Results 131 to 140 of about 453,832 (299)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

On the Study for Taiwan\ue2s Counter-Cyclical Capital Buffer-using Credit-to-GNP gap coupled with Comprehensive Index

, 2014
Recalling the recently financial crisis, from the Asian financial crisis to the Eurozone crisis, the crises cause the huge volatility in global financial markets, and force many banks to be taken over or even closed down. They also make a great impact on
Kao, Wei-chieh
core  

Enhancement of Transverse Magneto-Optic Kerr effect in subwavelength all-dielectric guided mode gratings with a buffer layer

Results in Physics
We demonstrate a simple subwavelength all-dielectric photonic device with greatly enhanced transverse magneto-optical Kerr effect (TMOKE) in the transmission mode.
Junsheng Li, Youwen Liu, Xiao Li
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Assessing the effectiveness of buffer zones in logged Malaysia Borneo tropical forests using Tropical Soil Quality Index (TSQI) [PDF]

Tropical forests face increasing pressure from logging activities, necessitating sustainable management practices to balance economic demands with ecological preservation.
Karam Singh, Daljit Singh, Irie, Mami, Sundara Rajoo, Keeren, Abdu, Arifin   +3 more
core  

An efficient buffer scheme for flash-based databases

, 2011
Most embedded database systems are built on a two-level memory hierarchy, a RAM buffer on top of flash memory. Both kinds of memories have limited capacity, thus, how to efficiently utilize them is critical for embedded systems with resource restrictions.
Huangy, Zhifeng, Chenz, Lijun, Lijun Chen, Zhifeng Huang, Wangy, Jing, Weihua Gong, Jing Wang, Gongy, Weihua, Yangy, Liang Huai, Liang Huai Yang   +9 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Applicability of Basel III Countercyclical Capital Buffer Guidance to Emerging Market Economies: An Exploration

, 2015
Basel Committee on Banking Supervision (BCBS) has published its guidance for operating the countercyclical capital buffer. It has, inter alia, recommended that credit-to-GDP ratio could be the buffer guide. This paper argues that BCBS buffer guide is not
Tulasi, Gopinath
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

OPTIMIZATION OF BINDING BUFFER ION FOR COMBINATORIAL SELECTION OF SSDNA APTAMERS FOR FLAVONOIDS

Aptamers are synthetic, single stranded oligonucleotides that bind with high affinity and specificity to molecular targets. Binding buffer, is an influential component in the combinatorial selection of an aptamer for effective interaction between ...
Firas Rahi Alhachami, Jinan Tuma Sabah
core