Results 121 to 130 of about 251,253 (308)
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Effect of Riparian Buffers on Soil Redox Potentials
, 2002 Excess pollution in Eastern North Carolina has led to unprecedented regulations to reduce the nitrogen loading to the Neuse River by thirty-percent by the year 2003. The primary culprit of excess nutrients is nonpoint sources.
Ricks, Staci
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Conservation Buffers: Design Guidelines for Buffers, Corridors, and Greenways (Korean Version)
, 2008 Conservation Buffers: Design Guidelines for Buffers, Corridors, and Greenways (Korean version) Over 80 illustrated design guidelines for conservation buffers are synthesized and developed from a review of over 1,400 research publications.
Bentrup, Gary
core
Applying new regulatory criteria to protect riparian buffer zones
, 2003 Proceedings of the 2003 Georgia Water Resources Conference, held April 23-24, 2003, at the University of Georgia.The Riparian Buffer Protection Program is one of the Upper Chattahoochee Riverkeeper’s primary initiatives for protecting water quality and
Champagne, Alice J. M., Boden, Darcie
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source