Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation [PDF]
Pharmaceutics, 2021 The reduced therapeutic efficacy of rizatriptan in migraine treatment is primarily due to low oral bioavailability and extensive first pass metabolism. The purpose of this investigation was to optimize the thin mucoadhesive buccal film of rizatriptan and
Anroop B. Nair +6 more
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Drug Delivery System Using a Buccal Film
Ma’aen Journal for Medical Sciences, 2023 The pharmaceutical industry has recently adopted a revolutionary strategy concerning the dosage form ' s composition and delivery methods, it is necessary to generate unique dosage forms in order to increase patient compliance, safety, and effectiveness.
Zainab Thabit Salih +2 more
doaj +4 more sources
Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery [PDF]
e-Polymers, 2021 Design of experiments is used to optimize ratios between deproteinized natural rubber latex, Eudragit® NM 30 D, and pectin for nicotine buccal film with dependent variables as moisture content, moisture uptake, and swelling index in simulated saliva 3 ...
Suksaeree Jirapornchai +6 more
doaj +3 more sources
Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction [PDF]
Pharmaceutics, 2022 The age-related loss of circulating estrogen that occurs during the menopausal transition manifests itself through a variety of symptoms including vasomotor (hot flushes and night sweats), genito-urinary syndrome (vaginal dryness and urinary symptoms ...
Sadikalmahdi Abdella +4 more
doaj +3 more sources
Improved Transmucosal Delivery of Glimepiride via Unidirectional Release Buccal Film Loaded With Vitamin E TPGS-Based Nanocarrier [PDF]
Dose-Response, 2020 Glimepiride (GMD) is a hypoglycemic agent that has variation in bioavailability for its unexpected absorption. Glimepiride was formulated in a buccal film loaded with a nanobased formulation to enhance its absorption via buccal mucosa.
Tahani S. Basahih +4 more
doaj +3 more sources
Green Nanotechnology in the Formulation of a Novel Solid Dispersed Multilayered Core-Sheath Raloxifene-Loaded Nanofibrous Buccal Film; In Vitro and In Vivo Characterization. [PDF]
Pharmaceutics, 2021 Green nanotechnology utilizes the principles of green chemistry to formulate eco-friendly nanocarrier systems to mitigate patients and environment hazards. Raloxifene (RLX) demonstrates poor aqueous solubility (BCS class II) and low bioavailability, only
Nageeb El-Helaly S +5 more
europepmc +4 more sources
Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case. [PDF]
Pharmaceutics, 2020 The formation of mucosal ulcers is an end result of epithelial damage, and it occurs due to some specific causes, such as trauma, aphthous stomatitis, lichen planus and lichenoid reactions, cytotoxic effects of chemotherapy and radiation, and drug ...
Alves TFR +9 more
europepmc +4 more sources
In Vitro and In Vivo Characterisation of a Mucoadhesive Buccal Film Loaded with Doxycycline Hyclate for Topical Application in Periodontitis. [PDF]
Pharmaceutics, 2023 Mucoadhesive films loaded with doxycycline hyclate (Doxy Hyc), consisting of mixtures of hydroxypropylmethyl cellulose (HPMC) E3, K4 and polyacrylic acid (Carbopol 940), were prepared by casting method, aiming to design a formulation intended for ...
Dinte E +14 more
europepmc +2 more sources
Aerosil in Solid-state Buccal Film for Improved and Sustained Delivery of Valsartan: Molecular Docking Studies [PDF]
Chemical and Biochemical Engineering Quarterly, 2023 To overcome low oral bioavailability and short biological half-life, improved and sustained buccal delivery of valsartan has been proposed. Valsartan film with colloidal silicon dioxide has been prepared using HPMC as mucoadhesive polymer matrix by ...
R. Swain +5 more
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Pharmacokinetics of Buprenorphine Buccal Film and Orally-administered Oxycodone in a Respiratory Study: An Analysis of Secondary Outcomes from a Randomized Controlled Trial. [PDF]
Pain Ther, 2022 To evaluate pharmacokinetic (PK) parameters and oxygen saturation as markers of abuse potential after administration of buprenorphine buccal film (BBF) and immediate-release (IR) oxycodone.
Webster LR, Cater J, Smith T.
europepmc +2 more sources