Results 71 to 80 of about 2,589 (150)

Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells

, 2007
The major obstacle in cell therapy of diabetes mellitus is the limited source of insulin-producing beta cells. Very recently, it was shown that a five-stage protocol recapitulating in vivo pancreatic organogenesis induced pancreatic beta cells in vitro ...
Park, Kyong Soo, Sung Soo Chung, Tae Hyuk Kim, Sun Kyung Oh, Lim, Jung Mee, Moon, Shin Yong, Kyong Soo Park, Park, Sang Gyu, Cho, Young Min, Oh, Sun Kyung, Young Min Choi, Kim, Jae Hyeon, Choi, Young Min, Chung, Sung Soo, Jae Hyeon Kim, Young Min Cho, Shin Yong Moon, Jung Mee Lim, Dae Hoon Yoo, Hong Kyu Lee, Kim, Tae Hyuk, Lee, Hong Kyu, Yoo, Dae Hoon, Sang Gyu Park   +23 more
core   +1 more source

Epidermal growth factor receptor inhibition potentiates chemotherapeutics‐mediated sensitization of metastatic breast cancer stem cells

Cancer Reports, Volume 7, Issue 3, March 2024.
Abstract Background Metastasis has been a cause of the poor prognosis and cancer relapse of triple‐negative breast cancer (TNBC) patients. The metastatic nature of TNBC is contributed by the breast cancer stem cells (CSCs) which have been implicated in tumorigenesis.
Trisha Kar, Prachi Dugam, Surbhi Shivhare, Swathi R. Shetty, Subholakshmi Choudhury, Debanjan Sen, Barnali Deb, Swapan Majumdar, Sudhan Debnath, Amitava Das   +9 more
wiley   +1 more source

Betacellulin regulates hair follicle development and hair cycle induction and enhances angiogenesis in wounded skin [PDF]

, 2007
Betacellulin (BTC) belongs to the EGF family, whose members play important roles in skin morphogenesis, homeostasis, and repair. However, the role of BTC in skin biology is still unknown.
Eckhard Wolf, Hasse, S, Laurence Feldmeyer, Antsiferova, Maria, Hasse, Sybille, Paus, R, Marlon R. Schneider, Maria Antsiferova, Dahlhoff, Maik, Wolf, E, Feldmeyer, L, Schneider, Marlon R., Paus, Ralf, Bugnon, Philippe, Maik Dahlhoff, Schneider, M R, Dahlhoff, M, Schneider, Marlon R, Bugnon, P, Werner, Sabine, Ralf Paus, Sybille Hasse, Wolf, Eckhard, Feldmeyer, Laurence, Antsiferova, M, Philippe Bugnon, Sabine Werner, Werner, S   +27 more
core   +1 more source

Freeze‐Dried Mesenchymal Stem Cells: From Bench to Bedside. Review

Advanced Biology, Volume 8, Issue 2, February 2024.
Freeze‐dried mesenchymal stem cells (MSCs) are able to restore damaged tissues and organs. Freeze‐dried MSCs can be stored for many years at a room temperature, even at home. They do not require special equipment, reagents and energy costs. Abstract This review describes the freeze‐dried mesenchymal stem cells (MSCs) and their ability to restore ...
Teona Paresishvili, Zurab Kakabadze
wiley   +1 more source

Betacellulin and Activin A Coordinately

, 2014
Rat pancreatic AR42J cells possess exocrine and neuroendocrine properties. Activin A induces morphological changes and converts them into neuron-like cells. In activin-treated cells, mRNA for pancreatic polypeptide (PP) but not that for either insulin or
Convert Amylase-secreting Pancreatic, Insulin-secreting Cells, Masaharu Seno, Hidenori Yamada, Itaru Kojima, Arj Cells   +5 more
core  

Foxf2 plays a dual role during transforming growth factor beta-induced epithelial to mesenchymal transition by promoting apoptosis yet enabling cell junction dissolution and migration

Breast Cancer Research, 2018
Background The most life-threatening step during malignant tumor progression is reached when cancer cells leave the primary tumor mass and seed metastasis in distant organs. To infiltrate the surrounding tissue and disseminate throughout the body, single
Nathalie Meyer-Schaller, Chantal Heck, Stefanie Tiede, Mahmut Yilmaz, Gerhard Christofori   +4 more
doaj   +1 more source

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

Mediators of Inflammation, 2018
Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive fibrosis, ultimately leading to end-stage renal disease. Although many studies have investigated the factors involved in the progressive deterioration of renal ...
Sandra Rayego-Mateos, Raul Rodrigues-Diez, Jose Luis Morgado-Pascual, Floris Valentijn, Jose M. Valdivielso, Roel Goldschmeding, Marta Ruiz-Ortega   +6 more
doaj   +1 more source

Fentanyl Overdose Causes Prolonged Cardiopulmonary Dysregulation in Male SKH1 Mice

Pharmaceuticals
Fentanyl overdose is a survivable condition that commonly resolves without chronic overt changes in phenotype. While the acute physiological effects of fentanyl overdose, such as opioid-induced respiratory depression (OIRD) and Wooden Chest Syndrome ...
Mackenzie Newman, Heather Connery, Swapna Kannan, Aarti Gautam, Rasha Hammamieh, Nabarun Chakraborty, Jonathan Boyd   +6 more
doaj   +1 more source

A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth

, 2000
Activin A (Act.A), a member of the transforming growth factor beta family of secreted proteins, has been implicated in the regulation of growth and differentiation of various cell types. Betacellulin (BTC), a member of the epidermal growth factor family,
Beattie, Gillian M., Lopez, Ana D.], Dib, Sergio Atala [UNIFESP], Demeterco, Carla [UNIFESP], Hayek, Alfredo   +4 more
core   +1 more source

Epidermal growth factor and betacellulin mediate signal transduction through co‐expressed ErbB2 and ErbB3 receptors

, 1997
Interleukin‐3 (IL‐3)‐dependent murine 32D cells do not detectably express epidermal growth factor receptors (EGFRs) and do not proliferate in response to EGF, heregulin (HRG) or other known EGF‐like ligands. Here, we report that EGF specifically binds to
Lee, Chong‐Chou, Pierce, Jacalyn H, Wang, Ling‐Mei, Tang, Careen, Bottaro, Donald, Alimandi, Maurizio, Frankel, Mark, Lippman, Marc, Kuo, Angera, Fedi, Paolo   +9 more
core   +1 more source