Results 131 to 140 of about 13,307 (305)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Analyzing the Influence of Bubble Velocity on Fluid Dynamics Considering Thermal and Water Height Effects via PIV

Thermo
This study experimentally investigates the dynamics of air bubble plumes in water under varying thermal and hydrodynamic conditions using a two-dimensional Particle Image Velocimetry (PIV) system.
Hassan Abdulmouti, Muhammed Elmnefi, Muhanad Hajjawi, Nawwal Ismael Ibrahim, Zakwan Skaf, Mazhar Azeem   +5 more
doaj   +1 more source

Simulation of coalescence, break up and mass transfer in bubble columns by using the Conditional Quadrature Method of Moments in OpenFOAM [PDF]

, 2013
The evaluation of the mass transfer rates and the fluid-dynamics aspects of bubble columns are strongly affected by the intrinsic poly-dispersity of the gas phase, namely the different dispersed bubbles are usually distributed over a certain range of ...
Buffo, Antonio, Daniele, L., Vanni, Marco, MARCHISIO, DANIELE, Peter Renze   +4 more
core  

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Study on the Wall Lubrication Force for Water-Air in Multi-Scale Bubble Columns and Experimental Validation

, 2016
The present study simulates gas-liquid flows in different scale pipes. Based on the Frank model, emphasis is placed on the acting distance of wall lubrication force from the wall. The acting distance is not constant; whereas, it is the function of device
Fei Dai, Maoming Gong, Gong, Maoming, Li, Zengxi, Li, Chunshan, Zengxi Li, Suojiang Zhang, Zhang, Suojiang, Chunshan Li, Dai, Fei   +9 more
core   +1 more source

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

Sticky Yet Slippery: Molecular Ordering Reconciles Bubble‐Surface Affinity With Ultralow Friction at the Nanoscale

Advanced Science, EarlyView.
By engineering the molecular order and thickness of PDMS layers, we reconcile the stickiness and slipperiness during bubble transport. AFM measurements and MD simulations further reveal how these nanoscale architectures tune hydrophobic interaction FHB and friction force f.
Shishuang Zhang, Jiajun Li, Huadong Tian, Zhoujie Wang, Chenyu Qiao, Jingyi Wang, Lei Xie, Hongbo Zeng   +7 more
wiley   +1 more source

Slug Velocity Measurement and Flow Regime Recognition Using Acoustic Emission Technology [PDF]

, 2013
Slug velocity measurement and flow regime recognition using acoustic emission technology are presented. Two non-intrusive and three intrusive methods were employed to detect the slug regime and measure its velocity using AE sensors. For the non-intrusive
Alssayh, Muammer Ali Ahmed
core  

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source