Results 121 to 130 of about 225,576 (311)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Border buffers [PDF]

, 2013
[Extract] You couldn't have witnessed the terrible carnage at Bouba N'Djida National Park in Cameroon and not be alarmed about the future of biodiversity.
Laurance, William
core  

Biological buffers

, 2021
Delo opisuje, kaj so biološki pufri, kakšne lastnosti imajo, njihovo kemijsko sestavo, kako jih lahko pridobimo ter za katere pogoje so najprimernejši. Opisano je tudi, kako pufri in pH vplivajo na lastnosti proteinov ter kako vplivajo na rastlinske in ...
Tavčer, Zala
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Optimising Extraction of Specific Food Allergens from Challenging Food Matrices for Immunoassay Quantification

Foods
Simultaneous extraction of multiple clinically relevant, specific allergens from complex, processed foods for immunoassay quantification remains challenging. Moreover, shared extraction buffers remain elusive, which limits the effectiveness of multiplex (
Max D. Bermingham, Rhys T. Meredith, Hayley Mills, Sarah Maddocks, Martin D. Chapman, James A. Blaxland, Maria A. Oliver   +6 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Fiscal Buffers, Private Debt, and Stagnation: The Good, the Bad, and the Ugly [PDF]

, 2016
We revisit the empirical relationship between private/public debt and output, and build a model that reproduces it. In the model, the government provides financial assistance to credit-constrained agents to mitigate deleveraging.
VILLA, STEFANIA, Batini, Nicoletta, Melina, Giovanni   +2 more
core  

Stiffness characteristics of railway buffers: Requirements, testing and proposal of a new computational model

Applied and Computational Mechanics
In European railways, the use of UIC draw gear and side buffers to connect individual railway vehicles within a train is still established. The buffers ensure the transmission of longitudinal compressive forces between the adjacent vehicles; longitudinal
Michálek T., Liberová S., Vágner J., Jaroš P., Šlapák J.   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Behavioral Models of Input/Output Buffers Including Core Noise Coupling [PDF]

, 2008
Stievano, Igor Simone, F.G. Canavero, C. Siviero, Siviero, Claudio, I.A. Maio, Maio, Ivano Adolfo, Canavero, Flavio, I.S. Stievano   +7 more
core   +1 more source