Results 81 to 90 of about 2,589 (150)

Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome and complex eye pathology.

, 2005
The EGF family comprises a network of ligands and receptors that regulate proper development and elicit diverse functions in physiology and pathology. Betacellulin (BTC) is a rather poorly characterized member of the EGF family whose in vivo effects have
Renner-Mueller, I., Dalke, C., Wanke, R., Dahlhoff, M., Puk, O., Graw, J., Wolf, E., Schneider, M.R., Herbach, N.   +8 more
core   +1 more source

The molecular and cellular biology of pancreatic ß cell differentiation in vitro [PDF]

, 2002
Previous studies have revealed that embryonic stem (ES) cells are capable of differentiating spontaneously towards pancreatic P cells. The use of growth factors and specific agents, such as nicotinamide, can further enhance this effect in a process known
Gammell, Patrick
core   +2 more sources

Regulation of the EGFR ligands amphiregulin and betacellulin in colorectal carcinoma cells through DNA methylation dependent mechanisms

, 2012
Kolorektale Karzinome zählen zu den häufigsten malignen Erkrankungen des Menschen. Ihre Entstehung ist das Ergebnis einer Reihe molekularer Veränderungen, die in ihrer Summe zu unkontrolliertem Zellwachstum und unkontrollierter Zellvermehrung führen ...
Kelm, Anne Sophie
core   +1 more source

Supplementary Figure S4 from Ligand-Dependent Activation of EGFR in Follicular Dendritic Cells Sarcoma is Sustained by Local Production of Cognate Ligands

, 2013
Expression of betacellulin (BTC) in pancreatic alpha ...
Piera Balzarini (14930340), Daniela Bosisio (503453), Giulio Rossi (147561), Stefano Pileri (813858), Silvano Sozzani (376589), Wilma Pellegrini (14991468), Elisa Rossi (730558), Emanuele Giurisato (826034), Fabio Facchetti (376587), Antonio Marchetti (59181), William Vermi (376579), Silvia Lonardi (489795), Daniela Medicina (157321), Claudio Doglioni (249841)   +13 more
core   +1 more source

Epidermal growth factor and betacellulin mediate signal transduction trough co-expressed ErbB-2 and ErbB-3 receptors

, 1997
Interleukin-3 (IL-3)-dependent murine 32D cells do not detectably express epidermal growth factor receptors (EGFRs) and do not proliferate in response to EGF, heregulin (HRG) or other known EGF-like ligands. Here, we report that EGF specifically binds to
Tang, C., Dp, Bottaro, Jh, Pierce, Lm, Wang, Frankel, M., Lippman, M., Chong Chou, L., Kuo, A., Fedi, P., Alimandi, M.   +9 more
core   +1 more source

Sequential and γ-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth

, 2010
Betacellulin (BTC) belongs to the family of epidermal growth factor (EGF)-like growth factors that are expressed as transmembrane precursors and undergo proteolytic ectodomain shedding to release soluble mature ligands.
Peter J. Dempsey, Li Shang, Alexander Stoeck   +2 more
core   +1 more source

Impaired Fertility in Transgenic Mice Overexpressing Betacellulin. [PDF]

, 2007
Impaired fertility in transgenic mice overexpressing Betacellulin Peptide growth factors regulate many cellular functions by autocrine, paracrine, juxtacrine or endocrine mechanisms.
Gratao, Ana Angelica
core   +1 more source

Betacellulin: defining a novel sub-type in schizophrenia

Prof Suresh SundramSchizophrenia is a severe lifelong mental disorder affecting 0.7% of the world population with only partially effective symptomatic treatments. Its cause is unknown and thus cures cannot be developed currently. A promising candidate is

core  

Non-beta-cell progenitors in pregnant mice and the origin and functionality of beta-cells after diabetic recovery in a c-Myc ablation model [PDF]

The debate regarding the contribution of adult stem/progenitor cells during normal growth and beta-cell regeneration is far from being resolved. Therefore, we addressed in two distinct situations the origin of new beta-cells.
Abouna, Sylvie
core  

Сopper nanoparticles supported on charcoal and betacellulin – Two novel stimulators of ovarian granulosa cell functions and their functional interrelationships [PDF]

The present experiments are aimed to examine the effect of copper nanoparticles supported on charcoal (CuNPs/ C), growth factor betacellulin (BTC) and their interrelationships in the control of ovarian cell functions. Porcine ovarian granulosa cells were
Martín-García, Iris, Harrath, Abdel Halim, Bartušová, Michaela, Fabova, Zuzana, Alonso, Francisco, Loncová, Barbora, Sirotkin, Alexander V.   +6 more
core   +1 more source