Results 61 to 70 of about 2,589 (150)

A Structural Insight Into Two Important ErbB Receptors (EGFR and HER2) and Their Relevance to Non‐Small Cell Lung Cancer

Archiv der Pharmazie, Volume 358, Issue 4, April 2025.
This review evaluates the structures of epidermal growth factor receptor (EGFR) family members and investigates their relation to non‐small cell lung cancer (NSCLC). The development of fourth‐generation inhibitors like EAI045 and further innovative drugs to overcome this resistance problem is a must to cure EGFR‐related NSCLC.
Edanur Topalan, Ahmet Büyükgüngör, Melih Çiğdem, Sinan Güra, Belgin Sever, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci   +8 more
wiley   +1 more source

Betacellulin-induced beta cell proliferation and regeneration is mediated by activation of ErbB-1 and ErbB-2 receptors.

PLoS ONE, 2011
BackgroundBetacellulin (BTC), a member of the epidermal growth factor family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells.
Yoon Sin Oh, Seungjin Shin, Youn-Jung Lee, Eung Hwi Kim, Hee-Sook Jun   +4 more
doaj   +1 more source

Neurobiology of COVID‐19‐Associated Psychosis/Schizophrenia: Implication of Epidermal Growth Factor Receptor Signaling

Neuropsychopharmacology Reports, Volume 45, Issue 1, March 2025.
Coronavirus directly transactivates epidermal growth factor receptors. Coronavirus stimulates epidermal growth factor release by ectodomain shedding. The brain activation of epidermal growth factor receptors results in acute or chronic psychotic behaviors.
Hiroyuki Nawa, Masaaki Murakami
wiley   +1 more source

Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alpha. [PDF]

, 2010
Cellular signaling via epidermal growth factor (EGF) and EGF-like ligands can determine cell fate and behavior. Osteoblasts, which are responsible for forming and mineralizing osteoid, express EGF receptors and alter rates of proliferation and ...
Genetos, Damian C, Rao, Rameshwar R, Vidal, Martin A   +2 more
core   +1 more source

New insights into the function and pathophysiology of the ectodomain sheddase A Disintegrin And Metalloproteinase 10 (ADAM10)

The FEBS Journal, Volume 291, Issue 13, Page 2733-2766, July 2024.
There is an increasing appreciation that the A Disintegrin And Metalloproteinase 10 (ADAM10) is of importance in health and disease. This review aims to summarize recent findings referring to the cell biology and pathophysiological implications of ADAM10.
David Rosenbaum, Paul Saftig
wiley   +1 more source

PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua

Reproductive Biology and Endocrinology, 2012
Background Viable embryos secrete preimplantation factor (PIF), a peptide that has autocrine effects where levels correlate with cultured embryos development.
Barnea Eytan R, Kirk David, Paidas Michael J   +2 more
doaj   +1 more source

miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas

Journal of Extracellular Vesicles, 2020
Exosomes, or small extracellular vesicles (sEVs), serve as intercellular messengers with key roles in normal and pathological processes. Our previous work had demonstrated that Dsg2 expression in squamous cell carcinoma (SCC) cells enhanced both sEV ...
Joseph P. Flemming, Brianna L. Hill, Mohammed W. Haque, Jessica Raad, Claudine S. Bonder, Larry A. Harshyne, Ulrich Rodeck, Adam Luginbuhl, James K. Wahl, Kenneth Y. Tsai, Peter J. Wermuth, Andrew M. Overmiller, Mỹ G. Mahoney   +12 more
doaj   +1 more source

Degradation meets development: Implications in β‐cell development and diabetes

Cell Biology International, Volume 48, Issue 6, Page 759-776, June 2024.
Abstract Pancreatic development is orchestrated by timely synthesis and degradation of stage‐specific transcription factors (TFs). The transition from one stage to another stage is dependent on the precise expression of the developmentally relevant TFs.
Akshaya Ashok, Guruprasad Kalthur, Anujith Kumar   +2 more
wiley   +1 more source

Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

eLife
Human Epidermal growth factor Receptor 4 (HER4 or ERBB4) carries out essential functions in the development and maintenance of the cardiovascular and nervous systems.
Raphael Trenker, Devan Diwanji, Tanner Bingham, Kliment A Verba, Natalia Jura   +4 more
doaj   +1 more source

HB‐EGF promotes progenitor cell proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium

The FEBS Journal, Volume 291, Issue 10, Page 2098-2133, May 2024.
Maintenance and regeneration of the zebrafish olfactory epithelium are supported by two distinct progenitor cell populations that occupy spatially discrete stem cell niches and mount distinct responses to different tissue conditions. Injured zebrafish olfactory epithelium cells release the signaling factor HB‐EGF, which stimulates olfactory sensory ...
Siran Sireci, Yigit Kocagöz, Aysu Sevval Alkiraz, Kardelen Güler, Zeynep Dokuzluoglu, Ecem Balcioglu, Sinem Meydanli, Mehmet Can Demirler, Nuray Sögünmez Erdogan, Stefan Herbert Fuss   +9 more
wiley   +1 more source