(ES细胞)诱导分化为胰岛素分泌细胞。【方法】以GLP-1、betacellulin、activinA、bFGF和nicoti-namide5种生长因子诱导E14.1小鼠ES细胞30d后,应用RT-PCR、DTZ染色和免疫组化检测分化细胞胰岛素表达,以流式细胞仪检测胰岛素分泌细胞的分化率,用RIA法测定培养液中胰岛素水平。【结果 ...
doaj +1 more source
Experimental and Clinical Evidence Suggests That Treatment with Betacellulin Can Alleviate Th2-Type Cytokine-Mediated Impairment of Skin Barrier Function [PDF]
International Journal of Molecular Sciences, 2022 Yoshie Umehara +2 more
exaly +2 more sources
Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study [PDF]
Journal of Clinical and Diagnostic Research, 2015 Background: The host immune response to bacterial dental plaque determines periodontal disease susceptibility by increasing the secretion of inflammatory cytokines.
Gauri M Ugale +6 more
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BTC as a Novel Biomarker Contributing to EMT via the PI3K-AKT Pathway in OSCC
Frontiers in Genetics, 2022 Purpose: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck, while metastasis is the main cause of OSCC-related death. There is an urgent need to explore novel prognostic biomarkers and identify biological
Ting Shen +23 more
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Olfactory Ensheathing Cell Transplantation Combined With Electrical Epidural Stimulation as a Long-Term Treatment for Severe Spinal Cord Injury in Female Fischer 344 Rats. [PDF]
Eur J NeurosciThis study combined two promising therapies, olfactory ensheathing cell (OEC) transplantation and electrical epidural stimulation, to help reestablish circuit connectivity following a complete, midthoracic spinal cord transection in inbred Fischer 344 rats (A, B).
Ingraham Dixie KL +7 more
europepmc +2 more sources