Results 21 to 30 of about 2,589 (150)

Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

iScience, 2022
Summary: Oncogenic mutations in the EGFR gene account for 15–20% of lung adenocarcinoma (LUAD) cases. However, the mechanism for EGFR driven tumor development and growth is not fully understood.
Suresh Chava, Suresh Bugide, Xuchen Zhang, Romi Gupta, Narendra Wajapeyee   +4 more
doaj   +1 more source

Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells

Frontiers in Immunology, 2022
IntroductionThe Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and TGF-α, controls cellular proliferation and invasion and is overexpressed in various ...
Dehan Comez, Dehan Comez, Jacqueline Glenn, Jacqueline Glenn, Stephanie M. Anbuhl, Stephanie M. Anbuhl, Raimond Heukers, Raimond Heukers, Martine J. Smit, Stephen J. Hill, Stephen J. Hill, Laura E. Kilpatrick, Laura E. Kilpatrick   +12 more
doaj   +1 more source

Betacellulin regulates peripheral nerve regeneration by affecting Schwann cell migration and axon elongation

Molecular Medicine, 2021
Background Growth factors execute essential biological functions and affect various physiological and pathological processes, including peripheral nerve repair and regeneration.
Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang, Sheng Yi   +7 more
doaj   +1 more source

Betacellulin drives therapy resistance in glioblastoma [PDF]

, 2020
Background: The transcription factor signal transducer and activator of transcription 3 (STAT3) drives progression in glioblastoma (GBM), suggesting STAT3 as a therapeutic target. Surprisingly however, GBM cells generally show primary resistance to STAT3
Shokat, Kevan M, Luo, X., Weiss, William A, Weiss, W.A., Baldwin, Albert, Wong, R.A., Mayekar, M.K., An, Zhenyi, Haderk, F., Shokat, K.M., Baldwin, A., Bivona, T.G., Lu, Edbert D, Bivona, Trever G, Haderk, Franziska, Fan, Q., An, Z., Wong, Robyn A, Fan, Qiwen, Lu, E.D., Mayekar, Manasi K, Luo, Xujun   +21 more
core   +1 more source

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine

Neoplasia: An International Journal for Oncology Research, 2021
Patient-derived xenograft (PDX) tumor models represent a valuable platform for identifying new biomarkers and novel targets, to evaluate therapy response and resistance mechanisms.
Maria Rivera, Iduna Fichtner, Annika Wulf-Goldenberg, Christine Sers, Johannes Merk, Giannino Patone, Keziban M. Alp, Tamara Kanashova, Philipp Mertins, Jens Hoffmann, Ulrike Stein, Wolfgang Walther   +11 more
doaj   +1 more source

Actions of betacellulin in the gastrointestinal tract [PDF]

, 2009
This work employed a transgenic mouse model to investigate the functions and effects elicited by the peptide growth factor betacellulin (BTC), an EGFR ligand, on the physiology and pathology of the gastrointestinal tract.
Dahlhoff, Maik
core   +1 more source

Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid. [PDF]

PLoS ONE, 2017
While all 2-methylene-19-nor analogs of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) tested produce an increase in epidermal thickness in the rhino mouse, only a subset reduce utricle size (comedolysis).
Jamie M Ahrens, James D Jones, Nirca J Nieves, Ann M Mitzey, Hector F DeLuca, Margaret Clagett-Dame   +5 more
doaj   +1 more source

Role of activin a hormone, betacellulin (BTC) growth factor, and Heparin binding epidermal growth factor on mice embryonic development after oral administration of glycyrrhiza glabra [PDF]

, 2022
Glycyrrhiza glabra is a herbal plant used for treatment of many infertility diseases. Its roots, a common herbal source, are described to soothe fetuses in pregnant mice, but there isn't enough research to know if it's safe to take during pregnancy and ...
Al-Dujaily, Saad Salih, Fadhil, Lamyaa Abdulridha, Abbas, Amal Khudair   +2 more
core   +1 more source

Differentiation of Adult Hepatic Stem-Like Cells into Pancreatic Endocrine Cells

Cell Transplantation, 2005
To apply cell transplantation for treatment of diabetes mellitus, a sufficient number of β-cell sources are required. In the present study, we examined whether an epithelial cell line obtained from normal adult rat liver, namely hepatic stem-like (HSL ...
Satoko Yamada, Kunihiko Terada, Yasuharu Ueno, Toshihiro Sugiyama, Masaharu Seno, Itaru Kojima M.D.   +5 more
doaj   +1 more source

EGF receptor ligands: recent advances [version 1; referees: 3 approved]

F1000Research, 2016
Seven ligands bind to and activate the mammalian epidermal growth factor (EGF) receptor (EGFR/ERBB1/HER1): EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin ...
Bhuminder Singh, Graham Carpenter, Robert J. Coffey   +2 more
doaj   +1 more source