Results 141 to 150 of about 11,312 (266)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Transcriptome landscape of Mycoplasma synoviae when exposed to chicken cells. [PDF]

BMC Genomics
Si D, Bao S, Guo L, Yang F, He S, Li J.
europepmc   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Extracting Mechanistic Information from an Open Data Set for a Pharma-Relevant Suzuki-Miyaura Cross-Coupling Reaction. [PDF]

Org Process Res Dev
Franklin BA, Donaldson NWB, Firth JD, Horbaczewskyj CS, Aspell A, Tanner T, Whitwood AC, Wilson J, Hargreaves JK, Fairlamb IJS.   +9 more
europepmc   +1 more source

Operando Visualization of Cathode Water Management in Proton Exchange Membrane Water Electrolyzers Using Synchrotron X‐Ray Radiography

Advanced Science, EarlyView.
The cathode of proton exchange membrane water electrolyzers remains a poorly understood region despite its importance for hydrogen purity and operational safety. Operando synchrotron X‐ray radiography directly visualizes liquid water behavior and uncovers a transition from continuous to pulsating transport, providing new insight into multiphase ...
Wataru Yoshimune, Tetsuichiro Hayakawa, Yuta Miyase   +2 more
wiley   +1 more source

PBMC transcriptomic signatures reflect immune dynamics and disease activity in psoriatic arthritis. [PDF]

Front Immunol
Hou R, Liu Y, Xue D, Wu R, Xu K, Zhang L.   +5 more
europepmc   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer. [PDF]

Angiogenesis
Gomez-Escudero J, Maniati E, Holdsworth J, Beattie G, Hijazi M, Guelbert M, Elorbany S, Cutillas P, Wang J, Hodivala-Dilke K, D'Amico G.   +10 more
europepmc   +1 more source

Light‐Controlled Conductive Molecular Wire in an Artificial Lipid Membrane

Advanced Science, EarlyView.
A photochromic azobenzene derivative is shown to produce a unique photoelectric response when embedded in artificial lipid membranes. In its trans state, it forms conductive “molecular wires” that enhance membrane conductivity in the dark. Light‐induced cis isomerization suppresses this effect, showing that short‐chain molecules can modulate membrane ...
Ilaria Cardace, Lorenzo Dominici, Adriano Cola, Antonio Fieramosca, Vincenzo Ardizzone, Agostina Lina Capodilupo, Bruno Rizzuti, Milena De Giorgi, Dario Ballarini, Giuseppe Gigli, Daniele Sanvitto, Luisa De Marco   +11 more
wiley   +1 more source

Hysteresis in cavitation emissions during a ramped-then-deramped amplitude sonication: A theoretical and experimental investigation. [PDF]

Nonlinear Dyn
Zhang Y, Li S, Prentice P, Cammarano A.
europepmc   +1 more source