Results 51 to 60 of about 2,589 (150)

Aqueous humour concentrations of HB‐EGF, EGF and VEGF‐A and axial length in humans

Acta Ophthalmologica, Volume 103, Issue 8, Page 919-928, December 2025.
Abstract Purpose To investigate relationships between the intraocular concentrations of heparin‐binding epidermal growth factor (HB‐EGF), epidermal growth factor (EGF) and vascular endothelial growth factor A (VEGF‐A) in dependence on axial length in humans. Design Clinical interventional cohort study.
Wen‐Da Zhou, Li Dong, Yu‐Hang Yang, Yuan He, Xiao‐Zhen Wang, Han‐Qing Zhao, Rui‐Heng Zhang, Jost B. Jonas, Wen‐Bin Wei   +8 more
wiley   +1 more source

Betacellulin, a member of the EGF family, ameliorates atopic dermatitis-like symptoms via EGFR–JNK/ERK-mediated activation of autophagy

Allergology International
Background: The expression of betacellulin (BTC), which functions as a ligand for the EGF receptor (EGFR), is markedly reduced in the lesional skin of individuals with atopic dermatitis (AD), and it can improve Th2-type cytokine-mediated impairment of ...
Alafate Abudouwanli, Ge Peng, Wanchen Zhao, Quan Sun, Mengyao Yang, Yi Tan, Hideoki Ogawa, Ko Okumura, François Niyonsaba   +8 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S259-S306, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Chloe J. Peach, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Laura Kilpatrick, Doris Koesling, Michaela Kuhn, Birgit Leitinger, David MacEwan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes‐Peter Stasch, Scott A. Waldman   +31 more
wiley   +1 more source

Update on HER-2 as a target for cancer therapy: alternative strategies for targeting the epidermal growth factor system in cancer [PDF]

, 2001
The epidermal growth factor (EGF) family of ligands and receptors interact to influence cell division, differentiation and motility. Much evidence supports their importance in causing and sustaining cell transformation in model systems and in human ...
Gullick, William J.
core   +1 more source

Ventilation-induced increases in EGFR ligand mRNA are not altered by intra-amniotic LPS or ureaplasma in preterm lambs.

PLoS ONE, 2014
Chorioamnionitis and mechanical ventilation are associated with bronchopulmonary dysplasia (BPD) in preterm infants. Mechanical ventilation at birth activates both inflammatory and acute phase responses.
Noah H Hillman, Tate Gisslen, Graeme R Polglase, Suhas G Kallapur, Alan H Jobe   +4 more
doaj   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, Volume 3, Issue 3, September 2025.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

The roles of betacellulin in epithelial ovarian cancer migration and proliferation

, 2018
Epithelial ovarian cancer is the most lethal gynecological malignancy in developed countries. Although extensive studies have been done in the past decades to develop early detection methods and novel therapeutic strategies for epithelial ovarian cancer,
Zhao, Jianfang
core   +1 more source

Marked variability in bioactivity between commercially available bovine colostrum for human use; implications for clinical trials.

PLoS ONE, 2020
BackgroundColostrum, the milk produced during first few days after birth, is rich in immunoglobulins, antimicrobial peptides & growth factors. Multiple clinical trials using bovine colostrum are ongoing but with no assessment of test product bioactivity ...
Raymond J Playford, Meg Cattell, Tania Marchbank   +2 more
doaj   +1 more source

Transcriptional Changes in Cumulus Cells During In Vitro Maturation of Human Oocytes

Molecular Reproduction and Development, Volume 92, Issue 6, June 2025.
ABSTRACT This study assessed transcriptional changes in human cumulus cells (CCs) during oocyte maturation In Vitro. CCs were collected from 25 cumulus‐oocyte complexes derived from surplus ovarian medulla tissue of eight women (mean age 29 years, range 19–36) undergoing ovarian tissue cryopreservation without ovarian stimulation.
Jesús Cadenas, Cristina Subiran Adrados, Stine Gry Kristensen, Kirsten Tryde Macklon, Vinnie Hornshøj Greve, Jens Fedder, Linn Salto Mamsen, Claus Yding Andersen   +7 more
wiley   +1 more source

Identification of BTC and KLF15 in Vascular Smooth Muscle Cells as Key Biomarkers for Abdominal Aortic Aneurysm via Machine Learning and In Vitro Experiments

Cardiovascular Innovations and Applications
We aimed to identify molecular candidates to serve as diagnostic biomarkers and therapeutic targets for abdominal aortic aneurysm (AAA). We conducted integrative bioinformatics analysis and used machine learning for key genetic screening. Gene expression
Yifei Chen, Honghao Huang, Yuyan Lyu, Yuehong Wang, Jun Pu   +4 more
doaj   +1 more source